PhD, Docent Gennadi Egutkin - UTU Research Portal

Gennadi Egutkin
PhD, Docent

- Docent,
Institute of Biomedicine (Faculty of Medicine)
- Senior Research Fellow,
MediCity (Faculty of Medicine)

genyeg@utu.fi

+358 29 450 4388

Tykistökatu 6

Turku

ORCID identifier: https://orcid.org/0000-0001-6684-7982

Yegutkin_CV_2025.pdf

Publications

1 of 3

Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance (2025)
- Cell Reports
Lehtonen, Henna; Jokela, Heli; Hofmann, Julian; Tola, Lauriina; Mehmood, Arfa; Ginhoux, Florent; Becher, Burkhard; Greter, Melanie; Yegutkin, Gennady G.; Salmi, Marko; Gerke, Heidi; Rantakari, Pia
(A1 Refereed original research article in a scientific journal)
Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain (2025)
- Molecular Medicine
Pomeroy, Joanna; Borczyk, Malgorzata; Kawalec, Maria; Hajto, Jacek; Carlson, Emma; Svärd, Samuel; Verma, Suraj; Bareke, Eric; Boratyńska-Jasińska, Anna; Dymkowska, Dorota; Mellado-Ibáñez, Alvaro; Laight, David; Zabłocki, Krzysztof; Occhipinti, Annalisa; Majewska, Loydie; Angione, Claudio; Majewski, Jacek; Yegutkin, Gennady G.; Korostynski, Michal; Zabłocka, Barbara; Górecki, Dariusz C.
(A1 Refereed original research article in a scientific journal)
Isolation of vasa vasorum endothelial cells from pulmonary artery adventitia: Implementation to vascular biology research (2023)
- Microvascular Research
Burns Nana, Nijmeh Hala, Lapel Martin, Riddle Suzette, Yegutkin Gennadi G, Stenmark Kurt R, Gerasimovskaya Evgenia
(A1 Refereed original research article in a scientific journal)
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain (2022)
- Pharmacological Reviews
Yegutkin Gennady G, Boison Detlev
(A2 Refereed review article in a scientific journal )
CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity (2022)
- Cellular and Molecular Life Sciences
Losenkova Karolina, Takeda Akira, Ragauskas Symantas, Cerrada-Gimenez Marc, Vähätupa Maria, Kaja Simon, Paul Marius L., Schmies Constanze C., Rolshoven Georg, Müller Christa E., Sandholm Jouko, Jalkanen Sirpa, Kalesnykas Giedrius, Yegutkin Gennady G.
(A1 Refereed original research article in a scientific journal)
Structure-Activity Relationship of 3-Methylcytidine-5 '-alpha,beta-methylenediphosphates as CD73 Inhibitors (2022)
- Journal of Medicinal Chemistry
Scortichini Mirko, Idris Riham Mohammed, Moschutz Susanne, Keim Antje, Salmaso Veronica, Dobelmann Clemens, Oliva Paola, Losenkova Karolina, Irjala Heikki, Vaittinen Samuli, Sandholm Jouko, Yegutkin Gennady G, Sträter Norbert, Junker Anna, Müller Christa E, Jacobson Kenneth A
(A1 Refereed original research article in a scientific journal)
Structure activity relationship of 3-methylcytidine-5'-α,β-methylenediphosphates as CD73 inhibitors (2022)
- FASEB Journal
EB 2022 Jacobson Kenneth A., Scortichini Mirko, Idris Riham M., Moschütz Suzanne, Keim Antje, Salmaso Veronica A., Dobelmann Clemens, Oliva Paola A., Losenkova Karolina, Irjala Heikki, Vaittinen Samuli, Sandholm Jouko, Yegutkin Gennady G., Sträter Norbert, Junker Anna, Müller Christa E.
(Other publication)
Adenosine metabolism in the vascular system (2021)
- Biochemical Pharmacology
Yegutkin Gennady G.
(A2 Refereed review article in a scientific journal )
CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer (2021)
- Scientific Reports
Petruk Nataliia, Tuominen Sanni, Åkerfelt Malin, Mattsson Jesse, Sandholm Jouko, Nees Matthias, Yegutkin Gennady G., Jukkola Arja, Tuomela Johanna, Selander Katri S.
