Gennadi Egutkin
PhD, Docent
genyeg@utu.fi +358 29 450 4388 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0001-6684-7982 |
My research focus for the past 25 years has been to investigate cellular metabolism in various pathophysiological states. I have especially contributed to the papers dealing with role of purine-converting enzymes in cancer, inflammation and vascular remodelling. Overall, I have >100 publications including six Invited Review Articles and four Book Chapters.
Principal supervisor (PS) or co-supervisor (co-S) for for the following theses: Bachelor’s thesis of Camilla Tallgren (Turku University of Applied Sciences; May 2011, PS) • Master of Science (MSc) thesis of Mikko Helenius (UTU; March 2011, PS) • PhD thesis of Mariachiara Zuccarini (University of Chieti-Pescara, Italy; April 2015, PS) • PhD thesis of Mikko Helenius (University of Helsinki; October 2015, co-S) • MSc thesis of Marius Paul (University of Bonn [UB], Germany; May 2019, PS) • MSc thesis of Nora Kreisig (UB, September 2024, PS) • MSc thesis of Samuel Svärd (UTU; November 2024, PS) • PhD thesis of Karolina Losenkova (UTU; March 2025, PS) • MSc thesis of Julia Baier (UB, April 2026, PS). Currently, I am supervising PhD Theses of Samuel Svärd (UTU, PS), and Shaghayegh Hasanpour (UTU, co-S), and MSc theses of Ursula von Danwitz (UB, PS).
The following visiting researchers, undergraduate and PhD students received training in MediCity under my supervision: Dr. Nathalie Mercier (Nancy, France; 2008–2010) • Anne Meyer (UB, April–June 2014) • Justyna Kowal (University of Copenhagen, Denmark, December 2014) • Mariachiara Zuccarini (University of Chieti-Pescara, Italy, September 2014 – February 2015) • Valeria Quarona (University of Torino, Italy, April 2015) • Octavia Cadassou (University of Lyon, France, January – February 2017) • Karolina Losenkova (Moscow Institute of Physics, Russia, October 2015 – November 2017) • Julian Zeiner (UB, May – October 2017) • Marius Paul (UB, January – May 2018) • Corinna Weiler (UB, May – October 2021) • Nora Kreisig (UB, May – October 2023) • Joanna Pomeroy (University of Portsmouth, UK, July 2024) • Ursula Johanna von Danwitz (UB, May – October 2025) • Julia Baier (UB, July 2025 – February 2026).
- Extracellular ATP and adaptive immunity (2026) ATP: From Neurotransmission to Cancer Therapy Junger, Wolfgang G.; Yegutkin, Gennady G.
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors (2026)
- Angewandte Chemie International Edition
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Methodological guidelines for P2X receptor assays and data interpretation (2026)
- Cell Death and Disease
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Release of ATP into the extracellular space (2026) ATP: From Neurotransmission to Cancer Therapy Yegutkin, Gennady G.; Junger, Wolfgang G.
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance (2025)
- Cell Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain (2025)
- Molecular Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Isolation of vasa vasorum endothelial cells from pulmonary artery adventitia: Implementation to vascular biology research (2023)
- Microvascular Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain (2022)
- Pharmacological Reviews
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity (2022)
- Cellular and Molecular Life Sciences
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Structure-Activity Relationship of 3-Methylcytidine-5 '-alpha,beta-methylenediphosphates as CD73 Inhibitors (2022)
- Journal of Medicinal Chemistry
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Structure activity relationship of 3-methylcytidine-5'-α,β-methylenediphosphates as CD73 inhibitors (2022)
- FASEB Journal
(O2 Muu julkaisu ) - Adenosine metabolism in the vascular system (2021)
- Biochemical Pharmacology
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer (2021)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes (2021)
- Frontiers in immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia (2020)
- Journal of Cell Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Fluorescent Probes for Ecto-5 '-nucleotidase (CD73) (2020)
- ACS Medicinal Chemistry Letters
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism (2020)
- mAbs
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Histochemical approach for simultaneous detection of ectonucleotidase and alkaline phosphatase activities in tissues (2020) Purinergic Signaling Karolina Losenkova, Marius Paul, Heikki Irjala, Sirpa Jalkanen, Gennady G. Yegutkin
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Adenosine Metabolism: Emerging Concepts for Cancer Therapy (2019)
- Cancer Cell
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)
- Journal of Molecular Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )



