Mikko Metsä-Ketelä
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mianme@utu.fi
+358 29 450 4786
+358 50 436 6523
Tykistökatu 6
Turku
ABE
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Areas of expertise
Natural products; Streptomyces; biosynthesis
Research
http://abelab.utu.fi
Teaching
Molecular Biology
Structural Biology
Publications
- Enzymatic Synthesis of the C-glycosidic Moiety of Nogalamycin R (2018) Siitonen Vilja, Nji Wandi Benjamin, Törmänen Akke-Pekka, Metsä-Ketelä Mikko
(A1 Refereed original research article in a scientific journal)
- Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics (2017) Kaisa Palmu, Petja Rosenqvist, Keshav Thapa, Yulia Ilina, Vilja Siitonen, Bikash Baral, Janne Mäkinen, Georgi Belogurov, Pasi Virta, Jarmo Niemi, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
- Evolution inspired engineering of antibiotic biosynthesis enzymes (2017)
- Organic and Biomolecular Chemistry
M. Metsä-Ketelä
(A2 Refereed review article in a scientific journal )
- Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway (2016)
- Proceedings of the National Academy of Sciences of the United States of America
Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
- Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE (2016) Jackson DR, Yu X, Wang GJ, Patel AB, Calveras J, Barajas JF, Sasaki E, Metsa-Ketela M, Liu HW, Rohr J, Tsai SC
(A1 Refereed original research article in a scientific journal)
- Laboratory course on Streptomyces genetics and secondary metabolism (2016)
- Biochemistry and Molecular Biology Education
Siitonen V, Raty K, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
- Divergent evolution of an atypical S-adenosyl-L-methionine-dependent monooxygenase involved in anthracycline biosynthesis (2015)
- Proceedings of the National Academy of Sciences of the United States of America
Thadée Grocholski, Pedro Dinis, Laila Niiranen, Jarmo Niemi, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
- Effective Antibiofilm Polyketides against Staphylococcus aureus from the Pyranonaphthoquinone Biosynthetic Pathways of Streptomyces Species (2015)
- Antimicrobial Agents and Chemotherapy
Terhi Oja, Paola San Martin Galindo, Takaaki Taguchi, Suvi Manner, Pia M. Vuorela, Koji Ichinose, Mikko Metsä-Ketelä, Adyary Fallarero
(A1 Refereed original research article in a scientific journal)
- Minimum Information about a Biosynthetic Gene cluster (2015) Marnix H Medema, Renzo Kottmann, Pelin Yilmaz,Matthew Cummings, John B Biggins, Kai Blin, Irene de Bruijn,Yit Heng Chooi, Jan Claesen, R Cameron Coates, Pablo Cruz-Morales, Srikanth Duddela, Stephanie Düsterhus, Daniel J Edwards, David P Fewer, Neha Garg, Christoph Geiger, Juan Pablo Gomez-Escribano, Anja Greule,Michalis Hadjithomas, Anthony S Haines, Eric J N Helfrich, Matthew L Hillwig, Keishi Ishida, Adam C Jones, Carla S Jones, Katrin Jungmann, Carsten Kegler, Hyun Uk Kim, Peter Kötter, Daniel Krug, Joleen Masschelein, Alexey V Melnik, Simone M Mantovani, Emily A Monroe, Marcus Moore, Nathan Moss, Hans-Wilhelm Nützmann, Guohui Pan, Amrita Pati, Daniel Petras, F Jerry Reen, Federico Rosconi, Zhe Rui, Zhenhua Tian, Nicholas J Tobias, Yuta Tsunematsu, Philipp Wiemann, Elizabeth Wyckoff, Xiaohui Yan, Grace Yim, Fengan Yu, Yunchang Xie, Bertrand Aigle, Alexander K Apel, Carl J Balibar, Emily P Balskus, Francisco Barona-Gómez, Andreas Bechthold, Helge B Bode, Rainer Borriss, Sean F Brady, Axel A Brakhage, Png Cheng, Jon Clardy, Russell J Cox, René De Mot, Stefano Donadio, Mohamed S Donia, Wilfred A van der Donk, Pieter C Dorrestein, Sean Doyle, Arnold J M Driessen, Monika Ehling-Schulz, Karl-Dieter Entian, Michael A Fischbach, Lena Gerwick, William H Gerwick, Harald Gross, Bertolt Gust, Christian Hertweck, Monica Höfte, Susan E Jensen, Jianhua Ju, Leonard Katz, Leonard Kaysser, Jonathan L Klassen, Nancy P Keller, Jan Kormanec, Oscar P Kuipers, Tomohisa Kuzuyama, Nikos C Kyrpides, Hyung-Jin Kwon, Sylvie Lautru, Rob Lavigne, Chia Y Lee, Bai Linquan, Xinyu Liu, Wen Liu, Andriy Luzhetskyy, Taifo Mahmud, Yvonne Mast, Carmen Méndez, Mikko Metsä-Ketelä, Jason Micklefield, Douglas A Mitchell, Bradley S Moore, Leonilde M Moreira, Rolf Müller, Brett A Neilan, Markus Nett, Jens Nielsen, Fergal O'Gara, Hideaki Oikawa, Anne Osbourn, Marcia S Osburne, Bohdan Ostash, Shelley M Payne, Jean-Luc Pernodet, Miroslav Petricek, Jörn Piel, Olivier Ploux, Jos M Raaijmakers, José A Salas, Esther K Schmitt, Barry Scott, Ryan F Seipke, Ben Shen, David H Sherman, Kaarina Sivonen, Michael J Smanski, Margherita Sosio, Evi Stegmann, Roderich D Süssmuth, Kapil Tahlan, Christopher M Thomas, Yi Tang, Andrew W Truman, Muriel Viaud, Jonathan D Walton,Christopher T Walsh, Tilmann Weber, Gilles P van Wezel, Barrie Wilkinson, Joanne M Willey, Wolfgang Wohlleben, Gerard D Wright, Nadine Ziemert, Changsheng Zhang, Sergey B Zotchev, Rainer Breitling, Eriko Takano, Frank Oliver Glöckner
(A1 Refereed original research article in a scientific journal)
- Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection (2015) Guo F, Xiang SH, Li LY, Wang B, Rajasarkka J, Grondahl-Yli-Hannuksela K, Ai GM, Metsa-Ketela M, Yang KG
(A1 Refereed original research article in a scientific journal)
