Mikko Metsä-Ketelä
 


mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku


ABE

Natural products; Streptomyces; biosynthesis

http://abelab.utu.fi



Molecular Biology

Structural Biology



  
Go to first page
  
Go to previous page
  
1 of 5
  
Go to next page
  
Go to last page
  
  • Functional Plasticity of Methyltransferases in Anthracycline Biosynthesis: A Single Residue Reversal between Decarboxylation and Hydroxylation  (2026)  
    • ACS CatalysisFrontiers in Bioengineering and Biotechnology
     Sang, Moli; Yang, Qingyu; Guo, Jiawei; Feng, Peiyuan; Gao, Yu; Ma, Wencheng; Li, Shengying; Metsä-Ketelä, Mikko; Zhang, Wei


  • Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxAProbing the nucleobase selectivity of RNA polymerases with dual-coding substrates  (2026)  
    • Nature CommunicationsJournal of Biological Chemistry
     Koroleva, Arina; Artukka, Erika; Yamada, Keith; Newmister, Sean A.; Harte, Ralph J.; Boesger, Hannah; Londen, Mikael; Sanders, Jacob N.; Tirkkonen, Heli; Kannisto, Matti; Kuin, Rosan C. M.; Hulst, Mandy; Wang, Rongbin; Leskinen, Ester; Barillec, Morgane; Niemi, Jarmo; van Wezel, Gilles P.; Neefjes, Jacques; Nybo, S. Eric; Houk, Kendall N.; Sherman, David H.; Kim, Robbert Q.; Metsä-Ketelä, Mikko


  • MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaborationBakteerien avulla antibiootteja mikrobi- ja syöpälääkkeiksi  (2025)  
    • Nucleic Acids ResearchDuodecim
     Zdouc, Mitja M.; Blin, Kai; Louwen, Nico L.L.; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D.; Bailey, Constance B.; Barra, Lena; Booth, Thomas J.; Bozhüyük, Kenan A.J.; Cediel-Becerra, José D.D.; Charlop-Powers, Zachary; Chevrette, Marc G.; Chooi, Yit Heng; D’Agostino, Paul M.; de Rond, Tristan; Del Pup, Elena; Duncan, Katherine R.; Gu, Wenjia; Hanif, Novriyandi; Helfrich, Eric J.N.; Jenner, Matthew; Katsuyama, Yohei; Korenskaia, Aleksandra; Krug, Daniel; Libis, Vincent; Lund, George A.; Mantri, Shrikant; Morgan, Kalindi D.; Owen, Charlotte; Phan, Chin-Soon; Philmus, Benjamin; Reitz, Zachary L.; Robinson, Serina L.; Singh, Kumar Saurabh; Teufel, Robin; Tong, Yaojun; Tugizimana, Fidele; Ulanova, Dana; Winter, Jaclyn M.; Aguilar, César; Akiyama, Daniel Y.; Al-Salihi, Suhad A.A.; Alanjary, Mohammad; Alberti, Fabrizio; Aleti, Gajender; Alharthi, Shumukh A.; Rojo, Mariela Y. Arias; Arishi, Amr A.; Augustijn, Hannah E.; Avalon, Nicole E.; Avelar-Rivas, J. Abraham; Axt, Kyle K.; Barbieri, Hellen B.; Barbosa, Julio Cesar J.; Barboza Segato, Lucas Gabriel; Barrett, Susanna E.; Baunach, Martin; Beemelmanns, Christine; Beqaj, Dardan; Berger, Tim; Bernaldo-Agüero, Jordan; Bettenbühl, Sandra M.; Bielinski, Vincent A.; Biermann, Friederike; Borges, Ricardo M.; Borriss, Rainer; Breitenbach, Milena; Bretscher, Kevin M.; Brigham, Michael W.; Buedenbender, Larissa; Bulcock, Brodie W.; Cano-Prieto, Carolina; Capela, João; Carrion, Victor J.; Carter, Riley S.; Castelo-Branco, Raquel; Castro-Falcón, Gabriel; Chagas, Fernanda O.; Charria-Girón, Esteban; Chaudhri, Ayesha Ahmed; Chaudhry, Vasvi; Choi, Hyukjae; Choi, Yukyung; Choupannejad, Roya; Chromy, Jakub; Donahey, Melinda S. Chue; Collemare, Jérôme; Connolly, Jack A.; Creamer, Kaitlin E.; Crüsemann, Max; Cruz, Andres Arredondo; Cumsille, Andres; Dallery, Jean-Felix; Damas-Ramos, Luis Caleb; Damiani, Tito; de Kruijff, Martinus; Martín, Belén Delgado; Sala, Gerardo Della; Dillen, Jelle; Doering, Drew T.; Dommaraju, Shravan R.; Durusu, Suhan; Egbert, Susan; Ellerhorst, Mark; Faussurier, Baptiste; Fetter, Artem; Feuermann, Marc; Fewer, David P.; Foldi, Jonathan; Frediansyah, Andri; Garza, Erin A.; Gavriilidou, Athina; Gentile, Andrea; Gerke, Jennifer; Gerstmans, Hans; Gomez-Escribano, Juan Pablo; González-Salazar, Luz A.; Grayson, Natalie E.; Greco, Claudio; Gomez, Juan E. Gris; Guerra, Sebastian; Flores, Shaday Guerrero; Gurevich, Alexey; Gutiérrez-García, Karina; Hart, Lauren; Haslinger, Kristina; He, Beibei; Hebra, Teo; Hemmann, Jethro L.; Hindra, Hindra; Höing, Lars; Holland, Darren C.; Holme, Jonathan E.; Horch, Therese; Hrab, Pavlo; Hu, Jie; Huynh, Thanh-Hau; Hwang, Ji-Yeon; Iacovelli, Riccardo; Iftime, Dumitrita; Iorio, Marianna; Jayachandran, Sidharth; Jeong, Eunah; Jing, Jiayi; Jung, Jung J.; Kakumu, Yuya; Kalkreuter, Edward; Kang, Kyo Bin; Kang, Sangwook; Kim, Wonyong; Kim, Geum Jin; Kim, Hyunwoo; Kim, Hyun Uk; Klapper, Martin; Koetsier, Robert A.; Kollten, Cassandra; Kovács, Ákos T.; Kriukova, Yelyzaveta; Kubach, Noel; Kunjapur, Aditya M.; Kushnareva, Aleksandra K.; Kust, Andreja; Lamber, Jessica; Larralde, Martin; Larsen, Niels J.; Launay, Adrien P.; Le, Ngoc-Thao-Hien; Lebeer, Sarah; Lee, Byung Tae; Lee, Kyungha; Lev, Katherine L.; Li, Shu-Ming; Li, Yong-Xin; Licona-Cassani, Cuauhtémoc; Lien, Annette; Liu, Jing; Lopez, Julius Adam V.; Machushynets, Nataliia V.; Macias, Marla I.; Mahmud, Taifo; Maleckis, Matiss; Martinez-Martinez, Añadir Maharai; Mast, Yvonne; Maximo, Marina F.; McBride, Christina M.; McLellan, Rose M.; Bhatt, Khyati Mehta; Melkonian, Chrats; Merrild, Aske; Metsä-Ketelä, Mikko; Mitchell, Douglas A.; Müller, Alison V.; Nguyen, Giang-Son; Nguyen, Hera T.; Niedermeyer, Timo H.J.; O’Hare, Julia H.; Ossowicki, Adam; Ostash, Bohdan O.; Otani, Hiroshi; Padva, Leo; Paliyal, Sunaina; Pan, Xinya; Panghal, Mohit; Parade, Dana S.; Park, Jiyoon; Parra, Jonathan; Rubio, Marcos Pedraza; Pham, Huong T.; Pidot, Sacha J.; Piel, Jörn; Pourmohsenin, Bita; Rakhmanov, Malik; Ramesh, Sangeetha; Rasmussen, Michelle H.; Rego, Adriana; Reher, Raphael; Rice, Andrew J.; Rigolet, Augustin; Romero-Otero, Adriana; Rosas-Becerra, Luis Rodrigo; Rosiles, Pablo Y.; Rutz, Adriano; Ryu, Byeol; Sahadeo, Libby-Ann; Saldanha, Murrel; Salvi, Luca; Sánchez-Carvajal, Eduardo; Santos-Medellin, Christian; Sbaraini, Nicolau; Schoellhorn, Sydney M.; Schumm, Clemens; Sehnal, Ludek; Selem, Nelly; Shah, Anjali D.; Shishido, Tania K.; Sieber, Simon; Silviani, Velina; Singh, Garima; Singh, Hemant; Sokolova, Nika; Sonnenschein, Eva C.; Sosio, Margherita; Sowa, Sven T.; Steffen, Karin; Stegmann, Evi; Streiff, Alena B.; Strüder, Alena; Surup, Frank; Svenningsen, Tiziana; Sweeney, Douglas; Szenei, Judit; Tagirdzhanov, Azat; Tan, Bin; Tarnowski, Matthew J.; Terlouw, Barbara R.; Rey, Thomas; Thome, Nicola U.; Torres Ortega, Laura Rosina; Tørring, Thomas; Trindade, Marla; Truman, Andrew W.; Tvilum, Marie; Udwary, Daniel W.; Ulbricht, Christoph; Vader, Lisa; van Wezel, Gilles P.; Walmsley, Max; Warnasinghe, Randika; Weddeling, Heiner G.; Weir, Angus N.M.; Williams, Katherine; Williams, Sam E.; Witte, Thomas E.; Rocca, Steffaney M. Wood; Yamada, Keith; Yang, Dong; Yang, Dongsoo; Yu, Jingwei; Zhou, Zhenyi; Ziemert, Nadine; Zimmer, Lukas; Zimmermann, Alina; Zimmermann, Christian; van der Hooft, Justin J.J.; Linington, Roger G.; Weber, Tilmann; Medema, Marnix H.


