Mikko Metsä-Ketelä
 

    • Professor, 
    • Associate Professor
    • Academy Research Fellow
    • Senior Researcher
    • Docent
    • University Lecturer
    Biochemistry (Department of Life Technologies)


mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku


ABE

Natural products; Streptomyces; biosynthesis

http://abelab.utu.fi



Molecular Biology

Structural Biology



  
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  • MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration  (2025)  
    • Nucleic Acids Research
     Zdouc, Mitja M.; Blin, Kai; Louwen, Nico L.L.; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D.; Bailey, Constance B.; Barra, Lena; Booth, Thomas J.; Bozhüyük, Kenan A.J.; Cediel-Becerra, José D.D.; Charlop-Powers, Zachary; Chevrette, Marc G.; Chooi, Yit Heng; D’Agostino, Paul M.; de Rond, Tristan; Del Pup, Elena; Duncan, Katherine R.; Gu, Wenjia; Hanif, Novriyandi; Helfrich, Eric J.N.; Jenner, Matthew; Katsuyama, Yohei; Korenskaia, Aleksandra; Krug, Daniel; Libis, Vincent; Lund, George A.; Mantri, Shrikant; Morgan, Kalindi D.; Owen, Charlotte; Phan, Chin-Soon; Philmus, Benjamin; Reitz, Zachary L.; Robinson, Serina L.; Singh, Kumar Saurabh; Teufel, Robin; Tong, Yaojun; Tugizimana, Fidele; Ulanova, Dana; Winter, Jaclyn M.; Aguilar, César; Akiyama, Daniel Y.; Al-Salihi, Suhad A.A.; Alanjary, Mohammad; Alberti, Fabrizio; Aleti, Gajender; Alharthi, Shumukh A.; Rojo, Mariela Y. Arias; Arishi, Amr A.; Augustijn, Hannah E.; Avalon, Nicole E.; Avelar-Rivas, J. Abraham; Axt, Kyle K.; Barbieri, Hellen B.; Barbosa, Julio Cesar J.; Barboza Segato, Lucas Gabriel; Barrett, Susanna E.; Baunach, Martin; Beemelmanns, Christine; Beqaj, Dardan; Berger, Tim; Bernaldo-Agüero, Jordan; Bettenbühl, Sandra M.; Bielinski, Vincent A.; Biermann, Friederike; Borges, Ricardo M.; Borriss, Rainer; Breitenbach, Milena; Bretscher, Kevin M.; Brigham, Michael W.; Buedenbender, Larissa; Bulcock, Brodie W.; Cano-Prieto, Carolina; Capela, João; Carrion, Victor J.; Carter, Riley S.; Castelo-Branco, Raquel; Castro-Falcón, Gabriel; Chagas, Fernanda O.; Charria-Girón, Esteban; Chaudhri, Ayesha Ahmed; Chaudhry, Vasvi; Choi, Hyukjae; Choi, Yukyung; Choupannejad, Roya; Chromy, Jakub; Donahey, Melinda S. Chue; Collemare, Jérôme; Connolly, Jack A.; Creamer, Kaitlin E.; Crüsemann, Max; Cruz, Andres Arredondo; Cumsille, Andres; Dallery, Jean-Felix; Damas-Ramos, Luis Caleb; Damiani, Tito; de Kruijff, Martinus; Martín, Belén Delgado; Sala, Gerardo Della; Dillen, Jelle; Doering, Drew T.; Dommaraju, Shravan R.; Durusu, Suhan; Egbert, Susan; Ellerhorst, Mark; Faussurier, Baptiste; Fetter, Artem; Feuermann, Marc; Fewer, David P.; Foldi, Jonathan; Frediansyah, Andri; Garza, Erin A.; Gavriilidou, Athina; Gentile, Andrea; Gerke, Jennifer; Gerstmans, Hans; Gomez-Escribano, Juan Pablo; González-Salazar, Luz A.; Grayson, Natalie E.; Greco, Claudio; Gomez, Juan E. Gris; Guerra, Sebastian; Flores, Shaday