Eeva-Liisa Eskelinen
PhD
Cell biology, autophagy, lysosomes, RAB24, electron microscopy, cell imaging
1. Biological functions and molecular mechanisms of the small GTPase RAB24. 2. Membrane dynamics in autophagy. Web site: https://sites.utu.fi/eskelinengroup/
Eeva-Liisa Eskelinen has a long track record in autophagy field, in particular, in elucidating the fine structure and membrane dynamics of autophagosome biogenesis using electron microscopy. She completed her PhD in 1993 at the University of Jyväskylä, Finland. After that, she worked as postdoctoral researcher in Göttingen, Germany and Helsinki, Finland. Then she moved to Dundee, Scotland, where she worked as an independent investigator (1999-2002). From Scotland she moved to Kiel, Germany and worked as a group leader at the department headed by professor Paul Saftig (2002-2005). In August 2005 she moved back to Finland and worked as a University Lecturer at the Department of Biosciences, University of Helsinki, until 2017. 1st of November 2017 she started as a Professor of medical cell biology at the Institute of Biomedicine, University of Turku, Finland.
The small GTPase RAB24
We study the biological functions and molecular mechanisms of RAB24, a GTPase that we showed to function in the late phase of the macroautophagic pathway. Mutation in RAB24 causes hereditary ataxia in dogs. In addition, RAB24 was shown to be overexpressed in hepatocellular carcinoma, and the overexpression was further shown to facilitate the malignant phenotype of the cancer cells. RAB24 is also overexpressed in non-alcoholic fatty liver disease. We use cell and molecular biological and biochemical approaches in order to clarify the biological functions of RAB24, as well as the molecular mechanisms that mediate these functions.
Membrane dynamics in autophagy
Autophagy is a lysosomal degradation pathway for cytoplasmic material and organelles that maintains cellular homeostasis during nutrient deprivation and stress. Autophagy also contributes to the clearance of damaged organelles and aggregate-prone proteins, protection against metabolic stress and DNA damage, and even to longevity of the organism. Defective autophagy has been connected to many human diseases including cancer, myopathies, metabolic diseases, and neurodegenerative diseases.
We and others showed that autophagosomes form in a subcompartment of the endoplasmic reticulum. A flat membrane cistern called the phagophore emerges first, which then elongates and forms a double-membrane bound autophagosome. Autophagosomes acquire hydrolytic capacity by fusing with endosomes and lysosomes. The origin of autophagosome membranes is one of the longest lasting open questions in the field. We have addressed this question using three-dimensional electron microscopy, live-cell imaging and correlative light-electron microscopy.
Eeva-Liisa Eskelinen is the responsible teacher of the course Cell Biology and Histology, aimed for first year students in medicine, dentistry and biomedicine. She is also teaching electron microscopy methods on the course Electron Microscopy in Biomedical Sciences, aimed for MSc students on Biomedical Imaging, and for PhD students interested in the topic.
- ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases (2019) Anwar Tahira, Liu Xiaonan, Suntio Taina, Marjamäki Annika, Biazik Joanna, Chan Edmond Y. W., Varjosalo Markku, Eskelinen Eeva-Liisa
- Large expert-curated database for benchmarking document similarity detection in biomedical literature search (2019)
- Database: The Journal of Biological Databases and Curation
Brown P, Tan AC, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF, Cernava T, Sorzano CO, Yeung AWK, Engel MS, Chandrasekaran AR, Muth T, Staege MS, Daulatabad SV, Widera D, Zhang J, Meule A, Honjo K, Pourret O, Yin CC, Zhang Z, Cascella M, Flegel WA, Goodyear CS, van Raaij MJ, Bukowy-Bieryllo Z, Campana LG, Kurniawan NA, Lalaouna D, Huttner FJ, Ammerman BA, Ehret F, Cobine PA, Tan EC, Han HM, Xia WF, McCrum C, Dings RPM, Marinello F, Nilsson H, Nixon B, Voskarides K, Yang L, Costa VD, Bengtsson-Palme J, Bradshaw W, Grimm DG, Kumar N, Martis E, Prieto D, Sabnis SC, Amer SEDR, Liew AWC, Perco P, Rahimi F, Riva G, Zhang CX, Devkota HP, Ogami K, Basharat Z, Fierz W, Siebers R, Tan KH, Boehme KA, Brenneisen P, Brown JAL, Dalrymple BP, Harvey DJ, Ng G, Werten S, Bleackley M, Dai ZW, Dhariwal R, Gelfer Y, Hartmann MD, Miotla P, Tamaian R, Govender P, Gurney-Champion OJ, Kauppila JH, Zhang XL, Echeverria N, Subhash S, Sallmon H, Tofani M, Bae T, Bosch O, Cuiv PO, Danchin A, Diouf B, Eerola T, Evangelou E, Filipp FV, Klump H, Kurgan L, Smith SS, Terrier O, Tuttle N, Ascher DB, Janga SC, Schulte LN, Becker D, Browngardt C, Bush SJ, Gaullier G, Ide K, Meseko C, Werner GDA, Zaucha J, Al-Farha AA, Greenwald NF, Popoola SI, Rahman MS, Xu JL, Yang SY, Hiroi N, Alper OM, Baker CI, Bitzer M, Chacko G, Debrabant B, Dixon R, Forano E, Gilliham M, Kelly S, Klempnauer KH, Lidbury BA, Lin MZ, Lynch I, Ma WJ, Maibach EW, Mather DE, Nandakumar KS, Ohgami RS, Parchi P, Tressoldi P, Xue Y, Armitage C, Barraud P, Chatzitheochari S, Coelho LP, Diao J, Doxey AC, Gobet A, Hu PZ, Kaiser S, Mitchell KM, Salama MF, Shabalin IG, Song HJ, Stevanovic D, Yadollahpour A, Zeng EL, Zinke K, Alimba CG, Beyene TJ, Cao ZH, Chan SS, Gatchell M, Kleppe A, Piotrowski M, Torga G, Woldesemayat AA, Cosacak MI, Haston S, Ross SA, Williams R, Wong A, Abramowitz MK, Effiong A, Lee SH, Abid MB, Agarabi C, Alaux C, Albrecht DR, Atkins GJ, Beck CR, Bonvin AMJJ, Bourke E, Brand T, Braun RJ, Bull JA, Cardoso P, Carter D, Delahay RM, Ducommun B, Duijf PHG, Epp T, Eskelinen EL, Fallah M, Farber DB, Fernandez-Triana J, Feyerabend F, Florio T, Friebe M, Furuta S, Gabrielsen M, Gruber J, Grybos M, Han Q, Heinrich M, Helantera H, Huber M, Jeltsch A, Jiang F, Josse C, Jurman G, Kamiya H, de Keersmaecker K, Kristiansson E, Leeuw FE, Li J, Liang S, Lopez-Escamez JA, Lopez-Ruiz FJ, Marchbank KJ, Marschalek R, Martin CS, Miele AE, Montagutelli X, Morcillo E, Nicoletti R, Niehof M, O'Toole R, Ohtomo T, Oster H, Palma JA, Paterson R, Peifer M, Portilla M, Portillo MC, Pritchard AL, Pusch S, Raghava GPS, Roberts NJ, Ross K, Schuele B, Sergeant K, Shen J, Stella A, Sukocheva O, Uversky VN, Vanneste