  • Three-Enzyme Cascade Catalyzes Conversion of Auramycinone to Resomycin in Chartreusin Biosynthesis  (2025)  
    • ACS Chemical BiologyFEMS Microbiology Letters
     Niemczura, Magdalena; Nuutila, Aleksi; Wang, Rongbin; Rauhanen, Katariina; Nybo, S. Eric; Metsä-Ketelä, Mikko


  • ActVI-ORFA directs metabolic flux towards actinorhodin by preventing intermediate degradationPseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway  (2024)  
    • PLoS ONEACS OmegaACS Chemical Biology
     Zhu, Xuechen; Wang, Rongbin; Siitonen, Vilja; Vuksanovic, Nemanja; Silvaggi, Nicholas R.; Melançon III, Charles E.; Metsä-Ketelä, Mikko


  • Divergence of Classical and C-Ring-Cleaved Angucyclines : Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis  (2024)  
    • ACS Chemical BiologyPNAS nexus
     Nuutila, Aleksi; Xiao, Xiansha; van der Heul, Helga U.; van Wezel, Gilles P.; Dinis, Pedro; Elsayed, Somayah S.; Metsä-Ketelä, Mikko


  • Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones  (2024)  
    • ACS Synthetic BiologyCommunications chemistry
     Wang, Rongbin; Nji Wandi, Benjamin; Schwartz, Nora; Hecht, Jacob; Ponomareva, Larissa; Paige, Kendall; West, Alexis; Desanti, Kathryn; Nguyen, Jennifer; Niemi, Jarmo; Thorson, Jon S.; Shaaban, Khaled A.; Metsä-Ketelä, Mikko; Nybo, S. Eric