Guerrero; Gurevich, Alexey; Gutiérrez-García, Karina; Hart, Lauren; Haslinger, Kristina; He, Beibei; Hebra, Teo; Hemmann, Jethro L.; Hindra, Hindra; Höing, Lars; Holland, Darren C.; Holme, Jonathan E.; Horch, Therese; Hrab, Pavlo; Hu, Jie; Huynh, Thanh-Hau; Hwang, Ji-Yeon; Iacovelli, Riccardo; Iftime, Dumitrita; Iorio, Marianna; Jayachandran, Sidharth; Jeong, Eunah; Jing, Jiayi; Jung, Jung J.; Kakumu, Yuya; Kalkreuter, Edward; Kang, Kyo Bin; Kang, Sangwook; Kim, Wonyong; Kim, Geum Jin; Kim, Hyunwoo; Kim, Hyun Uk; Klapper, Martin; Koetsier, Robert A.; Kollten, Cassandra; Kovács, Ákos T.; Kriukova, Yelyzaveta; Kubach, Noel; Kunjapur, Aditya M.; Kushnareva, Aleksandra K.; Kust, Andreja; Lamber, Jessica; Larralde, Martin; Larsen, Niels J.; Launay, Adrien P.; Le, Ngoc-Thao-Hien; Lebeer, Sarah; Lee, Byung Tae; Lee, Kyungha; Lev, Katherine L.; Li, Shu-Ming; Li, Yong-Xin; Licona-Cassani, Cuauhtémoc; Lien, Annette; Liu, Jing; Lopez, Julius Adam V.; Machushynets, Nataliia V.; Macias, Marla I.; Mahmud, Taifo; Maleckis, Matiss; Martinez-Martinez, Añadir Maharai; Mast, Yvonne; Maximo, Marina F.; McBride, Christina M.; McLellan, Rose M.; Bhatt, Khyati Mehta; Melkonian, Chrats; Merrild, Aske; Metsä-Ketelä, Mikko; Mitchell, Douglas A.; Müller, Alison V.; Nguyen, Giang-Son; Nguyen, Hera T.; Niedermeyer, Timo H.J.; O’Hare, Julia H.; Ossowicki, Adam; Ostash, Bohdan O.; Otani, Hiroshi; Padva, Leo; Paliyal, Sunaina; Pan, Xinya; Panghal, Mohit; Parade, Dana S.; Park, Jiyoon; Parra, Jonathan; Rubio, Marcos Pedraza; Pham, Huong T.; Pidot, Sacha J.; Piel, Jörn; Pourmohsenin, Bita; Rakhmanov, Malik; Ramesh, Sangeetha; Rasmussen, Michelle H.; Rego, Adriana; Reher, Raphael; Rice, Andrew J.; Rigolet, Augustin; Romero-Otero, Adriana; Rosas-Becerra, Luis Rodrigo; Rosiles, Pablo Y.; Rutz, Adriano; Ryu, Byeol; Sahadeo, Libby-Ann; Saldanha, Murrel; Salvi, Luca; Sánchez-Carvajal, Eduardo; Santos-Medellin, Christian; Sbaraini, Nicolau; Schoellhorn, Sydney M.; Schumm, Clemens; Sehnal, Ludek; Selem, Nelly; Shah, Anjali D.; Shishido, Tania K.; Sieber, Simon; Silviani, Velina; Singh, Garima; Singh, Hemant; Sokolova, Nika; Sonnenschein, Eva C.; Sosio, Margherita; Sowa, Sven T.; Steffen, Karin; Stegmann, Evi; Streiff, Alena B.; Strüder, Alena; Surup, Frank; Svenningsen, Tiziana; Sweeney, Douglas; Szenei, Judit; Tagirdzhanov, Azat; Tan, Bin; Tarnowski, Matthew J.; Terlouw, Barbara R.; Rey, Thomas; Thome, Nicola U.; Torres Ortega, Laura Rosina; Tørring, Thomas; Trindade, Marla; Truman, Andrew W.; Tvilum, Marie; Udwary, Daniel W.; Ulbricht, Christoph; Vader, Lisa; van Wezel, Gilles P.; Walmsley, Max; Warnasinghe, Randika; Weddeling, Heiner G.; Weir, Angus N.M.; Williams, Katherine; Williams, Sam E.; Witte, Thomas E.; Rocca, Steffaney M. Wood; Yamada, Keith; Yang, Dong; Yang, Dongsoo; Yu, Jingwei; Zhou, Zhenyi; Ziemert, Nadine; Zimmer, Lukas; Zimmermann, Alina; Zimmermann, Christian; van der Hooft, Justin J.J.; Linington, Roger G.; Weber, Tilmann; Medema, Marnix H.


