Mikko Metsä-Ketelä

- Professor,
Biochemistry (Department of Life Technologies)

mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku

ABE

Natural products; Streptomyces; biosynthesis

http://abelab.utu.fi

Molecular Biology

Structural Biology

3 of 9

Single cell mutant selection for metabolic engineering of actinomycetes (2022)
- Metabolic Engineering
Akhgari Amir., Baral Bikash, Koroleva Arina, Siitonen Vilja, Fewer David P., Melançon Charles E., Rahkila Jani, Metsä-Ketelä Mikko
The role of the maleimide ring system on the structure-activity relationship of showdomycin (2022)
- European Journal of Medicinal Chemistry
Rosenqvist Petja, Mäkinen Janne J, Palmu Kaisa, Jokinen Johanna, Prajapati Ranjit K, Korhonen Heidi J, Virta Pasi, Belogurov Georgiy A, Metsä-Ketelä Mikko
Biosynthesis of Diverse Type II Polyketide Core Structures in Streptomyces coelicolor M1152 (2021)
- ACS Synthetic Biology
Zhu Xuechen, Siitonen Vilja, Melancon III Charles E, Metsä-Ketelä Mikko
Deciphering the Origin and Formation of Aminopyrrole Moiety in Kosinostatin Biosynthesis (2021)
- Chinese Journal of Chemistry
Hu Yu, Zhou Qiang, Zhang Zhuan, Pan Hai-Xue, Ilina Yulia, Metsä-Ketelä Mikko, Igarashi Yasuhiro, Tang Gong-Li
Differential regulation of undecylprodigiosin biosynthesis in the yeast-scavenging Streptomyces strain MBK6 (2021)
- FEMS Microbiology Letters
Baral Bikash, Siitonen Vilja, Laughlin Mitchell, Yamada Keith, Ilomäki Mikael, Metsä-Ketelä Mikko, Niemi Jarmo
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products (2021)
- ACS Chemical Biology
Ahmed Muhammad N., Wahlsten Matti, Jokela Jouni, Nees Matthias, Stenman Ulf-Håkan, Alvarenga Danillo O., Strandin Tomas, Sivonen Kaarina, Poso Antti, Permi Perttu, Metsä-Ketelä Mikko, Koistinen Hannu, Fewer David P.
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases (2021)
- Nature Communications
Mäkinen Janne J, Shin Yeonoh, Vieras Eeva, Virta Pasi, Metsä-Ketelä Mikko, Murakami Katsuhiko S, Belogurov Georgiy A
Evolution‐Guided Engineering of Non‐Heme Iron Enzymes Involved in Nogalamycin Biosynthesis (2020)
- FEBS Journal
Benjamin Nji Wandi, Vilja Siitonen, Pedro Dinis, Vladimir Vukic, Tiina A. Salminen, Mikko Metsä‐Ketelä
Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway (2020)
- ACS Chemical Biology
Xiansha Xiao, Somayah Elsayed, Changsheng Wu, Helga van der Heul, Mikko Metsä-Ketelä, Chao Du, Andrea Prota, Chun-Chi Chen, Weidong Liu, Rey-Ting Guo, Jan Pieter Abrahams, Gilles P. van Wezel
Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3 (2020)
- Frontiers in microbiology
Soheila Matroodi, Vilja Siitonen, Bikash Baral, Keith Yamada, Amir Akhgari, Mikko Metsä-Ketelä