  • Mechanism of Two-Component Mono-Oxygenases Involved in Anthracycline 1-HydroxylationUnravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis  (2024)  
    • ACS Catalysis
     Wandi, Benjamin Nji; Dinis, Pedro; Siitonen, Vilja; Schneider, Gunter; Schnell, Robert; Metsä-Ketelä, Mikko


  • Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclinesA BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolorAnthracyclines: biosynthesis, engineering and clinical applications  (2024)  
       Hulst, Mandy B.; Zhang, Le; van der Heul, Helga U.; Du, Chao; Elsayed, Somayah S.; Koroleva, Arina; Grocholski, Thadee; Wander, Dennis P. A.; Metsä-Ketelä, Mikko; Neefjes, Jacques J. C.; van Wezel, Gilles P.


    •   (2024)  
         Mäkinen, Janne J.; Rosenqvist, Petja; Virta, Pasi; Metsä-Ketelä, Mikko; Belogurov, Georgiy A.


      •   (2023)  
           Metsä-Ketelä Mikko, Siitonen Vilja, Artukka Erika


        • Co-factor independent oxidases ncnN and actVA-3 are involved in the dimerization of benzoisochromanequinone antibiotics in naphthocyclinone and actinorhodin biosynthesisSingle cell mutant selection for metabolic engineering of actinomycetes  (2023)  
             Baral Bikash, Matroodi Soheila, Siitonen Vilja, Thapa Keshav, Akhgari Amir, Yamada Keith, Nuutila Aleksi, Metsä-Ketelä Mikko


          • Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins  (2023)  
               Tirkkonen Heli, Brown Katelyn V, Niemczura Magdalena, Faudemer Zélie, Brown Cortney, Ponomareva Larissa V , Helmy Yorsta A, Thorson Jon S, Nybo S Eric, Metsä-Ketelä Mikko, Shaaban Khaled A


            • Evolution-inspired engineering of anthracycline methyltransferases  (2023)  
                 Dinis Pedro, Tirkkonen Heli, Nji Wandi Benjamin N, Siitonen Vilja, Niemi Jarmo, Grocholski Thadée, Metsä-Ketelä Mikko


              •   (2023)  
                   Artukka Erika, Schnell Robert, Palmu Kaisa, Rosenqvist Petja, Szodorai Edit, Niemi Jarmo, Virta Pasi, Schneider Gunter, Metsä-Ketelä Mikko


                •   (2023)  
                     Elsayed Somayah S., van der Heul Helga U., Xiao Xiansha, Nuutila Aleksi, Baars Laura R., Wu Changsheng, Metsä-Ketelä Mikko, van Wezel Gilles P.


                  • 2022
                    • ACS Synthetic Biology
                     Wang Rongbin, Nguyen Jennifer, Hecht Jacob, Schwartz Nora, Brown Katelyn V, Ponomareva Larissa V, Niemczura Magdalena, van Dissel Dino, van Wezel Gilles P, Thorson Jon S, Metsä-Ketelä Mikko, Shaaban Khaled A, Nybo S Eric


                  •   (2022)  
                    • Natural Product Reports
                     Hulst Mandy B., Grocholski Thadee, Neefjes Jacques J.C., van Wezel Gilles P., Metsä-Ketelä Mikko


                  • Fluorogenic RNA aptamers to probe transcription initiation and co-transcriptional RNA folding by multi-subunit RNA polymerases  (2022)  Methods in Enzymology Huang Yong-Heng, Trapp Vilma, Puro Oskari, Mäkinen Janne J., Metsä-Ketelä Mikko, Wahl Markus C., Belogurov Georgiy A.


                  •   (2022)  
                    • Metabolic Engineering
                     Akhgari Amir., Baral Bikash, Koroleva Arina, Siitonen Vilja, Fewer David P., Melançon Charles E., Rahkila Jani, Metsä-Ketelä Mikko


                  Last updated on 12/07/2023 12:21:50 PM