S, Villet MH, Viveiros M, Vorholt JA, Weinstock C, Yamato M, Zabetakis I, Zhao X, Ziegler A, Aizat WM, Atlas L, Bridges KM, Chakraborty S, Deschodt M, Domingues HS, Esfahlani SS, Falk S, Guisado JL, Kane NC, Kueberuwa G, Lau CL, Liang D, Liu E, Luu AM, Ma C, Ma LS, Moyer R, Norris AD, Panthee S, Parsons JR, Peng Y, Pinto IM, Reschke CR, Sillanpaa E, Stewart CJ, Uhle F, Yang H, Zhou K, Zhu S, Ashry M, Bergsland N, Berthold M, Chen CE, Colella V, Cuypers M, Eskew EA, Fan X, Gajda M, Gonzalezlez-Prendes R, Goodin A, Graham EB, Groen EJN, Gutierrez-Sacristan A, Habes M, Heffler E, Higginbottom DB, Janzen T, Jayaraman J, Jibb LA, Jongen S, Kinyanjui T, Koleva-Kolarova RG, Li Z, Liu YP, Lund BA, Lussier AA, Ma L, Mier P, Moore MD, Nagler K, Orme MW, Pearson JA, Prajapati AS, Saito Y, Troder SE, Uchendu F, Verloh N, Voutchkova DD, Abu-Zaid A, Bakkach J, Baumert P, Dono M, Hanson J, Herbelet S, Hobbs E, Kulkarni A, Kumar N, Liu SQ, Loft ND, Reddan T, Senghore T, Vindin H, Xu HT, Bannon R, Chen B, Cheung JTK, Cooper J, Esnakula AK, Feghali KA, Ghelardi E, Gnasso A, Horbar J, Lai HM, Li J, Ma L, Ma RY, Pan ZH, Peres MA, Pranata R, Seow E, Sydes M, Testoni I, Westermair AL, Yang Y, Afnan M, Albiol J, Albuquerque LG, Amiya E, Amorim RM, An Q, Andersen SU, Aplin JD, Argyropoulos C, Asmann YW, Assaeed AM, Atanasov AG, Atchison DA, Avery SV, Avillach P, Baade PD, Backman L, Badie C, Baldi A, Ball E, Bardot O, Barnett AG, Basner M, Batra J, Bazanova OM, Beale A, Beddoe T, Bell ML, Berezikov E, Berners-Price S, Bernhardt P, Berry E, Bessa TB, Billington C, Birch J, Blakely RD, Blaskovich MAT, Blum R, Boelaert M, Bogdanos D, Bosch C, Bourgoin T, Bouvard D, Boykin LM, Bradley G, Braun D, Brownlie J, Bruhl A, Burt A, Butler LM, Byrareddy SN, Byrne HJ, Cabantous S, Calatayud S, Candal E, Carlson K, Casillas S, Castelvetro V, Caswell PT, Cavalli G, Cerovsky V, Chagoyen M, Chen CS, Chen DF, Chen H, Chen H, Chen JT, Chen YL, Cheng CX, Cheng JL, Chinapaw M, Chinopoulos C, Cho WCS, Chong L, Chowdhury D, Chwalibog A, Ciresi A, Cockcroft S, Conesa A, Cook PA, Cooper DN, Coqueret O, Corea EM, Costa E, Coupland C, Crawford SY, Cruz AD, Cui HJ, Cui Q, Culver DC, D'Angiulli A, Dahms TES, Daigle F, Dalgleish R, Danielsen HE, Darras S, Davidson SM, Day DA, Degirmenci V, Demaison L, Devriendt K, Ding J, Dogan Y, Dong XC, Donner CF, Dressick W, Drevon CA, Duan HL, Ducho C, Dumaz N, Dwarakanath BS, Ebell MH, Eisenhardt S, Elkum N, Engel N, Erickson TB, Fairhead M, Faville MJ, Fejzo MS, Festa F, Feteira A, Flood-Page P, Forsayeth J, Fox SA, Franks SJ, Frentiu FD, Frilander MJ, Fu XM, Fujita S, Galea I, Galluzzi L, Gani F, Ganpule AP, Garcia-Alix A, Gedye K, Giordano M, Giunta C, Gleeson PA, Goarant C, Gong HP, Gora D, Gough MJ, Goyal R, Graham KE, Grande-Perez A, Graves PM, Greidanus H, Grice D, Grunau C, Gumulya Y, Guo YB, Gurevich VV, Gusev O, Hacker E, Hage SR, Hagen G, Hahn S, Haller DM, Hammerschmidt S, Han JW, Han R, Handfield M, Hapuarachchi HC, Harder T, Hardingham JE, Heck M, Heers M, Hew KF, Higuchi Y, St Hilaire C, Hilton R, Hodzic E, Hone A, Hongoh Y, Hu GK, Huber HP, Hueso LE, Huirne J, Hurt L, Idborg