Jarmo Niemi
Ph.D.
jarnie@utu.fi +358 29 450 4701 +358 50 470 4758 Tykistökatu 6 Turku Office: B6130 ORCID identifier: https://orcid.org/0000-0002-7447-8379 |
Antibiotic biosynthesis; biology of Streptomyces; protein research
I started work with antibiotic biosynthesis in 1985, when I worked
for the Finnish pharmaceutical company Leiras, and have continued it
since, except for 1995-1998, when I worked in a project concerning
high-throughput screening methods for peptide receptor agonists.
My Ph. D. thesis in 1995 was about "Hybrid
Anthracycline Antibiotics: Analysis and
Application
of Rhodomycin Biosynthetic Genes from Streptomyces purpurascens".
My
research has concerned the biosynthesis of antibiotics by Streptomyces,
its molecular biology, enzymology and structural biology. I continue to
participate in the research of the "Antibiotic biosynthesis
engineering" group http://abelab.utu.fi/
I teach several initial level Biochemistry courses at the University of Turku; BKEM5030 Cell and Biomolecules - Theory, BKEM5010 Microbiology - Theory, BKEM5011 Microbiology - Practice and part of BKEM5160 Cell and Energy - Theory and BKEM5161 Cell and Energy - Practice.
I also teach the course BJ01A1060 Basic Biochemistry at the Lappeenranta University of Technology.
- Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA (2026)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones (2024)
- ACS Synthetic Biology
(A1 Refereed original research article in a scientific journal) - Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway (2023)
- ACS Chemical Biology
(A1 Refereed original research article in a scientific journal) - Differential regulation of undecylprodigiosin biosynthesis in the yeast-scavenging Streptomyces strain MBK6 (2021)
- FEMS Microbiology Letters
(A1 Refereed original research article in a scientific journal) - Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases (2019)
- ACS Chemical Biology
(A1 Refereed original research article in a scientific journal) - Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside AntibioticsExpression of genes encoding enzymes in the triacylglycerol biosynthesis pathway in developing oilseed rape (Brassica napus) and turnip rape (Brassica rapa) seeds (2017)
- ACS Chemical Biology
(A1 Refereed original research article in a scientific journal) - Divergent evolution of an atypical S-adenosyl-L-methionine-dependent monooxygenase involved in anthracycline biosynthesis (2015)
- Proceedings of the National Academy of Sciences of the United States of AmericaBiochemistry
(A1 Refereed original research article in a scientific journal) - Coordinate changes in gene expression and triacylglycerol composition in the developing seeds of oilseed rape (Brassica napus) and turnip rape (Brassica rapa)Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway (2014)
- Food ChemistryProceedings of the National Academy of Sciences of the United States of America
(A1 Refereed original research article in a scientific journal) - Structure-Based Engineering of Angucyclinone 6-Ketoreductases. (2014)
- Chemistry and Biology
(A1 Refereed original research article in a scientific journal) - (2013) EuroFoodChem XVII Anssi L. Vuorinen, Marika Kalpio, Maaria Kortesniemi, Kaisa Linderborg, Baoru Yang, Kirsi Lehto, Jarmo Niemi, Heikki P. Kallio
(Other publication) - Structural and Functional Analysis of Angucycline C-6 Ketoreductase LanV Involved in Landomycin BiosynthesisAlnumycins A2 and A3: new inverse-epimeric pairs stereoisomeric to alnumycin A1 (2013)
(A1 Refereed original research article in a scientific journal) - (2013)
(A1 Refereed original research article in a scientific journal) - Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE (2013)
- Biochemistry
(A1 Refereed original research article in a scientific journal) - (2012)
- Tetrahedron: Asymmetry
(A1 Refereed original research article in a scientific journal) - Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavageEpimers vs. inverse epimers: the C-1 configuration in alnumycin A1 (2012)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Refereed original research article in a scientific journal) - Characterization of the Two-Component Monooxygenase System AlnT/AlnH Reveals Early Timing of Quinone Formation in Alnumycin Biosynthesis (2012)
- Journal of Bacteriology
- 2012
- RSC Advances
(A1 Refereed original research article in a scientific journal) - Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic ActivitiesThe potential of VCD to resolve the epimer vs. inverse epimer quandary (2012)
- Chemistry and BiologyComputational and Theoretical Chemistry
(A1 Refereed original research article in a scientific journal) - (2012)
(A1 Refereed original research article in a scientific journal)



