Mikko Metsä-Ketelä
 


mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku


ABE

Natural products; Streptomyces; biosynthesis

http://abelab.utu.fi



Molecular Biology

Structural Biology



  
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  • Functional Plasticity of Methyltransferases in Anthracycline Biosynthesis: A Single Residue Reversal between Decarboxylation and Hydroxylation  (2026)  
    • ACS Catalysis
     Sang, Moli; Yang, Qingyu; Guo, Jiawei; Feng, Peiyuan; Gao, Yu; Ma, Wencheng; Li, Shengying; Metsä-Ketelä, Mikko; Zhang, Wei


  • Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA  (2026)  
    • Nature Communications
     Koroleva, Arina; Artukka, Erika; Yamada, Keith; Newmister, Sean A.; Harte, Ralph J.; Boesger, Hannah; Londen, Mikael; Sanders, Jacob N.; Tirkkonen, Heli; Kannisto, Matti; Kuin, Rosan C. M.; Hulst, Mandy; Wang, Rongbin; Leskinen, Ester; Barillec, Morgane; Niemi, Jarmo; van Wezel, Gilles P.; Neefjes, Jacques; Nybo, S. Eric; Houk, Kendall N.; Sherman, David H.; Kim, Robbert Q.; Metsä-Ketelä, Mikko


  • MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration  (2025)  
    • Nucleic Acids Research
     Zdouc, Mitja M.; Blin, Kai; Louwen, Nico L.L.; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D.; Bailey, Constance B.; Barra, Lena; Booth, Thomas J.; Bozhüyük, Kenan A.J.; Cediel-Becerra, José D.D.; Charlop-Powers, Zachary; Chevrette, Marc G.; Chooi, Yit Heng; D’Agostino, Paul M.; de Rond, Tristan; Del Pup, Elena; Duncan, Katherine R.; Gu, Wenjia; Hanif, Novriyandi; Helfrich, Eric J.N.; Jenner, Matthew; Katsuyama, Yohei; Korenskaia, Aleksandra; Krug, Daniel; Libis, Vincent; Lund, George A.; Mantri, Shrikant; Morgan, Kalindi D.; Owen, Charlotte; Phan, Chin-Soon; Philmus, Benjamin; Reitz, Zachary L.; Robinson, Serina L.; Singh, Kumar Saurabh; Teufel, Robin; Tong, Yaojun; Tugizimana, Fidele; Ulanova, Dana; Winter, Jaclyn M.; Aguilar, César; Akiyama, Daniel Y.; Al-Salihi, Suhad A.A.; Alanjary, Mohammad; Alberti, Fabrizio; Aleti, Gajender; Alharthi, Shumukh A.; Rojo, Mariela Y. Arias; Arishi, Amr A.; Augustijn, Hannah E.; Avalon, Nicole E.; Avelar-Rivas, J. Abraham; Axt, Kyle K.; Barbieri, Hellen B.; Barbosa, Julio Cesar J.; Barboza Segato, Lucas Gabriel; Barrett, Susanna E.; Baunach, Martin; Beemelmanns, Christine; Beqaj, Dardan; Berger, Tim; Bernaldo-Agüero, Jordan; Bettenbühl, Sandra M.; Bielinski, Vincent A.; Biermann, Friederike; Borges, Ricardo M.; Borriss, Rainer; Breitenbach, Milena; Bretscher, Kevin M.; Brigham, Michael W.; Buedenbender, Larissa; Bulcock, Brodie W.; Cano-Prieto, Carolina; Capela, João; Carrion, Victor J.; Carter, Riley S.; Castelo-Branco, Raquel; Castro-Falcón, Gabriel; Chagas, Fernanda O.; Charria-Girón, Esteban; Chaudhri, Ayesha Ahmed; Chaudhry, Vasvi; Choi, Hyukjae; Choi, Yukyung; Choupannejad, Roya; Chromy, Jakub; Donahey, Melinda S. Chue; Collemare, Jérôme; Connolly, Jack A.; Creamer, Kaitlin E.; Crüsemann, Max; Cruz, Andres Arredondo; Cumsille, Andres; Dallery, Jean-Felix; Damas-Ramos, Luis Caleb; Damiani, Tito; de Kruijff, Martinus; Martín, Belén Delgado; Sala, Gerardo Della; Dillen, Jelle; Doering, Drew T.; Dommaraju, Shravan R.; Durusu, Suhan; Egbert, Susan; Ellerhorst, Mark; Faussurier, Baptiste; Fetter, Artem; Feuermann, Marc; Fewer, David P.; Foldi, Jonathan; Frediansyah, Andri; Garza, Erin A.; Gavriilidou, Athina; Gentile, Andrea; Gerke, Jennifer; Gerstmans, Hans; Gomez-Escribano, Juan Pablo; González-Salazar, Luz A.; Grayson, Natalie E.; Greco, Claudio; Gomez, Juan E. Gris; Guerra, Sebastian; Flores, Shaday Guerrero; Gurevich, Alexey; Gutiérrez-García, Karina; Hart, Lauren; Haslinger, Kristina; He, Beibei; Hebra, Teo; Hemmann, Jethro L.; Hindra, Hindra; Höing, Lars; Holland, Darren C.; Holme, Jonathan E.; Horch, Therese; Hrab, Pavlo; Hu, Jie; Huynh, Thanh-Hau; Hwang, Ji-Yeon; Iacovelli, Riccardo; Iftime, Dumitrita; Iorio, Marianna; Jayachandran, Sidharth; Jeong, Eunah; Jing, Jiayi; Jung, Jung J.; Kakumu, Yuya; Kalkreuter, Edward; Kang, Kyo Bin; Kang, Sangwook; Kim, Wonyong; Kim, Geum Jin; Kim, Hyunwoo; Kim, Hyun Uk; Klapper, Martin; Koetsier, Robert A.; Kollten, Cassandra; Kovács, Ákos T.; Kriukova, Yelyzaveta; Kubach, Noel; Kunjapur, Aditya M.; Kushnareva, Aleksandra K.; Kust, Andreja; Lamber, Jessica; Larralde, Martin; Larsen, Niels J.; Launay, Adrien P.; Le, Ngoc-Thao-Hien; Lebeer, Sarah; Lee, Byung Tae; Lee, Kyungha; Lev, Katherine L.; Li, Shu-Ming; Li, Yong-Xin; Licona-Cassani, Cuauhtémoc; Lien, Annette; Liu, Jing; Lopez, Julius Adam V.; Machushynets, Nataliia V.; Macias, Marla I.; Mahmud, Taifo; Maleckis, Matiss; Martinez-Martinez, Añadir Maharai; Mast, Yvonne; Maximo, Marina F.; McBride, Christina M.; McLellan, Rose M.; Bhatt, Khyati Mehta; Melkonian, Chrats; Merrild, Aske; Metsä-Ketelä, Mikko; Mitchell, Douglas A.; Müller, Alison V.; Nguyen, Giang-Son; Nguyen, Hera T.; Niedermeyer, Timo H.J.; O’Hare, Julia H.; Ossowicki, Adam; Ostash, Bohdan O.; Otani, Hiroshi; Padva, Leo; Paliyal, Sunaina; Pan, Xinya; Panghal, Mohit; Parade, Dana S.; Park, Jiyoon; Parra, Jonathan; Rubio, Marcos Pedraza; Pham, Huong T.; Pidot, Sacha J.; Piel, Jörn; Pourmohsenin, Bita; Rakhmanov, Malik; Ramesh, Sangeetha; Rasmussen, Michelle H.; Rego, Adriana; Reher, Raphael; Rice, Andrew J.; Rigolet, Augustin; Romero-Otero, Adriana; Rosas-Becerra, Luis Rodrigo; Rosiles, Pablo Y.; Rutz, Adriano; Ryu, Byeol; Sahadeo, Libby-Ann; Saldanha, Murrel; Salvi, Luca; Sánchez-Carvajal, Eduardo; Santos-Medellin, Christian; Sbaraini, Nicolau; Schoellhorn, Sydney M.; Schumm, Clemens; Sehnal, Ludek; Selem, Nelly; Shah, Anjali D.; Shishido, Tania K.; Sieber, Simon; Silviani, Velina; Singh, Garima; Singh, Hemant; Sokolova, Nika; Sonnenschein, Eva C.; Sosio, Margherita; Sowa, Sven T.; Steffen, Karin; Stegmann, Evi; Streiff, Alena B.; Strüder, Alena; Surup, Frank; Svenningsen, Tiziana; Sweeney, Douglas; Szenei, Judit; Tagirdzhanov, Azat; Tan, Bin; Tarnowski, Matthew J.; Terlouw, Barbara R.; Rey, Thomas; Thome, Nicola U.; Torres Ortega, Laura Rosina; Tørring, Thomas; Trindade, Marla; Truman, Andrew W.; Tvilum, Marie; Udwary, Daniel W.; Ulbricht, Christoph; Vader, Lisa; van Wezel, Gilles P.; Walmsley, Max; Warnasinghe, Randika; Weddeling, Heiner G.; Weir, Angus N.M.; Williams, Katherine; Williams, Sam E.; Witte, Thomas E.; Rocca, Steffaney M. Wood; Yamada, Keith; Yang, Dong; Yang, Dongsoo; Yu, Jingwei; Zhou, Zhenyi; Ziemert, Nadine; Zimmer, Lukas; Zimmermann, Alina; Zimmermann, Christian; van der Hooft, Justin J.J.; Linington, Roger G.; Weber, Tilmann; Medema, Marnix H.