H, Ikeo K, Ingley E, Jakeman PM, Jensen A, Jia H, Jia HS, Jia SQ, Jiang JP, Jiang XY, Jin Y, Jo D, Johnson AM, Johnston M, Jonscher KR, Jorens PG, Jorgensen JOL, Joubert JW, Jung SH, Junior AM, Kahan T, Kamboj SK, Kang YK, Karamanos Y, Karp NA, Kelly R, Kenna R, Kennedy J, Kersten B, Khalaf RA, Khalid JM, Khatlani T, Khider T, Kijanka GS, King SRB, Kluz T, Knox P, Kobayashi T, Koch KW, Kohonen-Corish MRJ, Kong X, Konkle-Parker D, Korpela KM, Kostrikis LG, Kraiczy P, Kratz H, Krause G, Krebsbach PH, Kristensen SR, Kumari P, Kunimatsu A, Kurdak H, Kwon YD, Lachat C, Lagisz M, Laky B, Lammerding J, Lange M, Larrosa M, Laslett AL, LeClair EE, Lee KW, Lee MY, Lee MS, Li GY, Li JS, Lieb K, Lim YY, Lindsey ML, Line PD, Liu DC, Liu FB, Liu HY, Liu HD, Lloyd VK, Lo TW, Locci E, Loidl J, Lorenzen J, Lorkowski S, Lovell NH, Lu H, Lu W, Lu ZY, Luengo GS, Lundh LG, Lysy PA, Mabb A, Mack HG, Mackey DA, Mahdavi SR, Maher P, Maher T, Maity SN, Malgrange B, Mamoulakis C, Mangoni AA, Manke T, Manstead ASR, Mantalaris A, Marsal J, Marschall HU, Martin FL, Martinez-Raga J, Martinez-Salas E, Mathieu D, Matsui Y, Maza E, McCutcheon JE, Mckay GJ, McMillan B, McMillan N, Meads C, Medina L, Merrick BA, Metzger DW, Meunier FA, Michaelis M, Micheau O, Mihara H, Mintz EM, Mizukami T, Moalic Y, Mohapatra DP, Monteiro A, Montes M, Moran JV, Morozov SY, Mort M, Murai N, Murphy DJ, Murphy SK, Murray SA, Naganawa S, Nammi S, Nasios G, Natoli RM, Nguyen F, Nicol C, van Nieuwerburgh F, Nilsen EB, Nobile CJ, O'Mahony M, Ohlsson S, Olatunbosun O, Olofsson P, Ortiz A, Ostrikov K, Otto S, Outeiro TF, Ouyang S, Paganoni S, Page A, Palm C, Paradies Y, Parsons MH, Parsons N, Pascal P, Paul E, Peckham M, Pedemonte N, Pellizzon MA, Petrelli M, Pichugin A, Pinto CJC, Plevris JN, Pollesello P, Polz M, Ponti G, Porcelli P, Prince M, Quinn GP, Quinn TJ, Ramula S, Rappsilber J, Rehfeldt F, Reiling JH, Remacle C, Rezaei M, Riddick EW, Ritter U, Roach NW, Roberts DD, Robles G, Rodrigues T, Rodriguez C, Roislien J, Roobol MJ, Rowe JA, Ruepp A, van Ruitenbeek J, Rust P, Saad S, Sack GH, Santos M, Saudemont A, Sava G, Schrading S, Schramm A, Schreiber M, Schuler S, Schymkowitz J, Sczyrba A, Seib KL, Shi HP, Shimada T, Shin JS, Shortt C, Silveyra P, Skinner D, Small I, Smeets PAM, So PW, Solano F, Sonenshine DE, Song JN, Southall T, Speakman JR, Srinivasan MV, Stabile LP, Stasiak A, Steadman KJ, Stein N, Stephens AW, Stewart DI, Stine K, Storlazzi C, Stoynova NV, Strzalka W, Suarez OM, Sultana T, Sumant AV, Summers MJ, Sun G, Tacon P, Tanaka K, Tang HX, Tanino Y, Targett-Adams P, Tayebi M, Tayyem R, Tebbe CC, Telfer EE, Tempel W, Teodorczyk-Injeyan JA, Thijs G, Thorne S, Thrift AG, Tiffon C, Tinnefeld P, Tjahjono DH, Tolle F, Toth E, del Tredici AL, Tsapas A, Tsirigotis K, Turak A, Tzotzos G, Udo EE, Utsumi T, Vaidyanathan S, Vaillant M, Valsesia A, Vandenbroucke RE, Veiga FH, Vendrell M, Vesk PA, Vickers P, Victor VM, Villemur R, Vohl MC, Voolstra CR, Vuillemin A, Wakelin S, Waldron L, Walsh LJ, Wang AY, Wang F, Wang Y, Watanabe Y, Weigert A, Wen JC, Wham C, White EP, Wiener J, Wilharm G, Wilkinson S, Willmann R, Wilson C, Wirth