Mikko Metsä-Ketelä

- Professor,
Biochemistry (Department of Life Technologies)

mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku

ABE

Areas of expertise

Natural products; Streptomyces; biosynthesis

Research

http://abelab.utu.fi

Teaching

Molecular Biology

Structural Biology

Publications

4 of 4

Discovery of a Two-Component Monooxygenase SnoaW/SnoaL2 Involved in Nogalamycin Biosynthesis (2012)
- Chemistry and Biology
Siitonen V, Blauenburg B, Kallio P, Mantsala P, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Epimers vs. inverse epimers: the C-1 configuration in alnumycin A1 (2012)
- RSC Advances
Tahtinen P, Oja T, Dreiack N, Mantsala P, Niemi J, Metsa-Ketela M, Klika KD
(A1 Refereed original research article in a scientific journal)
Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone (2012) Bastian Blunenburg, Mikko Metsä-Ketelä, Karel D Klika
(A1 Refereed original research article in a scientific journal)
Identification of Late-Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin (2012)
- ChemBioChem
Siitonen V, Claesson M, Patrikainen P, Aromaa M, Mantsala P, Schneider G, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities (2012)
- Chemistry and Biology
Patrikainen P, Kallio P, Fan KQ, Klika KD, Shaaban KA, Mantsala P, Rohr J, Yang KQ, Niemi J, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
The potential of VCD to resolve the epimer vs. inverse epimer quandary (2012)
- Computational and Theoretical Chemistry
Klika KD, Tahtinen P, Mantsala P, Niemi J, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Flavoprotein Hydroxylase PgaE Catalyzes Two Consecutive Oxygen-Dependent Tailoring Reactions in Angucycline Biosynthesis (2011)
- Biochemistry
Kallio P, Patrikainen P, Suomela JP, Mantsala P, Metsa-Ketela M, Niemi J
(A1 Refereed original research article in a scientific journal)
Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives (2009)
- Journal of Biotechnology
Xu ZL, Metsa-Ketela M, Hertweck C
(A1 Refereed original research article in a scientific journal)
A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation (2008) Kallio P, Liu ZL, Mantsala P, Niemi J, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Anthracycline biosynthesis: Genes, enzymes and mechanisms (2008)
- Topics in Current Chemistry
Metsa-Ketela M, Niemi J, Mantsala P, Schneider G
(C1 Refereed scientific book)
Biosynthetic anthracycline variants (2008)
- Topics in Current Chemistry
Niemi J, Metsa-Ketela M, Schneider G, Mantsala P
(C1 Refereed scientific book)
Characterization of the Alnumycin Gene Cluster Reveals Unusual Gene Products for Pyran Ring Formation and Dioxan Biosynthesis (2008)
- Chemistry and Biology
Oja T, Palmu K, Lehmussola H, Lepparanta O, Hannikainen K, Niemi J, Mantsala P, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: Chemoenzymatic synthesis of gaudimycin C (2008)
- Chemistry and Biology
Kallio P, Liu ZL, Mantsala P, Niemi J, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Artificial reconstruction of two cryptic anglucycline antibiotic Biosynthetic pathways (2007)
- ChemBioChem
Palmu K, Ishida K, Mantsala P, Hertweck C, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis (2007)
- Journal of Molecular Biology
Koskiniemi H, Metsa-Ketela M, Dobritzsch D, Kallio P, Korhonen H, Mantsala P, Schneider G, Niemi J
(A1 Refereed original research article in a scientific journal)
Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis (2007) Koskiniemi H, Metsa-Ketela M, Dobritzsch D, Kallio P, Korhonen H, Mantsala P, Schneider G, Niemi J
(A1 Refereed original research article in a scientific journal)
Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp PGA64 (2004)
- Journal of Antibiotics
Metsa-Ketela M, Ylihonko K, Mantsala P
(A1 Refereed original research article in a scientific journal)
Engineering anthracycline biosynthesis toward angucyclines (2003)
- Antimicrobial Agents and Chemotherapy
Metsa-Ketela M, Palmu K, Kunnari T, Ylihonko K, Mantsala P
(A1 Refereed original research article in a scientific journal)
Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species (2002)
- Applied and Environmental Microbiology
Metsa-Ketela M, Halo L, Munukka E, Hakala J, Mantsala P, Ylihonko K
(A1 Refereed original research article in a scientific journal)
An efficient approach for screening minimal PKS genes from Streptomyces (1999)
- FEMS Microbiology Letters
Metsa-Ketela M, Salo V, Halo L, Hautala A, Hakala J, Mantsala P, Ylihonko K
(A1 Refereed original research article in a scientific journal)