Autophagy in major human diseases
: Klionsky Daniel J, Petroni Giulia, Amaravadi Ravi K, Baehrecke Eric H, Ballabio Andrea, Boya Patricia, Bravo-San Pedro José Manuel, Cadwell Ken, Cecconi Francesco, Choi Augustine M K, Choi Mary E, Chu Charleen T, Codogno Patrice, Colombo Maria Isabel, Cuervo Ana Maria, Deretic Vojo, Dikic Ivan, Elazar Zvulun, Eskelinen Eeva-Liisa, Fimia Gian Maria, Gewirtz David A, Green Douglas R, Hansen Malene, Jäättelä Marja, Johansen Terje, Juhász Gábor, Karantza Vassiliki, Kraft Claudine, Kroemer Guido, Ktistakis Nicholas T, Kumar Sharad, Lopez-Otin Carlos, Macleod Kay F, Madeo Frank, Martinez Jennifer, Meléndez Alicia, Mizushima Noboru, Münz Christian, Penninger Josef M, Perera Rushika M, Piacentini Mauro, Reggiori Fulvio, Rubinsztein David C, Ryan Kevin M, Sadoshima Junichi, Santambrogio Laura, Scorrano Luca, Simon Hans-Uwe, Simon Anna Katharina, Simonsen Anne, Stolz Alexandra, Tavernarakis Nektarios, Tooze Sharon A, Yoshimori Tamotsu, Yuan Junying, Yue Zhenyu, Zhong Qing, Galluzzi Lorenzo, Pietrocola Federico
Publisher: Embo Press
: 2021
: EMBO Journal
: The EMBO journal
: EMBO J
: e108863
: 40
: 0261-4189
: 1460-2075
DOI: https://doi.org/10.15252/embj.2021108863
: https://research.utu.fi/converis/portal/detail/Publication/66625661
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