B, Wojan TR, Wolff M, Wong BM, Wu TW, Wuerbel H, Xiao XS, Xu D, Xu JW, Xu JP, Xue B, Yalcin S, Yan H, Yang EC, Yang SQ, Yang W, Ye YZ, Ye ZQ, Yli-Kauhaluoma J, Yoneyama H, Yu Y, Yuan GC, Yuh CH, Zaccolo M, Zeng C, Zevnik B, Zhang C, Zhang L, Zhang L, Zhang YK, Zhang YS, Zhang ZY, Zhang ZY, Zhao Y, Zhou M, Zuberbier T, Aanei CM, Ahmad R, Al-Lawama M, Alanio A, Allardyce J, Alonso-Caneiro D, Atack JM, Baier D, Bansal A, Benezeth Y, Berbesque C, Berrevoet F, Biedermann PHW, Bijleveld E, Bittner F, Blombach F, den Bos W, Boudreau SA, Bramoweth AD, Braubach O, Cai Y, Campbell M, Cao ZX, Catry T, Chen X, Cheng SQ, Chung HJ, Chavez-Fumagalli MA, Conway A, Costa BM, Cyr N, Dean LT, Denzel MS, Dlamini SV, Dudley KJ, Dufies M, Ecke T, Eckweiler D, Eixarch E, El-Adawy H, Emmrich JV, Eustace AJ, Falter-Wagner CM, Fuss J, Gao JZ, Gill MR, Gloyn L, Goggs R, Govinden U, Greene G, Greiff V, Grundle DS, Gruneberg P, Gumede N, Haore G, Harrison P, Hoenner X, Hojsgaard D, Hori H, Ikonomopoulou MP, Jeurissen P, Johnson DM, Kabra D, Kamagata K, Karmakar C, Kasian O, Kaye LK, Khan MM, Kim YM, Kish JK, Kobold S, Kohanbash G, Kohls G, Kugler JM, Kumar G, Lacy-Colson J, Latif A, Lauschke VM, Li BL, Lim CJ, Liu F, Liu XD, Lu JJ, Lu Q, Mahavadi P, Marzocchi U, McGarrigle CA, van Meerten T, Min R, Moal I, Molari M, Molleman L, Mondal SR, Van de Mortel T, Moss WN, Moultos OA, Mukherjee M, Nakayama K, Narayan E, Navaratnarajah, Neumann PA, Nie JY, Nie YJ, Niemeyer F, Nolan F, Nwaiwu O, Oldenmenger WH, Olumayede E, Ou JH, Pallebage-Gamarallage M, Pearce SP, Pelkonen T, Pelleri MC, Pereira JL, Pheko M, Pinto KA, Piovesan A, Pluess M, Podolsky IM, Prescott J, Qi DC, Qi XS, Raikou VD, Ranft A, Rhodes J, Rotge JY, Rowe AD, Saggar M, Schuon RA, Shahid S, Shalchyan V, Shirvalkar P, Shiryayev O, Singh J, Smout MJ, Soares A, Song CJ, Srivastava K, Srivastava RK, Sun J, Szabo A, Szymanski W, Tai CNP, Takeuchi H, Tanadini-Lang S, Tang F, Tao WY, Theron G, Tian CF, Tian YS, Tuttle LM, Valenti A, Verlot P, Walker M, Wang J, Welter D, Winslade M, Wu DL, Wu YR, Xiao H, Xu BS, Xu J, Xu ZY, Yang DD, Yang MJ, Yankilevich P, You YY, Yu CL, Zhan J, Zhang G, Zhang K, Zhang T, Zhang Y, Zhao GY, Zhao J, Zhou XF, Zhu ZX, Ajani PA, Anazodo UC, Bagloee SA, Bail K, Bar I, Bathelt J, Benkeser D, Bernier ML, Blanchard AM, Boakye DW, Bonatsos V, Boon MH, Bouboulis G, Bromfield E, Brown J, Bul KCM, Burton KJ, Butkowski EG, Carroll G, Chao FQ, Charrier EE, Chen XY, Chen YC, Chenguang, Choi JR, Christoffersen T, Comel JC, Cosse C, Cui YR, van Dessel P, Dhaval, Diodato D, Duffey M, Dutt A, Egea LG, El-Said M, Faye M, Fernandez-Fernandez B, Foley KG, Founou LL, Fu F, Gadelkareem RA, Galimov E, Garip G, Gemmill A, Gouil Q, Grey J, Gridneva Z, Grothe MJ, Grebert T, Guerrero F, Guignard L, Haenssgen MJ, Hasler D, Holgate JY, Huang AC, Hulse-Kemp AM, Jean-Quartier C, Jeon SM, Jia YY, Jutzeler C, Kalatzis P, Karim M, Karsay K, Keitel A, Kempe A, Keown JR, Khoo CM, Khwaja N, Kievit RA, Kosanic A, Koutoukidis DA, Kramer P, Kumar D, Kirag N, Lanza G, Le TD, Leem JW, Leightley D, Leite A, Lercher L, Li Y, Lim RL, Lima LRA, Lin L, Ling T, Liu YC, Liu