PhD, Docent Gennadi Egutkin - UTU Research Portal

Gennadi Egutkin
PhD, Docent

- Docent,
Institute of Biomedicine (Faculty of Medicine)
- Senior Research Fellow,
MediCity (Faculty of Medicine)

genyeg@utu.fi

+358 29 450 4388

Tykistökatu 6

Turku

: https://orcid.org/0000-0001-6684-7982

Yegutkin_CV_2025.pdf

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Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks (2018)
- BBA - Molecular Basis of Disease
Karolina Losenkova, Mariachiara Zuccarini, Mikko Helenius, Guillaume Jacquemet, Evgenia Gerasimovskaya, Camilla Tallgren, Sirpa Jalkanen, Gennady G. Yegutkin
Regulation of intratumoral purine homeostasis and signaling via concerted action of alkaline phosphatases, CD39 and CD73 (2018)
- Purinergic Signalling
Losenkova K, Zeiner J, Kukkonen-Macchi A, Algars A, Sundstrom J, Jalkanen S, Yegutkin GG
Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy (2017)
- Journal of Molecular Medicine
Sirpa Loukovaara, Jouko Sandholm, Kristiina Aalto, Janne Liukkonen, Sirpa Jalkanen, Gennady G. Yegutkin
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent (2017)
- Nature Communications
Song AR, Zhang YJ, Han L, Yegutkin GG, Liu H, Sun KQ, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng TT, Zhao SS, Wang W, Wu HY, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin JP, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y, Xia Y
Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities (2016)
- Trends in Cancer
Luca Antonioli, Gennady G. Yegutkin, Pál Pacher, Corrado Blandizzi, György Haskó
Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia (2016)
- Circulation
Liu H, Zhang YJ, Wu HY, D'Alessandro A, Yegutkin GG, Song A, Sun KQ, Li J, Cheng NY, Huang AJ, Edward Y, Weng TT, Luo FY, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Houten SJV, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y
How Intravitreal Ecto-5 nucleotidase/CD73 and Adenylate kinase-1 Contribute to Ocular Nucleotide Homeostasis and Are Modulated in Patients with Diabetic Retinopathy (2016)
- Ophthalmologica
Loukovaara S, Sandholm J, Rantakari P, Liukkonen J, Jalkanen S, Yegutkin G
NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD (2016)
- European Respiratory Journal
Lazar Z, Mullner N, Lucattelli M, Ayata CK, Cicko S, Yegutkin GG, De Cunto G, Muller T, Meyer A, Hossfeld M, Sorichter S, Horvath I, Virchow CJ, Robson SC, Lungarella G, Idzko M
Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions (2016)
- Purinergic Signalling
Yegutkin GG, Guerrero-Toro C, Kilinc E, Koroleva K, Ishchenko Y, Abushik P, Giniatullina R, Fayuk D, Giniatullin R
Simvastatin use associated with low intraocular ADP levels in patients with sight-threatening diabetic retinopathy (2016)
- Graefe's Archive for Clinical and Experimental Ophthalmology
Tuuminen R, Yegutkin GG, Jalkanen S, Loukovaara S
Aberrant Circulating Levels of Purinergic Signaling Markers Are Associated With Several Key Aspects of Peripheral Atherosclerosis and Thrombosis (2015)
- Circulation Research
Jalkanen J, Yegutkin GG, Hollmen M, Aalto K, Kiviniemi T, Salomaa V, Jalkanen S, Hakovirta H
alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5 '-Nucleotidase (CD73) Inhibitors (2015)
- Journal of Medicinal Chemistry
Bhattarai S, Freundlieb M, Pippel J, Meyer A, Abdelrahman A, Fiene A, Lee SY, Zimmermann H, Yegutkin GG, Strater N, El-Tayeb A, Muller CE
ATP release, generation and hydrolysis in exocrine pancreatic duct cells (2015)
- Purinergic Signalling
Kowal JM, Yegutkin GG, Novak I
Ecto-5'-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature (2015)
- European Journal of Immunology
Gennady G. Yegutkin, Kaisa Auvinen, Pia Rantakari, Maija Hollmén, Marika Karikoski, Reidar Grénman, Kati Elima, Sirpa Jalkanen, Marko Salmi
Increased intravitreal adenosine 5′-triphosphate, adenosine 5′-diphosphate and adenosine 5′-monophosphate levels in patients with proliferative diabetic retinopathy (2015)
- Acta Ophthalmologica
Sirpa Loukovaara, Sari Sahanne, Sirpa Jalkanen, Gennady G. Yegutkin
MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice (2015)
- Allergy
Zech A, Ayata CK, Pankratz F, Meyer A, Baudiss K, Cicko S, Yegutkin GG, Grundmann S, Idzko M
Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate (2015)
- PLoS ONE
Elovaara H, Huusko T, Maksimow M, Elima K, Yegutkin GG, Skurnik M, Dobrindt U, Siitonen A, McPherson MJ, Salmi M, Jalkanen S
Toll like receptor-9 and CD73 may act on the same pathway to induce immunosuppression in triple negative breast cancer cells (2015)
- Cancer Research
Selander KS, Tuomela JM, Mella M, Kauppila J, Sandholm J, Yegutkin G, Karihtala P, Jukkola-Vuorinen A, Haapasaari KM, Vuopala KS, Harris KW
Adenosine activates brown adipose tissue and recruits beige adipocytes via A(2A) receptors (2014)
- Nature
Thorsten Gnad, Saskia Scheibler, Ivar von Kügelgen, Camilla Scheele, Ana Kilić, Anja Glöde, Linda S. Hoffmann, Laia Reverte-Salisa, Philipp Horn, Samet Mutlu, Ali El-Tayeb, Mathias Kranz, Winnie Deuther-Conrad, Peter Brust, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Schrader, Gennady G. Yegutkin, Christa E. Müller, Alexander Pfeifer
Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms. (2014)
- Molecular Cancer Research
Virtanen SS, Kukkonen-Macchi A, Vainio M, Elima K, Härkönen PL, Jalkanen S, Yegutkin GG