Gennadi Egutkin
PhD, Docent
genyeg@utu.fi +358 29 450 4388 Tykistökatu 6 Turku |
My research focus for the past 25 years has been to investigate cellular metabolism in various pathophysiological states. I have especially contributed to the papers dealing with role of purine-converting enzymes in cancer, inflammation and vascular remodelling. Overall, I have >100 publications including six Invited Review Articles and four Book Chapters.
Principal supervisor (PS) or co-supervisor (co-S) for for the following theses: Bachelor’s thesis of Camilla Tallgren (Turku University of Applied Sciences; May 2011, PS) • Master of Science (MSc) thesis of Mikko Helenius (UTU; March 2011, PS) • PhD thesis of Mariachiara Zuccarini (University of Chieti-Pescara, Italy; April 2015, PS) • PhD thesis of Mikko Helenius (University of Helsinki; October 2015, co-S) • MSc thesis of Marius Paul (University of Bonn [UB], Germany; May 2019, PS) • MSc thesis of Nora Kreisig (UB, September 2024, PS) • MSc thesis of Samuel Svärd (UTU; November 2024, PS) • PhD thesis of Karolina Losenkova (UTU; March 2025, PS) • MSc thesis of Julia Baier (UB, April 2026, PS). Currently, I am supervising PhD Theses of Samuel Svärd (UTU, PS), and Shaghayegh Hasanpour (UTU, co-S), and MSc theses of Ursula von Danwitz (UB, PS).
The following visiting researchers, undergraduate and PhD students received training in MediCity under my supervision: Dr. Nathalie Mercier (Nancy, France; 2008–2010) • Anne Meyer (UB, April–June 2014) • Justyna Kowal (University of Copenhagen, Denmark, December 2014) • Mariachiara Zuccarini (University of Chieti-Pescara, Italy, September 2014 – February 2015) • Valeria Quarona (University of Torino, Italy, April 2015) • Octavia Cadassou (University of Lyon, France, January – February 2017) • Karolina Losenkova (Moscow Institute of Physics, Russia, October 2015 – November 2017) • Julian Zeiner (UB, May – October 2017) • Marius Paul (UB, January – May 2018) • Corinna Weiler (UB, May – October 2021) • Nora Kreisig (UB, May – October 2023) • Joanna Pomeroy (University of Portsmouth, UK, July 2024) • Ursula Johanna von Danwitz (UB, May – October 2025) • Julia Baier (UB, July 2025 – February 2026).
- Extracellular ATP and adaptive immunity (2026) ATP: From Neurotransmission to Cancer Therapy Junger, Wolfgang G.; Yegutkin, Gennady G.
- (2026)
- Angewandte Chemie International Edition
- Methodological guidelines for P2X receptor assays and data interpretationATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain (2026)
- Cell Death and DiseaseCell Reports
- Release of ATP into the extracellular space (2026) ATP: From Neurotransmission to Cancer Therapy Yegutkin, Gennady G.; Junger, Wolfgang G.
- Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance (2025)
- Structure activity relationship of 3-methylcytidine-5'-α,β-methylenediphosphates as CD73 inhibitors (2025)
- Molecular Medicine
- Isolation of vasa vasorum endothelial cells from pulmonary artery adventitia: Implementation to vascular biology researchAdenosine metabolism in the vascular system (2023)
- Microvascular Research
- 2022
- Pharmacological Reviews
- CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicityExtracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes (2022)
- Cellular and Molecular Life SciencesFrontiers in immunology
- Structure-Activity Relationship of 3-Methylcytidine-5 '-alpha,beta-methylenediphosphates as CD73 InhibitorsCompartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia (2022)
- Journal of Medicinal ChemistryJournal of Cell Science
- (2022)
- FASEB JournalACS Medicinal Chemistry Letters
- (2021)
- Biochemical Pharmacology
- CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer (2021)
- Scientific Reports
- (2021)
- (2020)
- Fluorescent Probes for Ecto-5 '-nucleotidase (CD73) (2020)
- Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism (2020)
- mAbs
- Histochemical approach for simultaneous detection of ectonucleotidase and alkaline phosphatase activities in tissues (2020) Purinergic Signaling Karolina Losenkova, Marius Paul, Heikki Irjala, Sirpa Jalkanen, Gennady G. Yegutkin
- Adenosine Metabolism: Emerging Concepts for Cancer Therapy (2019)
- Cancer Cell
- Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)
- Journal of Molecular Medicine



