Harry Scheinin
MD
Anesthesiology and Intensive Care harry.scheinin@utu.fi ORCID identifier: https://orcid.org/0000-0002-1171-3511 |
Anesthesiology; Clinical Pharmacology; Neuroscience; Positron Emission Tomography
Harry Scheinin leads the Anesthesia Mechanisms Research Group at the University of Turku, Finland, and has studied the human neurobiology of anesthetic agents for 20 years. He has collaborated with Professor Antti Revonsuo since 2005.
We try to explore the neural correlates of human consciousness using, e.g., modern imaging methods. We aim to separate consciousness from responsiveness, connectedness from disconnection and to compare unconsciousness of physiological sleep with that induced by anesthetic agents. Finding new tools for the distinction of consciousness, connectedness and responsiveness would be groundbreaking and could represent a major leap forward in understanding human consciousness. The results could also help in developing new EEG-based methods to objectively measure consciousness and the depth of general anesthesia.
- Neuroprotective Effects of Inhaled Xenon Gas on Brain Structural Gray Matter Changes After Out-of-Hospital Cardiac Arrest Evaluated by Morphometric Analysis: A Substudy of the Randomized Xe-Hypotheca Trial (2025)
- Neurocritical Care
(A1 Refereed original research article in a scientific journal) - A metabolic profile of xenon and metabolite associations with 6-month mortality after out-of-hospital cardiac arrest : A post-hoc study of the randomised Xe-Hypotheca trial (2024)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Tendon graft through the coracoid tunnel versus under the coracoid for coracoclavicular/acromioclavicular reconstruction shows no difference in radiographic or patient-reported outcomes (2024)
- Archives of Orthopaedic and Trauma Surgery
(A1 Refereed original research article in a scientific journal) - The relationship of bispectral index values to conscious state: an analysis of two volunteer cohort studies (2024)
- British Journal of Anaesthesia
(A1 Refereed original research article in a scientific journal) - Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial (2023)
- Neuroradiology
(A1 Refereed original research article in a scientific journal) - Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine (2023)
- Journal of Neuroscience
(A1 Refereed original research article in a scientific journal) - Effects of dexmedetomidine on pharyngeal swallowing and esophageal motility-A double-blind randomized cross-over study in healthy volunteers (2023)
- Neurogastroenterology and Motility
(A1 Refereed original research article in a scientific journal) - Response to Letter to the Editor (2023)
- Neurogastroenterology and Motility
(B1 Non-refereed article in a scientific journal) - Subjective experiences during dexmedetomidine- or propofol-induced unresponsiveness and non-rapid eye movement sleep in healthy male subjects (2023)
- British Journal of Anaesthesia
(A1 Refereed original research article in a scientific journal) - Circulating oxylipin and bile acid profiles of dexmedetomidine, propofol, sevoflurane, and S-ketamine : a randomised controlled trial using tandem mass spectrometry (2022)
- BJA Open
(A1 Refereed original research article in a scientific journal) - Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome: A randomised trial using nuclear magnetic resonance spectroscopy (2022)
- European Journal of Anaesthesiology
(A1 Refereed original research article in a scientific journal) - Anestesiologian ja tehohoidon kliinisen tutkimuksen perusteita (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry, Uusaro Ari
(D2 Article in a professional compilation book) - Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial (2021)
- Critical Care Explorations
(A1 Refereed original research article in a scientific journal) - Foundations of human consciousness: Imaging the twilight zone (2021)
- Journal of Neuroscience
(A1 Refereed original research article in a scientific journal) - Inhalaatioanestesia ja laskimoanestesia (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry
(D2 Article in a professional compilation book) - Laskimoanestesia-aineet ja sedaatiolääkkeet (2021) Anestesiologia, teho-, ensi- ja kivunhoito Scheinin Harry, Valtonen Mika
(D2 Article in a professional compilation book) - On no man’s land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents (2021)
- Consciousness and Cognition
(A1 Refereed original research article in a scientific journal) - Seasonal variation in the brain μ-opioid receptor availability (2021)
- Journal of Neuroscience
(A1 Refereed original research article in a scientific journal) - Aivojen vapaiden myy-opioidireseptorien määrä vaihtelee ihmisten välillä (2020)
- Duodecim
(D1 Article in a professional journal) - Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol (2020)
- British Journal of Anaesthesia
(A1 Refereed original research article in a scientific journal)