Mikko Metsä-Ketelä
 


mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku


ABE

Areas of expertise
Natural products; Streptomyces; biosynthesis

Research

http://abelab.utu.fi



Teaching

Molecular Biology

Structural Biology



Publications
  
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  • MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration  (2025)  
    • Nucleic Acids Research
     Zdouc, Mitja M.; Blin, Kai; Louwen, Nico L.L.; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D.; Bailey, Constance B.; Barra, Lena; Booth, Thomas J.; Bozhüyük, Kenan A.J.; Cediel-Becerra, José D.D.; Charlop-Powers, Zachary; Chevrette, Marc G.; Chooi, Yit Heng; D’Agostino, Paul M.; de Rond, Tristan; Del Pup, Elena; Duncan, Katherine R.; Gu, Wenjia; Hanif, Novriyandi; Helfrich, Eric J.N.; Jenner, Matthew; Katsuyama, Yohei; Korenskaia, Aleksandra; Krug, Daniel; Libis, Vincent; Lund, George A.; Mantri, Shrikant; Morgan, Kalindi D.; Owen, Charlotte; Phan, Chin-Soon; Philmus, Benjamin; Reitz, Zachary L.; Robinson, Serina L.; Singh, Kumar Saurabh; Teufel, Robin; Tong, Yaojun; Tugizimana, Fidele; Ulanova, Dana; Winter, Jaclyn M.; Aguilar, César; Akiyama, Daniel Y.; Al-Salihi, Suhad A.A.; Alanjary, Mohammad; Alberti, Fabrizio; Aleti, Gajender; Alharthi, Shumukh A.; Rojo, Mariela Y. Arias; Arishi, Amr A.; Augustijn, Hannah E.; Avalon, Nicole E.; Avelar-Rivas, J. Abraham; Axt, Kyle K.; Barbieri, Hellen B.; Barbosa, Julio Cesar J.; Barboza Segato, Lucas Gabriel; Barrett, Susanna E.; Baunach, Martin; Beemelmanns, Christine; Beqaj, Dardan; Berger, Tim; Bernaldo-Agüero, Jordan; Bettenbühl, Sandra M.; Bielinski, Vincent A.; Biermann, Friederike; Borges, Ricardo M.; Borriss, Rainer; Breitenbach, Milena; Bretscher, Kevin M.; Brigham, Michael W.; Buedenbender, Larissa; Bulcock, Brodie W.; Cano-Prieto, Carolina; Capela, João; Carrion, Victor J.; Carter, Riley S.; Castelo-Branco, Raquel; Castro-Falcón, Gabriel; Chagas, Fernanda O.; Charria-Girón, Esteban; Chaudhri, Ayesha Ahmed; Chaudhry, Vasvi; Choi, Hyukjae; Choi, Yukyung; Choupannejad, Roya; Chromy, Jakub; Donahey, Melinda S. Chue; Collemare, Jérôme; Connolly, Jack A.; Creamer, Kaitlin E.; Crüsemann, Max; Cruz, Andres Arredondo; Cumsille, Andres; Dallery, Jean-Felix; Damas-Ramos, Luis Caleb; Damiani, Tito; de Kruijff, Martinus; Martín, Belén Delgado; Sala, Gerardo Della; Dillen, Jelle; Doering, Drew T.; Dommaraju, Shravan R.; Durusu, Suhan; Egbert, Susan; Ellerhorst, Mark; Faussurier, Baptiste; Fetter, Artem; Feuermann, Marc; Fewer, David P.; Foldi, Jonathan; Frediansyah, Andri; Garza, Erin A.; Gavriilidou, Athina; Gentile, Andrea; Gerke, Jennifer; Gerstmans, Hans; Gomez-Escribano, Juan Pablo; González-Salazar, Luz A.; Grayson, Natalie E.; Greco, Claudio; Gomez, Juan E. Gris; Guerra, Sebastian; Flores, Shaday Guerrero; Gurevich, Alexey; Gutiérrez-García, Karina; Hart, Lauren; Haslinger, Kristina; He, Beibei; Hebra, Teo; Hemmann, Jethro