A2 Refereed review article in a scientific journal

Pathway engineering of anthracyclines: Blazing trails in natural product glycodiversification




AuthorsKatelyn V. Brown, Benjamin Nji Wandi, Mikko Metsä-Ketelä, S. Eric Nybo

PublisherAmerican Chemical Society

Publication year2020

JournalJournal of Organic Chemistry

eISSN1520-6904

DOIhttps://doi.org/10.1021/acs.joc.0c01863(external)

Self-archived copy’s web addresshttps://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7541800&blobtype=pdf(external)


Abstract

The anthracyclines are structurally diverse anticancer natural products
that bind to DNA and poison the topoisomerase II – DNA complex in cancer
cells. Rational modifications in the deoxysugar functionality are
especially advantageous for synthesizing drugs with improved potency.
Combinatorial biosynthesis of glycosyltransferases and deoxysugar
synthesis enzymes is indispensable for the generation of
glycodiversified anthracyclines. This Synopsis considers recent advances
in glycosyltransferase structural biology and site-directed
mutagenesis, pathway engineering, and deoxysugar combinatorial
biosynthesis with a focus on generation of “new-to-nature" anthracycline
analogs.



Last updated on 2024-26-11 at 21:18