Mikko Metsä-Ketelä

- Professor,
Biochemistry (Department of Life Technologies)

mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku

ABE

Areas of expertise

Natural products; Streptomyces; biosynthesis

Research

http://abelab.utu.fi

Teaching

Molecular Biology

Structural Biology

Publications

3 of 4

Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway (2016)
- Proceedings of the National Academy of Sciences of the United States of America
Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE (2016)
- ACS Chemical Biology
Jackson DR, Yu X, Wang GJ, Patel AB, Calveras J, Barajas JF, Sasaki E, Metsa-Ketela M, Liu HW, Rohr J, Tsai SC
(A1 Refereed original research article in a scientific journal)
Laboratory course on Streptomyces genetics and secondary metabolism (2016)
- Biochemistry and Molecular Biology Education
Siitonen V, Raty K, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Divergent evolution of an atypical S-adenosyl-L-methionine-dependent monooxygenase involved in anthracycline biosynthesis (2015)
- Proceedings of the National Academy of Sciences of the United States of America
Thadée Grocholski, Pedro Dinis, Laila Niiranen, Jarmo Niemi, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Effective Antibiofilm Polyketides against Staphylococcus aureus from the Pyranonaphthoquinone Biosynthetic Pathways of Streptomyces Species (2015)
- Antimicrobial Agents and Chemotherapy
Terhi Oja, Paola San Martin Galindo, Takaaki Taguchi, Suvi Manner, Pia M. Vuorela, Koji Ichinose, Mikko Metsä-Ketelä, Adyary Fallarero
(A1 Refereed original research article in a scientific journal)
Minimum Information about a Biosynthetic Gene cluster (2015)
- Nature Chemical Biology
Marnix H Medema, Renzo Kottmann, Pelin Yilmaz,Matthew Cummings, John B Biggins, Kai Blin, Irene de Bruijn,Yit Heng Chooi, Jan Claesen, R Cameron Coates, Pablo Cruz-Morales, Srikanth Duddela, Stephanie Düsterhus, Daniel J Edwards, David P Fewer, Neha Garg, Christoph Geiger, Juan Pablo Gomez-Escribano, Anja Greule,Michalis Hadjithomas, Anthony S Haines, Eric J N Helfrich, Matthew L Hillwig, Keishi Ishida, Adam C Jones, Carla S Jones, Katrin Jungmann, Carsten Kegler, Hyun Uk Kim, Peter Kötter, Daniel Krug, Joleen Masschelein, Alexey V Melnik, Simone M Mantovani, Emily A Monroe, Marcus Moore, Nathan Moss, Hans-Wilhelm Nützmann, Guohui Pan, Amrita Pati, Daniel Petras, F Jerry Reen, Federico Rosconi, Zhe Rui, Zhenhua Tian, Nicholas J Tobias, Yuta Tsunematsu, Philipp Wiemann, Elizabeth Wyckoff, Xiaohui Yan, Grace Yim, Fengan Yu, Yunchang Xie, Bertrand Aigle, Alexander K Apel, Carl J Balibar, Emily P Balskus, Francisco Barona-Gómez, Andreas Bechthold, Helge B Bode, Rainer Borriss, Sean F Brady, Axel A Brakhage, Png Cheng, Jon Clardy, Russell J Cox, René De Mot, Stefano Donadio, Mohamed S Donia, Wilfred A van der Donk, Pieter C Dorrestein, Sean Doyle, Arnold J M Driessen, Monika Ehling-Schulz, Karl-Dieter Entian, Michael A Fischbach, Lena Gerwick, William H Gerwick, Harald Gross, Bertolt Gust, Christian Hertweck, Monica Höfte, Susan E Jensen, Jianhua Ju, Leonard Katz, Leonard Kaysser, Jonathan L Klassen, Nancy P Keller, Jan Kormanec, Oscar P Kuipers, Tomohisa Kuzuyama, Nikos C Kyrpides, Hyung-Jin Kwon, Sylvie Lautru, Rob Lavigne, Chia Y Lee, Bai Linquan, Xinyu Liu, Wen Liu, Andriy Luzhetskyy, Taifo Mahmud, Yvonne Mast, Carmen Méndez, Mikko Metsä-Ketelä, Jason Micklefield, Douglas A Mitchell, Bradley S Moore, Leonilde M Moreira, Rolf Müller, Brett A Neilan, Markus Nett, Jens Nielsen, Fergal O'Gara, Hideaki Oikawa, Anne Osbourn, Marcia S Osburne, Bohdan Ostash, Shelley M Payne, Jean-Luc Pernodet, Miroslav Petricek, Jörn Piel, Olivier Ploux, Jos M Raaijmakers, José A Salas, Esther K Schmitt, Barry Scott, Ryan F Seipke, Ben Shen, David H Sherman, Kaarina Sivonen, Michael J Smanski, Margherita Sosio, Evi Stegmann, Roderich D Süssmuth, Kapil Tahlan, Christopher M Thomas, Yi Tang, Andrew W Truman, Muriel Viaud, Jonathan D Walton,Christopher T Walsh, Tilmann Weber, Gilles P van Wezel, Barrie Wilkinson, Joanne M Willey, Wolfgang Wohlleben, Gerard D Wright, Nadine Ziemert, Changsheng Zhang, Sergey B Zotchev, Rainer Breitling, Eriko Takano, Frank Oliver Glöckner
