Jarmo Niemi
Ph.D.
jarnie@utu.fi +358 29 450 4701 +358 50 470 4758 Tykistökatu 6 Turku : B6130 |
Antibiotic biosynthesis; biology of Streptomyces; protein research
I was born in Pori, Finland in 1958, graduated from the University of Turku in 1983, got my Ph.D degree in 1998, and was appointed to my present position as lecturer in 2005.
I am married and have two children.
I started work with antibiotic biosynthesis in 1985, when I worked
for the Finnish pharmaceutical company Leiras, and have continued it
since, except for 1995-1998, when I worked in a project concerning
high-throughput screening methods for peptide receptor agonists.
My Ph. D. thesis in 1995 was about "Hybrid
Anthracycline Antibiotics: Analysis and
Application
of Rhodomycin Biosynthetic Genes from Streptomyces purpurascens".
My
research has concerned the biosynthesis of antibiotics by Streptomyces,
its molecular biology, enzymology and structural biology. I continue to
participate in the research of the "Antibiotic biosynthesis
engineering" group http://abelab.utu.fi/
I teach several initial level Biochemistry courses at the University of Turku; BKEM5030 Cell and Biomolecules - Theory, BKEM5010 Microbiology - Theory, BKEM5011 Microbiology - Practice and part of BKEM5160 Cell and Energy - Theory and BKEM5161 Cell and Energy - Practice.
I also teach the course BJ01A1060 Basic Biochemistry at the Lappeenranta University of Technology.
2 of 3
- Crystal Structure of the Cofactor-Independent Monooxygenase SnoaB from Streptomyces nogalater: Implications for the Reaction Mechanism (2010)
- Biochemistry
- Formation and hydrolysis of amide bonds by lipase A from Candida antarctica; exceptional features (2010)
- Organic and Biomolecular Chemistry
- Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway (2009)
- Acta Crystallographica Section F: Structural Biology and Crystallization Communications
- Structural Basis for Substrate Recognition and Specificity in Aklavinone-11-Hydroxylase from Rhodomycin Biosynthesis (2009)
- Journal of Molecular Biology
- A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation (2008) Kallio P, Liu ZL, Mantsala P, Niemi J, Metsa-Ketela M
- Anthracycline biosynthesis: Genes, enzymes and mechanisms (2008)
- Topics in Current Chemistry
- Biosynthetic anthracycline variants (2008)
- Topics in Current Chemistry
- Characterization of the Alnumycin Gene Cluster Reveals Unusual Gene Products for Pyran Ring Formation and Dioxan Biosynthesis (2008)
- Chemistry and Biology
- Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: Chemoenzymatic synthesis of gaudimycin C (2008)
- Chemistry and Biology
- Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site (2007) Alexeev I, Sultana A, Mantsala P, Niemi J, Schneider G
- Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis (2007) Koskiniemi H, Metsa-Ketela M, Dobritzsch D, Kallio P, Korhonen H, Mantsala P, Schneider G, Niemi J
- Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis (2007)
- Journal of Molecular Biology
- Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning (2007)
- Acta Crystallographica Section D: Biological Crystallography
- Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: Implications for catalytic mechanism and product stereoselectivity (2006) Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G
- Crystal structures of SnoaL2 and AcIR: Two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics (2006) Beinker P, Lohkamp B, Peltonen T, Niemi J, Mantsala P, Schneider G
- Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor (2005)
- Journal of Biological Chemistry
- Structural genomics of the biosynthesis of polyketide antibiotics (2005)
- FEBS Journal
- Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis (2004)
- Acta Crystallographica Section D: Biological Crystallography
- Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products (2004)
- Journal of Biological Chemistry
- Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation (2004)
- EMBO Journal
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