Mikko Metsä-Ketelä

- Professor,
Biochemistry (Department of Life Technologies)

mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku

ABE

Natural products; Streptomyces; biosynthesis

http://abelab.utu.fi

Molecular Biology

Structural Biology

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Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates (2024)
- Journal of Biological Chemistry
Mäkinen, Janne J.; Rosenqvist, Petja; Virta, Pasi; Metsä-Ketelä, Mikko; Belogurov, Georgiy A.
Bakteerien avulla antibiootteja mikrobi- ja syöpälääkkeiksi (2023)
- Duodecim
Metsä-Ketelä Mikko, Siitonen Vilja, Artukka Erika
Co-factor independent oxidases ncnN and actVA-3 are involved in the dimerization of benzoisochromanequinone antibiotics in naphthocyclinone and actinorhodin biosynthesis (2023)
- FEMS Microbiology Letters
Baral Bikash, Matroodi Soheila, Siitonen Vilja, Thapa Keshav, Akhgari Amir, Yamada Keith, Nuutila Aleksi, Metsä-Ketelä Mikko
Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins (2023)
- ACS Omega
Tirkkonen Heli, Brown Katelyn V, Niemczura Magdalena, Faudemer Zélie, Brown Cortney, Ponomareva Larissa V , Helmy Yorsta A, Thorson Jon S, Nybo S Eric, Metsä-Ketelä Mikko, Shaaban Khaled A
Evolution-inspired engineering of anthracycline methyltransferases (2023)
- PNAS nexus
Dinis Pedro, Tirkkonen Heli, Nji Wandi Benjamin N, Siitonen Vilja, Niemi Jarmo, Grocholski Thadée, Metsä-Ketelä Mikko
Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway (2023)
- ACS Chemical Biology
Artukka Erika, Schnell Robert, Palmu Kaisa, Rosenqvist Petja, Szodorai Edit, Niemi Jarmo, Virta Pasi, Schneider Gunter, Metsä-Ketelä Mikko
Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis (2023)
- Communications chemistry
Elsayed Somayah S., van der Heul Helga U., Xiao Xiansha, Nuutila Aleksi, Baars Laura R., Wu Changsheng, Metsä-Ketelä Mikko, van Wezel Gilles P.
A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor (2022)
- ACS Synthetic Biology
Wang Rongbin, Nguyen Jennifer, Hecht Jacob, Schwartz Nora, Brown Katelyn V, Ponomareva Larissa V, Niemczura Magdalena, van Dissel Dino, van Wezel Gilles P, Thorson Jon S, Metsä-Ketelä Mikko, Shaaban Khaled A, Nybo S Eric
Anthracyclines: biosynthesis, engineering and clinical applications (2022)
- Natural Product Reports
Hulst Mandy B., Grocholski Thadee, Neefjes Jacques J.C., van Wezel Gilles P., Metsä-Ketelä Mikko
Fluorogenic RNA aptamers to probe transcription initiation and co-transcriptional RNA folding by multi-subunit RNA polymerases (2022) Methods in Enzymology Huang Yong-Heng, Trapp Vilma, Puro Oskari, Mäkinen Janne J., Metsä-Ketelä Mikko, Wahl Markus C., Belogurov Georgiy A.