L.; Hindra, Hindra; Höing, Lars; Holland, Darren C.; Holme, Jonathan E.; Horch, Therese; Hrab, Pavlo; Hu, Jie; Huynh, Thanh-Hau; Hwang, Ji-Yeon; Iacovelli, Riccardo; Iftime, Dumitrita; Iorio, Marianna; Jayachandran, Sidharth; Jeong, Eunah; Jing, Jiayi; Jung, Jung J.; Kakumu, Yuya; Kalkreuter, Edward; Kang, Kyo Bin; Kang, Sangwook; Kim, Wonyong; Kim, Geum Jin; Kim, Hyunwoo; Kim, Hyun Uk; Klapper, Martin; Koetsier, Robert A.; Kollten, Cassandra; Kovács, Ákos T.; Kriukova, Yelyzaveta; Kubach, Noel; Kunjapur, Aditya M.; Kushnareva, Aleksandra K.; Kust, Andreja; Lamber, Jessica; Larralde, Martin; Larsen, Niels J.; Launay, Adrien P.; Le, Ngoc-Thao-Hien; Lebeer, Sarah; Lee, Byung Tae; Lee, Kyungha; Lev, Katherine L.; Li, Shu-Ming; Li, Yong-Xin; Licona-Cassani, Cuauhtémoc; Lien, Annette; Liu, Jing; Lopez, Julius Adam V.; Machushynets, Nataliia V.; Macias, Marla I.; Mahmud, Taifo; Maleckis, Matiss; Martinez-Martinez, Añadir Maharai; Mast, Yvonne; Maximo, Marina F.; McBride, Christina M.; McLellan, Rose M.; Bhatt, Khyati Mehta; Melkonian, Chrats; Merrild, Aske; Metsä-Ketelä, Mikko; Mitchell, Douglas A.; Müller, Alison V.; Nguyen, Giang-Son; Nguyen, Hera T.; Niedermeyer, Timo H.J.; O’Hare, Julia H.; Ossowicki, Adam; Ostash, Bohdan O.; Otani, Hiroshi; Padva, Leo; Paliyal, Sunaina; Pan, Xinya; Panghal, Mohit; Parade, Dana S.; Park, Jiyoon; Parra, Jonathan; Rubio, Marcos Pedraza; Pham, Huong T.; Pidot, Sacha J.; Piel, Jörn; Pourmohsenin, Bita; Rakhmanov, Malik; Ramesh, Sangeetha; Rasmussen, Michelle H.; Rego, Adriana; Reher, Raphael; Rice, Andrew J.; Rigolet, Augustin; Romero-Otero, Adriana; Rosas-Becerra, Luis Rodrigo; Rosiles, Pablo Y.; Rutz, Adriano; Ryu, Byeol; Sahadeo, Libby-Ann; Saldanha, Murrel; Salvi, Luca; Sánchez-Carvajal, Eduardo; Santos-Medellin, Christian; Sbaraini, Nicolau; Schoellhorn, Sydney M.; Schumm, Clemens; Sehnal, Ludek; Selem, Nelly; Shah, Anjali D.; Shishido, Tania K.; Sieber, Simon; Silviani, Velina; Singh, Garima; Singh, Hemant; Sokolova, Nika; Sonnenschein, Eva C.; Sosio, Margherita; Sowa, Sven T.; Steffen, Karin; Stegmann, Evi; Streiff, Alena B.; Strüder, Alena; Surup, Frank; Svenningsen, Tiziana; Sweeney, Douglas; Szenei, Judit; Tagirdzhanov, Azat; Tan, Bin; Tarnowski, Matthew J.; Terlouw, Barbara R.; Rey, Thomas; Thome, Nicola U.; Torres Ortega, Laura Rosina; Tørring, Thomas; Trindade, Marla; Truman, Andrew W.; Tvilum, Marie; Udwary, Daniel W.; Ulbricht, Christoph; Vader, Lisa; van Wezel, Gilles P.; Walmsley, Max; Warnasinghe, Randika; Weddeling, Heiner G.; Weir, Angus N.M.; Williams, Katherine; Williams, Sam E.; Witte, Thomas E.; Rocca, Steffaney M. Wood; Yamada, Keith; Yang, Dong; Yang, Dongsoo; Yu, Jingwei; Zhou, Zhenyi; Ziemert, Nadine; Zimmer, Lukas; Zimmermann, Alina; Zimmermann, Christian; van der Hooft, Justin J.J.; Linington, Roger G.; Weber, Tilmann; Medema, Marnix H.
    (    A1 Refereed original research article in a scientific journal)


