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Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient




TekijätLotila Johanna, Hyvärinen Tarja, Skottman Heli, Airas Laura, Narkilahti Susanna, Hagman Sanna

KustantajaElsevier B.V.

Julkaisuvuosi2022

JournalStem Cell Research

Tietokannassa oleva lehden nimiStem Cell Research

Vuosikerta63

DOIhttps://doi.org/10.1016/j.scr.2022.102865

Verkko-osoitehttps://doi.org/10.1016/j.scr.2022.102865

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/176045232


Tiivistelmä

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system where the main pathogenetic events include demyelination and axonal degeneration. Here, we generated a human induced pluripotent stem cell (hiPSC) line from peripheral blood mononuclear cells of an MS patient utilizing Sendai virus reprogramming. The produced hiPSC line expressed pluripotency markers, differentiated into three germ layers, showed a normal karyotype and was free of virus vectors, transgenes and mycoplasma. Established hiPSCs are a valuable source for studies of MS disease modeling and drug discovery.


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Last updated on 2024-26-11 at 13:02