Jarmo Niemi
Ph.D.
jarnie@utu.fi +358 29 450 4701 +358 50 470 4758 Tykistökatu 6 Turku Office: B6130 ORCID identifier: https://orcid.org/0000-0002-7447-8379 |
Antibiotic biosynthesis; biology of Streptomyces; protein research
I started work with antibiotic biosynthesis in 1985, when I worked
for the Finnish pharmaceutical company Leiras, and have continued it
since, except for 1995-1998, when I worked in a project concerning
high-throughput screening methods for peptide receptor agonists.
My Ph. D. thesis in 1995 was about "Hybrid
Anthracycline Antibiotics: Analysis and
Application
of Rhodomycin Biosynthetic Genes from Streptomyces purpurascens".
My
research has concerned the biosynthesis of antibiotics by Streptomyces,
its molecular biology, enzymology and structural biology. I continue to
participate in the research of the "Antibiotic biosynthesis
engineering" group http://abelab.utu.fi/
I teach several initial level Biochemistry courses at the University of Turku; BKEM5030 Cell and Biomolecules - Theory, BKEM5010 Microbiology - Theory, BKEM5011 Microbiology - Practice and part of BKEM5160 Cell and Energy - Theory and BKEM5161 Cell and Energy - Practice.
I also teach the course BJ01A1060 Basic Biochemistry at the Lappeenranta University of Technology.
- Crystal Structure of the Cofactor-Independent Monooxygenase SnoaB from Streptomyces nogalater: Implications for the Reaction Mechanism (2010)
- Biochemistry
(A1 Refereed original research article in a scientific journal) - Formation and hydrolysis of amide bonds by lipase A from Candida antarctica; exceptional features (2010)
- Organic and Biomolecular Chemistry
(A1 Refereed original research article in a scientific journal) - Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway (2009)
- Acta Crystallographica Section F: Structural Biology and Crystallization Communications
(A1 Refereed original research article in a scientific journal) - Structural Basis for Substrate Recognition and Specificity in Aklavinone-11-Hydroxylase from Rhodomycin Biosynthesis (2009)
- Journal of Molecular Biology
(A1 Refereed original research article in a scientific journal) - A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation (2008) Kallio P, Liu ZL, Mantsala P, Niemi J, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal) - Anthracycline biosynthesis: Genes, enzymes and mechanisms (2008)
- Topics in Current Chemistry
(C1 Refereed scientific book) - Biosynthetic anthracycline variants (2008)
- Topics in Current Chemistry
(C1 Refereed scientific book) - Characterization of the Alnumycin Gene Cluster Reveals Unusual Gene Products for Pyran Ring Formation and Dioxan Biosynthesis (2008)
- Chemistry and Biology
(A1 Refereed original research article in a scientific journal) - Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: Chemoenzymatic synthesis of gaudimycin C (2008)
- Chemistry and Biology
(A1 Refereed original research article in a scientific journal) - Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site (2007) Alexeev I, Sultana A, Mantsala P, Niemi J, Schneider G
(A1 Refereed original research article in a scientific journal) - Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis (2007) Koskiniemi H, Metsa-Ketela M, Dobritzsch D, Kallio P, Korhonen H, Mantsala P, Schneider G, Niemi J
(A1 Refereed original research article in a scientific journal) - Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis (2007)
- Journal of Molecular Biology
(A1 Refereed original research article in a scientific journal) - Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning (2007)
- Acta Crystallographica Section D: Biological Crystallography
(A1 Refereed original research article in a scientific journal) - Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: Implications for catalytic mechanism and product stereoselectivity (2006) Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G
(A1 Refereed original research article in a scientific journal) - Crystal structures of SnoaL2 and AcIR: Two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics (2006) Beinker P, Lohkamp B, Peltonen T, Niemi J, Mantsala P, Schneider G
(A1 Refereed original research article in a scientific journal) - Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor (2005)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Structural genomics of the biosynthesis of polyketide antibiotics (2005)
- FEBS Journal
(A1 Refereed original research article in a scientific journal) - Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis (2004)
- Acta Crystallographica Section D: Biological Crystallography
(A1 Refereed original research article in a scientific journal) - Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products (2004)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation (2004)
- EMBO Journal
(A1 Refereed original research article in a scientific journal)



