Jarmo Niemi
Ph.D.
jarnie@utu.fi +358 29 450 4701 +358 50 470 4758 Tykistökatu 6 Turku : B6130 |
Antibiotic biosynthesis; biology of Streptomyces; protein research
I started work with antibiotic biosynthesis in 1985, when I worked
for the Finnish pharmaceutical company Leiras, and have continued it
since, except for 1995-1998, when I worked in a project concerning
high-throughput screening methods for peptide receptor agonists.
My Ph. D. thesis in 1995 was about "Hybrid
Anthracycline Antibiotics: Analysis and
Application
of Rhodomycin Biosynthetic Genes from Streptomyces purpurascens".
My
research has concerned the biosynthesis of antibiotics by Streptomyces,
its molecular biology, enzymology and structural biology. I continue to
participate in the research of the "Antibiotic biosynthesis
engineering" group http://abelab.utu.fi/
I teach several initial level Biochemistry courses at the University of Turku; BKEM5030 Cell and Biomolecules - Theory, BKEM5010 Microbiology - Theory, BKEM5011 Microbiology - Practice and part of BKEM5160 Cell and Energy - Theory and BKEM5161 Cell and Energy - Practice.
I also teach the course BJ01A1060 Basic Biochemistry at the Lappeenranta University of Technology.
- Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones (2024)
- ACS Synthetic Biology
- Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway (2023)
- ACS Chemical Biology
- Differential regulation of undecylprodigiosin biosynthesis in the yeast-scavenging Streptomyces strain MBK6 (2021)
- FEMS Microbiology Letters
- Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
- Scientific Reports
- Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases (2019)
- ACS Chemical Biology
- Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics (2017)
- ACS Chemical Biology
- Divergent evolution of an atypical S-adenosyl-L-methionine-dependent monooxygenase involved in anthracycline biosynthesis (2015)
- Proceedings of the National Academy of Sciences of the United States of America
- Coordinate changes in gene expression and triacylglycerol composition in the developing seeds of oilseed rape (Brassica napus) and turnip rape (Brassica rapa) (2014)
- Food Chemistry
- Structure-Based Engineering of Angucyclinone 6-Ketoreductases. (2014)
- Chemistry and Biology
- Expression of genes encoding enzymes in the triacylglycerol biosynthesis pathway in developing oilseed rape (Brassica napus) and turnip rape (Brassica rapa) seeds (2013) EuroFoodChem XVII Anssi L. Vuorinen, Marika Kalpio, Maaria Kortesniemi, Kaisa Linderborg, Baoru Yang, Kirsi Lehto, Jarmo Niemi, Heikki P. Kallio
- Structural and Functional Analysis of Angucycline C-6 Ketoreductase LanV Involved in Landomycin Biosynthesis (2013)
- Biochemistry
- Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway (2013)
- Proceedings of the National Academy of Sciences of the United States of America
- Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE (2013)
- Biochemistry
- Alnumycins A2 and A3: new inverse-epimeric pairs stereoisomeric to alnumycin A1 (2012)
- Tetrahedron: Asymmetry
- Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage (2012)
- Proceedings of the National Academy of Sciences of the United States of America
- Characterization of the Two-Component Monooxygenase System AlnT/AlnH Reveals Early Timing of Quinone Formation in Alnumycin Biosynthesis (2012)
- Journal of Bacteriology
- Epimers vs. inverse epimers: the C-1 configuration in alnumycin A1 (2012)
- RSC Advances
- Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities (2012)
- Chemistry and Biology
- The potential of VCD to resolve the epimer vs. inverse epimer quandary (2012)
- Computational and Theoretical Chemistry
- Flavoprotein Hydroxylase PgaE Catalyzes Two Consecutive Oxygen-Dependent Tailoring Reactions in Angucycline Biosynthesis (2011)
- Biochemistry