ZH, Lu Y, Lum FM, Luo H, Machhi J, Macleod A, Macwan I, Madala HR, Madani N, de Maio N, Makowiecki K, Mallinson DJ, Margelyte R, Maria C, Markonis Y, Marsili L, Mavoa S, McWilliams L, Megersa M, Mendes CSM, Menichetti J, Mercieca-Bebber R, Miller JJ, Minde DPM, Minges A, Mishra E, Mishra VR, Moores C, Morrice N, Moskalensky AE, Navarin N, Negera E, Nolet P, Nordberg A, Norden R, Nowicki JP, Olova N, Olszewski P, Onzima R, Pan CL, Park C, Park DI, Park S, Patil CD, Pedro SA, Perry SR, Peter J, Peterson BM, Pezzuolo A, Pozdnyakov I, Qian SY, Qin L, Rafe A, Raote I, Raza A, Rebl H, Refai O, Regan T, Richa T, Richardson MF, Robinson KR, Rossoni L, Rouet R, Safaei S, Schneeberger PHH, Schwotzer D, Sebastian A, Selinski J, Seltmann S, Sha F, Shalev N, Shang JL, Singer J, Singh M, Smith T, Solomon-Moore E, Song LJ, Soraggi S, Stanley R, Steckhan N, Strobl F, Subissi L, Supriyanto I, Surve CR, Suzuki T, Syme C, Sorelius K, Tang Y, Tantawy M, Tennakoon S, Teseo S, Toelzer C, Tomov N, Tovar M, Tran L, Tripathi S, Tuladhar AM, Ukubuiwe AC, Ung COL, Valgepea K, Vatanparast H, Vidal A, Wang F, Wang Q, Watari R, Webster R, Webster R, Wei JN, Wibowo D, Wingenbach TSH, Xavier RM, Xiao SM, Xiong P, Xu SC, Xu SL, Yao RF, Yao W, Yin Q, Yu YB, Zaitsu M, Zeineb Z, Zhan XY, Zhang JL, Zhang RQ, Zhang W, Zhang XL, Zheng S, Zhou BL, Zhou XY, Ahmad H, Akinwumi SA, Albery GF, Alhowimel A, Ali J, Alshehri M, Alsuhaibani M, Anikin A, Azubuike SO, Bach-Mortensen A, Baltiansky L, Bartas M, Belachew KY, Bhardwaj V, Binder K, Bland NS, Boah M, Bullen B, Calabro GE, Callahan TJ, Cao B, Chalmers K, Chang W, Che ZP, Chen ATY, Chen HM, Chen HM, Chen YN, Chen Z, Choi Y, Chowdhury MAK, Christensen MR, Cooke RSC, Cottini M, Covington NV, Cunningham C, Delarocque J, Devos L, Dhar AR, Ding KF, Dong KX, Dong Z, Dreyer N, Ekstrand C, Fardet T, Feleke BE, Feurer T, Freitas A, Gao T, Asefa NG, Giganti F, Grabowski P, Guerra-Mora JR, Guo CY, Guo XY, Gupta H, He SN, Heijne M, Heinemann S, Hogrebe A, Huang ZP, Iskander-Rizk S, Iyer LM, Jahan Y, James AS, Joel E, Joffroy B, Jegousse C, Kambondo G, Karnati P, Kaya C, Ke A, Kelly D, Kickert R, Kidibule PE, Kieselmann JP, Kim HJ, Kitazawa T, Lamberts A, Li Y, Liang HK, Linn SN, Litfin T, Liusuo W, Lygirou V, Mahato AK, Mai ZM, Major RW, Mali S, Mallis P, Mao WZ, Mao WZ, Marvin-Dowle K, Marvin-Dowle K, Mason LD, Merideth B, Merino-Plaza MJ, Merlaen B, Messina R, Mishra AK, Muhammad J, Musinguzi C, Nanou A, Naqash A, Nguyen JT, Nguyen TTH, Ni D, Nida, Notcovich S, Ohst B, Ollivier QR, Osses DF, Peng XD, Plantinga A, Pulia M, Rafiq M, Raman A, Raucher-Chene D, Rawski R, Ray A, Razak LA, Rudolf K, Rusch P, Sadoine ML, Schmidt A, Schurr R, Searles S, Sharma S, Sheehan B, Shi CH, Shohayeb B, Sommerlad A, Strehlow J, Sun XB, Sundar R, Taherzadeh G, Tahir NDM, Tang J, Testa J, Tian ZQ, Tingting Q, Verheijen GP, Vickstrom C, Wang T, Wang XM, Wang ZX, Wei P, Wilson A, Wyart, Yassine AA, Yousefzadeh A, Zare A, Zeng Z, Zhang CR, Zhang HW, Zhang LX, Zhang TC, Zhang WJ, Zhang Z, Zhou JY, Zhu DJ, Adamo V, Adeyemo AA, Aggelidou M, Al-Owaifeer AM, Al-Riyami AZ, Alzghari SK, Andersen V, Angus