Harry Scheinin
MD
Anesthesiology and Intensive Care harry.scheinin@utu.fi |
Anesthesiology; Clinical Pharmacology; Neuroscience; Positron Emission Tomography
Harry Scheinin leads the Anesthesia Mechanisms Research Group at the University of Turku, Finland, and has studied the human neurobiology of anesthetic agents for 20 years. He has collaborated with Professor Antti Revonsuo since 2005.
We try to explore the neural correlates of human consciousness using, e.g., modern imaging methods. We aim to separate consciousness from responsiveness, connectedness from disconnection and to compare unconsciousness of physiological sleep with that induced by anesthetic agents. Finding new tools for the distinction of consciousness, connectedness and responsiveness would be groundbreaking and could represent a major leap forward in understanding human consciousness. The results could also help in developing new EEG-based methods to objectively measure consciousness and the depth of general anesthesia.
- Neuroprotective Effects of Inhaled Xenon Gas on Brain Structural Gray Matter Changes After Out-of-Hospital Cardiac Arrest Evaluated by Morphometric Analysis: A Substudy of the Randomized Xe-Hypotheca Trial (2025)
- Neurocritical CareNeuroradiology
- A metabolic profile of xenon and metabolite associations with 6-month mortality after out-of-hospital cardiac arrest : A post-hoc study of the randomised Xe-Hypotheca trial (2024)
- PLoS ONEJournal of Neuroscience
- Tendon graft through the coracoid tunnel versus under the coracoid for coracoclavicular/acromioclavicular reconstruction shows no difference in radiographic or patient-reported outcomesEffects of dexmedetomidine on pharyngeal swallowing and esophageal motility-A double-blind randomized cross-over study in healthy volunteersEffect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial (2024)
- Archives of Orthopaedic and Trauma SurgeryNeurogastroenterology and Motility
- The relationship of bispectral index values to conscious state: an analysis of two volunteer cohort studiesResponse to Letter to the Editor (2024)
- British Journal of Anaesthesia
- Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trialSubjective experiences during dexmedetomidine- or propofol-induced unresponsiveness and non-rapid eye movement sleep in healthy male subjects (2023)
- Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine (2023)
- 2023
- (2023)
- Neurogastroenterology and Motility
- (2023)
- British Journal of Anaesthesia
- Circulating oxylipin and bile acid profiles of dexmedetomidine, propofol, sevoflurane, and S-ketamine : a randomised controlled trial using tandem mass spectrometry (2022)
- BJA Open
- Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome: A randomised trial using nuclear magnetic resonance spectroscopy (2022)
- European Journal of AnaesthesiologyConsciousness and Cognition
- Anestesiologian ja tehohoidon kliinisen tutkimuksen perusteita (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry, Uusaro Ari
- (2021)
- Critical Care Explorations
- Foundations of human consciousness: Imaging the twilight zone (2021)
- Journal of Neuroscience
- Inhalaatioanestesia ja laskimoanestesia (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry
- Laskimoanestesia-aineet ja sedaatiolääkkeet (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry, Valtonen Mika
- On no man’s land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents (2021)
- Seasonal variation in the brain μ-opioid receptor availability (2021)
- Journal of Neuroscience
- Aivojen vapaiden myy-opioidireseptorien määrä vaihtelee ihmisten välillä (2020)
- Duodecim
- Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol (2020)
- British Journal of Anaesthesia