  • Three-Enzyme Cascade Catalyzes Conversion of Auramycinone to Resomycin in Chartreusin Biosynthesis  (2025)  
    • ACS Chemical Biology
     Niemczura, Magdalena; Nuutila, Aleksi; Wang, Rongbin; Rauhanen, Katariina; Nybo, S. Eric; Metsä-Ketelä, Mikko


  • ActVI-ORFA directs metabolic flux towards actinorhodin by preventing intermediate degradation  (2024)  
    • PLoS ONE
     Zhu, Xuechen; Wang, Rongbin; Siitonen, Vilja; Vuksanovic, Nemanja; Silvaggi, Nicholas R.; Melançon III, Charles E.; Metsä-Ketelä, Mikko


  • Divergence of Classical and C-Ring-Cleaved Angucyclines : Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis  (2024)  
    • ACS Chemical Biology
     Nuutila, Aleksi; Xiao, Xiansha; van der Heul, Helga U.; van Wezel, Gilles P.; Dinis, Pedro; Elsayed, Somayah S.; Metsä-Ketelä, Mikko


  • Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones  (2024)  
    • ACS Synthetic Biology
     Wang, Rongbin; Nji Wandi, Benjamin; Schwartz, Nora; Hecht, Jacob; Ponomareva, Larissa; Paige, Kendall; West, Alexis; Desanti, Kathryn; Nguyen, Jennifer; Niemi, Jarmo; Thorson, Jon S.; Shaaban, Khaled A.; Metsä-Ketelä, Mikko; Nybo, S. Eric


  • Mechanism of Two-Component Mono-Oxygenases Involved in Anthracycline 1-Hydroxylation  (2024)  
    • ACS Catalysis
     Wandi, Benjamin Nji; Dinis, Pedro; Siitonen, Vilja; Schneider, Gunter; Schnell, Robert; Metsä-Ketelä, Mikko


  • Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines  (2024)  
    • Frontiers in Bioengineering and Biotechnology
     Hulst, Mandy B.; Zhang, Le; van der Heul, Helga U.; Du, Chao; Elsayed, Somayah S.; Koroleva, Arina; Grocholski, Thadee; Wander, Dennis P. A.; Metsä-Ketelä, Mikko; Neefjes, Jacques J. C.; van Wezel, Gilles P.


  • Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates  (2024)  
    • Journal of Biological Chemistry
     Mäkinen, Janne J.; Rosenqvist, Petja; Virta, Pasi; Metsä-Ketelä, Mikko; Belogurov, Georgiy A.


  • Bakteerien avulla antibiootteja mikrobi- ja syöpälääkkeiksi  (2023)  
    • Duodecim
     Metsä-Ketelä Mikko, Siitonen Vilja, Artukka Erika


  • Co-factor independent oxidases ncnN and actVA-3 are involved in the dimerization of benzoisochromanequinone antibiotics in naphthocyclinone and actinorhodin biosynthesis  (2023)  
    • FEMS Microbiology Letters
     Baral Bikash, Matroodi Soheila, Siitonen Vilja, Thapa Keshav, Akhgari Amir, Yamada Keith, Nuutila Aleksi, Metsä-Ketelä Mikko


  • Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins  (2023)  
    • ACS Omega
     Tirkkonen Heli, Brown Katelyn V, Niemczura Magdalena, Faudemer Zélie, Brown Cortney, Ponomareva Larissa V , Helmy Yorsta A, Thorson Jon S, Nybo S Eric, Metsä-Ketelä Mikko, Shaaban Khaled A


  • Evolution-inspired engineering of anthracycline methyltransferases  (2023)  
    • PNAS nexus
     Dinis Pedro, Tirkkonen Heli, Nji Wandi Benjamin N, Siitonen Vilja, Niemi Jarmo, Grocholski Thadée, Metsä-Ketelä Mikko


  • Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway  (2023)  
    • ACS Chemical Biology
     Artukka Erika, Schnell Robert, Palmu Kaisa, Rosenqvist Petja, Szodorai Edit, Niemi Jarmo, Virta Pasi, Schneider Gunter, Metsä-Ketelä Mikko


  • Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis  (2023)  
    • Communications chemistry
     Elsayed Somayah S., van der Heul Helga U., Xiao Xiansha, Nuutila Aleksi, Baars Laura R., Wu Changsheng, Metsä-Ketelä Mikko, van Wezel Gilles P.


  • A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor  (2022)  
    • ACS Synthetic Biology
     Wang Rongbin, Nguyen Jennifer, Hecht Jacob, Schwartz Nora, Brown Katelyn V, Ponomareva Larissa V, Niemczura Magdalena, van Dissel Dino, van Wezel Gilles P, Thorson Jon S, Metsä-Ketelä Mikko, Shaaban Khaled A, Nybo S Eric


  • Anthracyclines: biosynthesis, engineering and clinical applications  (2022)  
    • Natural Product Reports
     Hulst Mandy B., Grocholski Thadee, Neefjes Jacques J.C., van Wezel Gilles P., Metsä-Ketelä Mikko


  • Fluorogenic RNA aptamers to probe transcription initiation and co-transcriptional RNA folding by multi-subunit RNA polymerases  (2022)  Methods in Enzymology Huang Yong-Heng, Trapp Vilma, Puro Oskari, Mäkinen Janne J., Metsä-Ketelä Mikko, Wahl Markus C., Belogurov Georgiy A.


  • Single cell mutant selection for metabolic engineering of actinomycetes  (2022)  
    • Metabolic Engineering
     Akhgari Amir., Baral Bikash, Koroleva Arina, Siitonen Vilja, Fewer David P., Melançon Charles E., Rahkila Jani, Metsä-Ketelä Mikko



Last updated on 12/07/2023 12:21:50 PM