K, Asaduzzaman M, Asady H, Ato D, Bai XY, Baines RL, Ballantyne M, Ban B, Beck J, Ben-Nafa W, Black E, Blancher A, Blankstein R, Bodagh N, Borges PAV, Brooks A, Brox-Ponce J, Brunetti A, Canham CD, Carninci P, Carvajal R, Chang SC, Chao J, Chatterjee P, Chen H, Chen YC, Chhatriwalla AK, Chikowe I, Chuang TJ, Collevatti RG, Valera-Cornejo DA, Cuenda A, Dao M, Dauga D, Deng Z, Devkota K, Doan LV, Elewa YHA, Fan DS, Faruk M, Feifei S, Ferguson TS, Fleres F, Foster EJ, Foster CS, Furer T, Gao YB, Garcia-Rivera EJ, Gazdar A, George RB, Ghosh S, Gianchecchi E, Gleason JM, Hackshaw A, Hall A, Hall R, Harper P, Hogg WE, Huang GQ, Hunter KE, IJzerman AP, Jesus C, Jian G, Lewis JS, Kanj SS, Kaur H, Kelly S, Kheir F, Kichatova VS, Kiyani M, Klein R, Kovesi T, Kraschnewski JL, Kumar AP, Labutin D, Lazo-Langner A, Leclercq G, Li MT, Li QC, Li TL, Li YZ, Liao WT, Liao ZY, Lin J, Lizer J, Lobreglio G, Lowies C, Lu C, Majeed H, Martin A, Martinez-Sobrido L, Meresh E, Middelveen M, Mohebbi A, Mota J, Mozaheb Z, Muyaya L, Nandhakumar A, Ng SHX, Obeidat M, Oh DH, Owais M, Pace-Asciak P, Panwar A, Park C, Patterson C, Penagos-Tabaree F, Pianosi PT, Pinzi V, Pridans C, Psaroulaki A, Pujala RK, Pulido-Arjona L, Qi PF, Rahman P, Rai NK, Rassaf T, Refardt J, Ricciardi W, Riess O, Rovas A, Sacks FM, Saleh S, Sampson C, Schmutz A, Sepanski R, Sharma N, Singh M, Spearman P, Subramaniapillai M, Swali R, Tan CM, Tellechea JI, Thomas LM, Tong X, Veys R, Vitriol V, Wang HD, Wang JH, Wang JC, Waugh J, Webb SA, Williams BA, Workman AD, Xiang TX, Xie LX, Xu J, Xu TS, Yang CJ, Yoon JG, Yuan CM, Zaritsky A, Zhang Y, Zhao HC, Zuckerman HN, Lyu R, Pullan W, Zhou YQ, Zhou YQ, Lyu R, Pullan W, Zhao HC, Zuckerman HN, Zaritsky A, Zhang Y, Yoon JG, Yuan CM, Xu TS, Yang CJ, Xie LX, Xu J, Williams BA, Webb SA, Xiang TX, Workman AD, Wang JH, Wang HD, Waugh J, Wang JC, Tong X, Thomas LM, Vitriol V, Veys R, Tellechea JI
- Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs (2019) Gu Y, Yakubu Abudu P, Bissa B, Choi SW, Kumar S, Lazareau M, Eskelinen E-L, Johansen T, and Deretic V
- Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform (2019) Maria Zachari, Sigurdur R. Gudmundsson, Ziyue Li, Maria Manifava, Ronak Shah, Matthew Smith, James Stronge, Eleftherios Karanasios, Caterina Piunti, Chieko Kishi-Itakura, Helena Vihinen, Eija Jokitalo, Jun-Lin Guan, Folma Buss, Andrew M. Smith, Simon A. Walker, Eeva-Liisa Eskelinen, Nicholas T. Ktistakis
- Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B (2018) Colecchia D, Stasi M, Leonardi M, Manganelli F, Nolano M, Veneziani BM, Santoro L, Eskelinen EL, Chiariello M, Bucci C
- Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations (2018) Vojo Deretic, Eric Prossnitz, Mark Burge, Matthew J. Campen, Judy Cannon, Ke Jian Liu, Larry A. Sklar, Lee Allers, Sally Ann Garcia, Eric H. Baehrecke, Christian Behrends, Francesco Cecconi, Patrice Codogno, Guang-Chao Chen, Zvulun Elazar, Eeva-Liisa Eskelinen, Bernard Fourie, Devrim Gozuacik, Wanjin Hong, Gokhan Hotamisligi, Marja Jäättelä, Eun-Kyeong Jo, Terje Johansen, Gábor Juhász, Adi Kimchi, Nicholas Ktistakis, Guido Kroemer, Noboru MIzushima, Christian Münz, Fulvio Reggiori, David Rubinsztein, Kevin Ryan, Kate Schroder, Anne Simonsen, Sharon Tooze, Maria I. Vaccaro, Tamotsu Yoshimori, Li Yu, Hong Zhang, Daniel J. Klionsky
- Deficit in PINK1/PARKIN-mediated mitochondrial autophagy at late stages of dystrophic cardiomyopathy (2018) Kang CF, Badr MA, Kyrychenko V, Eskelinen EL, Shirokova N
- GIMAP6 is required for T cell maintenance and efficient autophagy in mice (2018) John C. Pascall, Louise M. C. Webb, Eeva-Liisa Eskelinen, Silvia Innocentin, Noudjoud Attaf-Bouabdallah, Geoffrey W. Butcher
- Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis (2018) Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI
- Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing (2018)
- Nature Reviews Drug Discovery
Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bezard, Greg M. Pastores, David C. Rubinsztein, Ralph A. Nixon, Michael R. Duchen, Giovanna R. Mallucci, Guido Kroemer, Beth Levine, Eeva-Liisa Eskelinen, Fanny Mochel, Michael Spedding, Caroline Louis, Olivier R. Martin, Mark J. Millan
- Roles for RAB24 in autophagy and disease (2018) Ylä-Anttila P., Eskelinen E.
- Vacuole membrane protein 1 marks endoplasmic reticulum subdomains enriched in phospholipid synthesizing enzymes and is required for phosphoinositide distribution (2018) Tabara LC, Vicente JJ, Biazik J, Eskelinen EL, Vincent O, Escalante R
- 2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation (2017) Lai JKF, Sam IC, Verlhac P, Baguet J, Eskelinen EL, Faure M, Chan YF
- Basal Autophagy Is Altered in Lagotto Romagnolo Dogs with an ATG4D Mutation (2017) Syrjä P., Anwar T., Jokinen T., Kyöstilä K., Jäderlund K.H., Cozzi F., Rohdin C., Hahn K., Wohlsein P., Baumgartner W., Henke D., Oevermann A., Sukura A., Leeb T., Lohi H., Eskelinen E-L.
- Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin (2017) Marcassa Elena, Raimondi Marzia, Anwar Tahira, Eskelinen Eeva-Liisa, Myers Michael P., Triolo Gianluca, Schneider Claudio, Demarchi Francesca
- Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells (2017)
- Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Hanna Ruhanen, P.A. Nidhina Haridas, Eeva-Liisa Eskelinen, Ove Eriksson, Vesa M. Olkkonen, Reijo Käkelä
- Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes (2017) Kissing S, Rudnik S, Damme M, Lullmann-Rauch R, Ichihara A, Kornak U, Eskelinen EL, Jabs S, Heeren J, De Brabander JK, Haas A, Saftig P
- Foreword: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (2017) Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging Eeva-Liisa Eskelinen
- Molecular definitions of autophagy and related processes (2017) Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Pedro JMBS, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jaattela M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Munz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan JY, Yue ZY, Zhong Q, Kroemer G, Kroemer G, Zhong Q
- TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation (vol 129, pg 3562, 2016), Correction (2017) Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen EL, Johansen T, Prekeris R, Deretic V
