Gennadi Egutkin
PhD, Docent
- Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance (2025) Lehtonen, Henna; Jokela, Heli; Hofmann, Julian; Tola, Lauriina; Mehmood, Arfa; Ginhoux, Florent; Becher, Burkhard; Greter, Melanie; Yegutkin, Gennady G.; Salmi, Marko; Gerke, Heidi; Rantakari, Pia
- Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain (2025) Pomeroy, Joanna; Borczyk, Malgorzata; Kawalec, Maria; Hajto, Jacek; Carlson, Emma; Svärd, Samuel; Verma, Suraj; Bareke, Eric; Boratyńska-Jasińska, Anna; Dymkowska, Dorota; Mellado-Ibáñez, Alvaro; Laight, David; Zabłocki, Krzysztof; Occhipinti, Annalisa; Majewska, Loydie; Angione, Claudio; Majewski, Jacek; Yegutkin, Gennady G.; Korostynski, Michal; Zabłocka, Barbara; Górecki, Dariusz C.
- Isolation of vasa vasorum endothelial cells from pulmonary artery adventitia: Implementation to vascular biology research (2023) Burns Nana, Nijmeh Hala, Lapel Martin, Riddle Suzette, Yegutkin Gennadi G, Stenmark Kurt R, Gerasimovskaya Evgenia
- ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain (2022) Yegutkin Gennady G, Boison Detlev
- CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity (2022)
- Cellular and Molecular Life Sciences
Losenkova Karolina, Takeda Akira, Ragauskas Symantas, Cerrada-Gimenez Marc, Vähätupa Maria, Kaja Simon, Paul Marius L., Schmies Constanze C., Rolshoven Georg, Müller Christa E., Sandholm Jouko, Jalkanen Sirpa, Kalesnykas Giedrius, Yegutkin Gennady G.
- Structure-Activity Relationship of 3-Methylcytidine-5 '-alpha,beta-methylenediphosphates as CD73 Inhibitors (2022)
- Journal of Medicinal Chemistry
Scortichini Mirko, Idris Riham Mohammed, Moschutz Susanne, Keim Antje, Salmaso Veronica, Dobelmann Clemens, Oliva Paola, Losenkova Karolina, Irjala Heikki, Vaittinen Samuli, Sandholm Jouko, Yegutkin Gennady G, Sträter Norbert, Junker Anna, Müller Christa E, Jacobson Kenneth A
- Structure activity relationship of 3-methylcytidine-5'-α,β-methylenediphosphates as CD73 inhibitors (2022) EB 2022 Jacobson Kenneth A., Scortichini Mirko, Idris Riham M., Moschütz Suzanne, Keim Antje, Salmaso Veronica A., Dobelmann Clemens, Oliva Paola A., Losenkova Karolina, Irjala Heikki, Vaittinen Samuli, Sandholm Jouko, Yegutkin Gennady G., Sträter Norbert, Junker Anna, Müller Christa E.
- Adenosine metabolism in the vascular system (2021) Yegutkin Gennady G.
- CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer (2021) Petruk Nataliia, Tuominen Sanni, Åkerfelt Malin, Mattsson Jesse, Sandholm Jouko, Nees Matthias, Yegutkin Gennady G., Jukkola Arja, Tuomela Johanna, Selander Katri S.
- Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes (2021) Kobayashi Daichi, Sugiura Yuki, Umemoto Eiji, Takeda Akira, Ueta Hisashi, Hayasaka Haruko, Matsuzaki Shinsuke, Katakai Tomoya, Suematsu Makoto, Hamachi Itaru, Yegutkin Gennady G, Salmi Marko, Jalkanen Sirpa, Miyasaka Masayuki
- Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia (2020) Losenkova K, Zuccarini M, Karikoski M, Laurila J, Boison D, Jalkanen S, Yegutkin GG
- Fluorescent Probes for Ecto-5 '-nucleotidase (CD73) (2020)
- ACS Medicinal Chemistry Letters
Schmies CC, Rolshoven G, Idris RM, Losenkova K, Renn C, Schakel L, Al-Hroub H, Wang YL, Garofano F, Schmidt-Wolf IGH, Zimmermann H, Yegutkin GG, Muller CE
- Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism (2020) Spatola BN, Lerner AG, Wong C, dela Cruz T, Welch M, Fung WC, Kovalenko M, Losenkova K, Yegutkin GG, Beers C, Corbin J, Soros VB
- Histochemical approach for simultaneous detection of ectonucleotidase and alkaline phosphatase activities in tissues (2020) Purinergic Signaling Karolina Losenkova, Marius Paul, Heikki Irjala, Sirpa Jalkanen, Gennady G. Yegutkin
- Adenosine Metabolism: Emerging Concepts for Cancer Therapy (2019) Detlev Boison, Gennady Yegutkin
- Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)
- Journal of Molecular Medicine
Julian Zeiner, Sirpa Loukovaara, Karolina Losenkova, Mariachiare Zuccarini, Ani M. Korhonen, Kaisa Lehti, Anu Kauppinen, Kai Kaarniranta, Christa E. Muller, Sirpa Jalkanen, Gennady G. Yegutkin
- Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5 '-Nucleotidase (CD73) Inhibitors (2019)
- Journal of Medicinal Chemistry
Junker A., Renn C., Dobelmann C., Namasivayam V., Jain S., Losenkova K., Irjala H., Duca S., Balasubramanian R., Chakraborty S., Börgel F., Zimmermann H., Yegutkin G.G., Müller C.E., Jacobson K.A.
- Targeting CD39 with a first-in-class inhibitory antibody prevents ATP processing and increases T-cell activation (2019) Lerner AG, Kovalenko M, Welch M, Dela Cruz T, Jones J, Wong C, Spatola B, Eberhardt M, Wong A, Fung W, Lagpacan L, Losenkova K, Yegutkin G, Soros V, Corbin J, Beers C, Moesta AK, Moesta AK
- X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 '-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy (2019) Sanjay Bhattarai, Jan Pippel, Anne Meyer, Marianne Freundlieb, Constanze Schmies, Aliaa Abdelrahman, Amelie Fiene, Sang-Yong Lee, Herbert Zimmermann, Ali El-Tayeb, Gennady G. Yegutkin, Norbert Sträter, Christa E. Muller
- Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum (2018)
- Journal of Investigative Dermatology
Gilles Kauffenstein, Gennady G. Yegutkin, Salim Khiati, Viola Pomozi, Olivier Le Saux, Georges Leftheriotis, Guy Lenaers, Daniel Henrion, Ludovic Martin