  • ActVI-ORFA directs metabolic flux towards actinorhodin by preventing intermediate degradation  (2024)  
    • PLoS ONE
     Zhu, Xuechen; Wang, Rongbin; Siitonen, Vilja; Vuksanovic, Nemanja; Silvaggi, Nicholas R.; Melançon III, Charles E.; Metsä-Ketelä, Mikko
    (    A1 Refereed original research article in a scientific journal)


  • Divergence of Classical and C-Ring-Cleaved Angucyclines : Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis  (2024)  
    • ACS Chemical Biology
     Nuutila Aleksi, Xiao Xiansha, van der Heul Helga U., van Wezel Gilles P., Dinis Pedro, Elsayed Somayah S., Metsä-Ketelä Mikko
    (    A1 Refereed original research article in a scientific journal)


  • Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones  (2024)  
    • ACS Synthetic Biology
     Wang Rongbin, Nji Wandi Benjamin, Schwartz Nora, Hecht Jacob, Ponomareva Larissa, Paige Kendall, West Alexis, Desanti Kathryn, Nguyen Jennifer, Niemi Jarmo, Thorson Jon S., Shaaban Khaled A., Metsä-Ketelä Mikko, Nybo S. Eric
    (    A1 Refereed original research article in a scientific journal)


  • Mechanism of Two-Component Mono-Oxygenases Involved in Anthracycline 1-Hydroxylation  (2024)  
    • ACS Catalysis
     Wandi, Benjamin Nji; Dinis, Pedro; Siitonen, Vilja; Schneider, Gunter; Schnell, Robert; Metsä-Ketelä, Mikko
    (    A1 Refereed original research article in a scientific journal)


  • Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines  (2024)  
    • Frontiers in Bioengineering and Biotechnology
     Hulst Mandy B., Zhang Le, van der Heul Helga U., Du Chao, Elsayed Somayah S., Koroleva Arina, Grocholski Thadee, Wander Dennis P. A., Metsa-Ketela Mikko, Neefjes Jacques J. C., van Wezel Gilles P.
    (    A1 Refereed original research article in a scientific journal)


  • Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates  (2024)  
    • Journal of Biological Chemistry
     Mäkinen, Janne J.; Rosenqvist, Petja; Virta, Pasi; Metsä-Ketelä, Mikko; Belogurov, Georgiy A.
    (    A1 Refereed original research article in a scientific journal)


  • Bakteerien avulla antibiootteja mikrobi- ja syöpälääkkeiksi  (2023)  
    • Duodecim
     Metsä-Ketelä Mikko, Siitonen Vilja, Artukka Erika
    (    A2 Refereed review article in a scientific journal )


  • Co-factor independent oxidases ncnN and actVA-3 are involved in the dimerization of benzoisochromanequinone antibiotics in naphthocyclinone and actinorhodin biosynthesis  (2023)  
    • FEMS Microbiology Letters
     Baral Bikash, Matroodi Soheila, Siitonen Vilja, Thapa Keshav, Akhgari Amir, Yamada Keith, Nuutila Aleksi, Metsä-Ketelä Mikko
    (    A1 Refereed original research article in a scientific journal)


  • Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins  (2023)  
    • ACS Omega
     Tirkkonen Heli, Brown Katelyn V, Niemczura Magdalena, Faudemer Zélie, Brown Cortney, Ponomareva Larissa V , Helmy Yorsta A, Thorson Jon S, Nybo S Eric, Metsä-Ketelä Mikko, Shaaban Khaled A
    (    A1 Refereed original research article in a scientific journal)