  •   (2025)  
    • ACS Chemical BiologyJournal of Biological Chemistry
     Niemczura, Magdalena; Nuutila, Aleksi; Wang, Rongbin; Rauhanen, Katariina; Nybo, S. Eric; Metsä-Ketelä, Mikko


  • ActVI-ORFA directs metabolic flux towards actinorhodin by preventing intermediate degradation  (2024)  
    • PLoS ONE
     Zhu, Xuechen; Wang, Rongbin; Siitonen, Vilja; Vuksanovic, Nemanja; Silvaggi, Nicholas R.; Melançon III, Charles E.; Metsä-Ketelä, Mikko


  • Divergence of Classical and C-Ring-Cleaved Angucyclines : Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis  (2024)  
    • ACS Chemical BiologyFEMS Microbiology Letters
     Nuutila Aleksi, Xiao Xiansha, van der Heul Helga U., van Wezel Gilles P., Dinis Pedro, Elsayed Somayah S., Metsä-Ketelä Mikko


  • Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones  (2024)  
    • ACS Synthetic Biology
     Wang Rongbin, Nji Wandi Benjamin, Schwartz Nora, Hecht Jacob, Ponomareva Larissa, Paige Kendall, West Alexis, Desanti Kathryn, Nguyen Jennifer, Niemi Jarmo, Thorson Jon S., Shaaban Khaled A., Metsä-Ketelä Mikko, Nybo S. Eric


  • Mechanism of Two-Component Mono-Oxygenases Involved in Anthracycline 1-Hydroxylation  (2024)  
    • ACS CatalysisPNAS nexus
     Wandi, Benjamin Nji; Dinis, Pedro; Siitonen, Vilja; Schneider, Gunter; Schnell, Robert; Metsä-Ketelä, Mikko


  • Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines  (2024)  
    • Frontiers in Bioengineering and Biotechnology
     Hulst Mandy B., Zhang Le, van der Heul Helga U., Du Chao, Elsayed Somayah S., Koroleva Arina, Grocholski Thadee, Wander Dennis P. A., Metsa-Ketela Mikko, Neefjes Jacques J. C., van Wezel Gilles P.


  • Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates  (2024)  
       Mäkinen, Janne J.; Rosenqvist, Petja; Virta, Pasi; Metsä-Ketelä, Mikko; Belogurov, Georgiy A.


    • Bakteerien avulla antibiootteja mikrobi- ja syöpälääkkeiksi2023
      • DuodecimCommunications chemistry
       Metsä-Ketelä Mikko, Siitonen Vilja, Artukka Erika


    • Co-factor independent oxidases ncnN and actVA-3 are involved in the dimerization of benzoisochromanequinone antibiotics in naphthocyclinone and actinorhodin biosynthesis  (2023)  
         Baral Bikash, Matroodi Soheila, Siitonen Vilja, Thapa Keshav, Akhgari Amir, Yamada Keith, Nuutila Aleksi, Metsä-Ketelä Mikko


      • Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins  (2023)  
        • ACS Omega
         Tirkkonen Heli, Brown Katelyn V, Niemczura Magdalena, Faudemer Zélie, Brown Cortney, Ponomareva Larissa V , Helmy Yorsta A, Thorson Jon S, Nybo S Eric, Metsä-Ketelä Mikko, Shaaban Khaled A


      • Evolution-inspired engineering of anthracycline methyltransferases  (2023)  
           Dinis Pedro, Tirkkonen Heli, Nji Wandi Benjamin N, Siitonen Vilja, Niemi Jarmo, Grocholski Thadée, Metsä-Ketelä Mikko


        • Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway  (2023)  
          • ACS Chemical Biology
           Artukka Erika, Schnell Robert, Palmu Kaisa, Rosenqvist Petja, Szodorai Edit, Niemi Jarmo, Virta Pasi, Schneider Gunter, Metsä-Ketelä Mikko


        • Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis  (2023)  
             Elsayed Somayah S., van der Heul Helga U., Xiao Xiansha, Nuutila Aleksi, Baars Laura R., Wu Changsheng, Metsä-Ketelä Mikko, van Wezel Gilles P.


          •   (2022)  
            • ACS Synthetic BiologyEuropean Journal of Medicinal Chemistry
             Wang Rongbin, Nguyen Jennifer, Hecht Jacob, Schwartz Nora, Brown Katelyn V, Ponomareva Larissa V, Niemczura Magdalena, van Dissel Dino, van Wezel Gilles P, Thorson Jon S, Metsä-Ketelä Mikko, Shaaban Khaled A, Nybo S Eric


          • Anthracyclines: biosynthesis, engineering and clinical applications  (2022)  
            • Natural Product ReportsACS Synthetic Biology
             Hulst Mandy B., Grocholski Thadee, Neefjes Jacques J.C., van Wezel Gilles P., Metsä-Ketelä Mikko


          • Fluorogenic RNA aptamers to probe transcription initiation and co-transcriptional RNA folding by multi-subunit RNA polymerases  (2022)  Methods in Enzymology Huang Yong-Heng, Trapp Vilma, Puro Oskari, Mäkinen Janne J., Metsä-Ketelä Mikko, Wahl Markus C., Belogurov Georgiy A.


          • Single cell mutant selection for metabolic engineering of actinomycetes  (2022)  
            • Metabolic Engineering
             Akhgari Amir., Baral Bikash, Koroleva Arina, Siitonen Vilja, Fewer David P., Melançon Charles E., Rahkila Jani, Metsä-Ketelä Mikko


          • The role of the maleimide ring system on the structure-activity relationship of showdomycin  (2022)  
               Rosenqvist Petja, Mäkinen Janne J, Palmu Kaisa, Jokinen Johanna, Prajapati Ranjit K, Korhonen Heidi J, Virta Pasi, Belogurov Georgiy A, Metsä-Ketelä Mikko


            • Biosynthesis of Diverse Type II Polyketide Core Structures in Streptomyces coelicolor M1152  (2021)  
                 Zhu Xuechen, Siitonen Vilja, Melancon III Charles E, Metsä-Ketelä Mikko



              Last updated on 12/07/2023 12:21:50 PM