(A1 Refereed original research article in a scientific journal)
Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection (2015)
- Metabolic Engineering
Guo F, Xiang SH, Li LY, Wang B, Rajasarkka J, Grondahl-Yli-Hannuksela K, Ai GM, Metsa-Ketela M, Yang KG
(A1 Refereed original research article in a scientific journal)
Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family (2014)
- FEBS Journal
Thapa K, Oja T, Metsä-Ketelä M
(A1 Refereed original research article in a scientific journal)
Structure-Based Engineering of Angucyclinone 6-Ketoreductases. (2014)
- Chemistry and Biology
Patrikainen, Niiranen, Thapa, Paananen, Tähtinen, Mäntsälä, Niemi, Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation (2013)
- Current Opinion in Chemical Biology
Metsa-Ketela M, Oja T, Taguchi T, Okamoto S, Ichinose K
(A1 Refereed original research article in a scientific journal)
Biosynthetic Conclusions from the Functional Dissection of Oxygenases for Biosynthesis of Actinorhodin and Related Streptomyces Antibiotics (2013)
- Chemistry and Biology
Taguchi T, Yabe M, Odaki H, Shinozaki M, Metsa-Ketela M, Arai T, Okamoto S, Ichinose K
(A1 Refereed original research article in a scientific journal)
Chemoenzymatic Synthesis of Novel C-Ribosylated Naphthoquinones (2013)
- ACS Chemical Biology
Bastian Blauenburg, Terhi Oja, Karel D Klika, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Structural and Functional Analysis of Angucycline C-6 Ketoreductase LanV Involved in Landomycin Biosynthesis (2013)
- Biochemistry
Pasi Paananen, Pekka Patrikainen, Pauli Kallio, Pekka Mäntsälä, Jarmo Niemi, Laila Niiranen, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway (2013)
- Proceedings of the National Academy of Sciences of the United States of America
Terhi Oja, Laila Niiranen, Tatyana Sandalova, Karel D Klika, Jarmo Niemi, Pekka Mäntsälä, Gunter Schneider, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Synthetic Remodeling of the Chartreusin Pathway to Tune Antiproliferative and Antibacterial Activities (2013)
- Journal of the American Chemical Society
Ueberschaar N, Xu ZL, Scherlach K, Metsa-Ketela M, Bretschneider T, Dahse HM, Gorls H, Hertweck C
(A1 Refereed original research article in a scientific journal)
Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE (2013)
- Biochemistry
Kallio P, Patrikainen P, Belogurov GA, Mantsala P, Yang KQ, Niemi J, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Alnumycins A2 and A3: new inverse-epimeric pairs stereoisomeric to alnumycin A1 (2012)
- Tetrahedron: Asymmetry
Oja T, Tahtinen P, Dreiack N, Mantsala P, Niemi J, Metsa-Ketela M, Klika KD
(A1 Refereed original research article in a scientific journal)
Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage (2012)
- Proceedings of the National Academy of Sciences of the United States of America
Oja T, Klika KD, Appassamy L, Sinkkonen J, Mäntsälä P, Niemi J, Metsä-Ketelä M
(A1 Refereed original research article in a scientific journal)
Characterization of the Two-Component Monooxygenase System AlnT/AlnH Reveals Early Timing of Quinone Formation in Alnumycin Biosynthesis (2012)
- Journal of Bacteriology
Grocholski T, Oja T, Humphrey L, Mäntsälä P, Niemi J, Metsä-Ketelä M
(A1 Refereed original research article in a scientific journal)
Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater (2012)
- FEBS Journal
Claesson M, Siitonen V, Dobritzsch D, Metsa-Ketela M, Schneider G
(A1 Refereed original research article in a scientific journal)