  • Evolution-inspired engineering of anthracycline methyltransferases  (2023)  
    • PNAS nexus
     Dinis Pedro, Tirkkonen Heli, Nji Wandi Benjamin N, Siitonen Vilja, Niemi Jarmo, Grocholski Thadée, Metsä-Ketelä Mikko
    (    A1 Refereed original research article in a scientific journal)


  • Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway  (2023)  
    • ACS Chemical Biology
     Artukka Erika, Schnell Robert, Palmu Kaisa, Rosenqvist Petja, Szodorai Edit, Niemi Jarmo, Virta Pasi, Schneider Gunter, Metsä-Ketelä Mikko
    (    A1 Refereed original research article in a scientific journal)


  • Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis  (2023)  
    • Communications chemistry
     Elsayed Somayah S., van der Heul Helga U., Xiao Xiansha, Nuutila Aleksi, Baars Laura R., Wu Changsheng, Metsä-Ketelä Mikko, van Wezel Gilles P.
    (    A1 Refereed original research article in a scientific journal)


  • A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor  (2022)  
    • ACS Synthetic Biology
     Wang Rongbin, Nguyen Jennifer, Hecht Jacob, Schwartz Nora, Brown Katelyn V, Ponomareva Larissa V, Niemczura Magdalena, van Dissel Dino, van Wezel Gilles P, Thorson Jon S, Metsä-Ketelä Mikko, Shaaban Khaled A, Nybo S Eric
    (    A1 Refereed original research article in a scientific journal)


  • Anthracyclines: biosynthesis, engineering and clinical applications  (2022)  
    • Natural Product Reports
     Hulst Mandy B., Grocholski Thadee, Neefjes Jacques J.C., van Wezel Gilles P., Metsä-Ketelä Mikko
    (    A2 Refereed review article in a scientific journal )


  • Fluorogenic RNA aptamers to probe transcription initiation and co-transcriptional RNA folding by multi-subunit RNA polymerases  (2022)  Methods in Enzymology Huang Yong-Heng, Trapp Vilma, Puro Oskari, Mäkinen Janne J., Metsä-Ketelä Mikko, Wahl Markus C., Belogurov Georgiy A.
    (    A3 Refereed book chapter or chapter in a compilation book)


  • Single cell mutant selection for metabolic engineering of actinomycetes  (2022)  
    • Metabolic Engineering
     Akhgari Amir., Baral Bikash, Koroleva Arina, Siitonen Vilja, Fewer David P., Melançon Charles E., Rahkila Jani, Metsä-Ketelä Mikko
    (    A1 Refereed original research article in a scientific journal)


  • The role of the maleimide ring system on the structure-activity relationship of showdomycin  (2022)  
    • European Journal of Medicinal Chemistry
     Rosenqvist Petja, Mäkinen Janne J, Palmu Kaisa, Jokinen Johanna, Prajapati Ranjit K, Korhonen Heidi J, Virta Pasi, Belogurov Georgiy A, Metsä-Ketelä Mikko
    (    A1 Refereed original research article in a scientific journal)


  • Biosynthesis of Diverse Type II Polyketide Core Structures in Streptomyces coelicolor M1152  (2021)  
    • ACS Synthetic Biology
     Zhu Xuechen, Siitonen Vilja, Melancon III Charles E, Metsä-Ketelä Mikko
    (    A1 Refereed original research article in a scientific journal)


  • Deciphering the Origin and Formation of Aminopyrrole Moiety in Kosinostatin Biosynthesis  (2021)  
    • Chinese Journal of Chemistry
     Hu Yu, Zhou Qiang, Zhang Zhuan, Pan Hai-Xue, Ilina Yulia, Metsä-Ketelä Mikko, Igarashi Yasuhiro, Tang Gong-Li
    (    A1 Refereed original research article in a scientific journal)



Last updated on 2023-12-07 at 12:21