(A1 Refereed original research article in a scientific journal)
Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes (2021)
- Frontiers in Immunology
Kobayashi Daichi, Sugiura Yuki, Umemoto Eiji, Takeda Akira, Ueta Hisashi, Hayasaka Haruko, Matsuzaki Shinsuke, Katakai Tomoya, Suematsu Makoto, Hamachi Itaru, Yegutkin Gennady G, Salmi Marko, Jalkanen Sirpa, Miyasaka Masayuki
(A1 Refereed original research article in a scientific journal)
Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia (2020)
- Journal of Cell Science
Losenkova K, Zuccarini M, Karikoski M, Laurila J, Boison D, Jalkanen S, Yegutkin GG
(A1 Refereed original research article in a scientific journal)
Fluorescent Probes for Ecto-5 '-nucleotidase (CD73) (2020)
- ACS Medicinal Chemistry Letters
Schmies CC, Rolshoven G, Idris RM, Losenkova K, Renn C, Schakel L, Al-Hroub H, Wang YL, Garofano F, Schmidt-Wolf IGH, Zimmermann H, Yegutkin GG, Muller CE
(A1 Refereed original research article in a scientific journal)
Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism (2020)
- mAbs
Spatola BN, Lerner AG, Wong C, dela Cruz T, Welch M, Fung WC, Kovalenko M, Losenkova K, Yegutkin GG, Beers C, Corbin J, Soros VB
(A1 Refereed original research article in a scientific journal)
Histochemical approach for simultaneous detection of ectonucleotidase and alkaline phosphatase activities in tissues (2020) Purinergic Signaling Karolina Losenkova, Marius Paul, Heikki Irjala, Sirpa Jalkanen, Gennady G. Yegutkin
(A3 Refereed book chapter or chapter in a compilation book)
Adenosine Metabolism: Emerging Concepts for Cancer Therapy (2019)
- Cancer Cell
Detlev Boison, Gennady Yegutkin
(A2 Refereed review article in a scientific journal )
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)
- Journal of Molecular Medicine
Julian Zeiner, Sirpa Loukovaara, Karolina Losenkova, Mariachiare Zuccarini, Ani M. Korhonen, Kaisa Lehti, Anu Kauppinen, Kai Kaarniranta, Christa E. Muller, Sirpa Jalkanen, Gennady G. Yegutkin
(A1 Refereed original research article in a scientific journal)
Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5 '-Nucleotidase (CD73) Inhibitors (2019)
- Journal of Medicinal Chemistry
Junker A., Renn C., Dobelmann C., Namasivayam V., Jain S., Losenkova K., Irjala H., Duca S., Balasubramanian R., Chakraborty S., Börgel F., Zimmermann H., Yegutkin G.G., Müller C.E., Jacobson K.A.
(A1 Refereed original research article in a scientific journal)
Targeting CD39 with a first-in-class inhibitory antibody prevents ATP processing and increases T-cell activation (2019)
- Cancer Research
Lerner AG, Kovalenko M, Welch M, Dela Cruz T, Jones J, Wong C, Spatola B, Eberhardt M, Wong A, Fung W, Lagpacan L, Losenkova K, Yegutkin G, Soros V, Corbin J, Beers C, Moesta AK, Moesta AK
(Other publication)
X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 '-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy (2019)
- Advanced therapeutics
Sanjay Bhattarai, Jan Pippel, Anne Meyer, Marianne Freundlieb, Constanze Schmies, Aliaa Abdelrahman, Amelie Fiene, Sang-Yong Lee, Herbert Zimmermann, Ali El-Tayeb, Gennady G. Yegutkin, Norbert Sträter, Christa E. Muller
(A1 Refereed original research article in a scientific journal)
Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum (2018)
- Journal of Investigative Dermatology
Gilles Kauffenstein, Gennady G. Yegutkin, Salim Khiati, Viola Pomozi, Olivier Le Saux, Georges Leftheriotis, Guy Lenaers, Daniel Henrion, Ludovic Martin
(A1 Refereed original research article in a scientific journal)