PhD Olli Pentikäinen - UTU Research Portal

Olli Pentikäinen
PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

olli.pentikainen@utu.fi

+358 40 521 6913

Kiinamyllynkatu 10

Turku

ORCID identifier: https://orcid.org/0000-0001-7188-4016

MedChem.fi

Areas of expertise

Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction

Biography

Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)

Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)

Research

Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.

Publications

6 of 7

Development and characterization of GluR5 kainate receptor antagonists (2007)
- Journal of Neurochemistry
Mayo-Martin MB, Dolman NP, More JCA, Alt A, Knauss JL, Pentikainen OT, Glasser CR, Bleakman D, Mayer ML, Collingridge GL, Jane DE
(A1 Refereed original research article in a scientific journal)
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding (2007)
- EMBO Journal
Lad Y, Kiema T, Jiang PJ, Pentikainen OT, Coles CH, Campbell ID, Calderwood DA, Ylaenne J
(A1 Refereed original research article in a scientific journal)
Synthesis and pharmacological characterization of N-3-substituted willardiine derivatives: Role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLU(K5) kainate receptor antagonists (2007)
- Journal of Medicinal Chemistry
Dolman NP, More JCA, Alt A, Knauss JL, Pentikainen OT, Glasser CR, Bleakman D, Mayer ML, Collingridge GL, Jane DE
(A1 Refereed original research article in a scientific journal)
Binding properties of HABA-type azo derivatives to avidin and avidin-related protein 4 (2006)
- Chemistry and Biology
Repo S, Paidanius TA, Hytonen VP, Nyholm TKM, Hailing KK, Huuskonen J, Pentikainen T, Rissanen K, Slotte JP, Airenne TT, Salminen TA, Kulomaa MS, Johnson MS
(A1 Refereed original research article in a scientific journal)
Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors (2006)
- Molecular Pharmacology
Sanders JM, Pentikainen OT, Settimo L, Pentikainen U, Shoji M, Sasaki M, Sakai R, Johnson MS, Swanson GT
(A1 Refereed original research article in a scientific journal)
Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors (2006)
- Molecular Pharmacology
Sanders JM, Pentikainen OT, Settimo L, Pentikainen U, Shoji M, Sasaki M, Sakai R, Johnson MS, Swanson GT
(A1 Refereed original research article in a scientific journal)
New inhibitors of 17 beta-hydroxysteroid dehydrogenase type 1 (2006) Messinger J, Hirvela L, Husen B, Kangas L, Koskimies P, Pentikainen O, Saarenketo P, Thole H
(A1 Refereed original research article in a scientific journal)
Subtype selectivity and flexibility of ionotropic glutamate receptors upon antagonist ligand binding (2006)
- Organic and Biomolecular Chemistry
Pentikainen U, Settimo L, Johnson MS, Pentikainen OT
(A1 Refereed original research article in a scientific journal)
Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo (2006)
- Arthritis and Rheumatism
Marttila-Ichihara F, Smith DJ, Stolen C, Yegutkin GG, Elima K, Mercier N, Kiviranta R, Pihlavisto M, Alaranta S, Pentikainen U, Pentikainen O, Fulop F, Jalkanen S, Salmi M
(A1 Refereed original research article in a scientific journal)
Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors (2005)
- Journal of Pharmacology and Experimental Therapeutics
Sanders JM, Ito K, Settimo L, Pentikainen OT, Shoji M, Sasaki M, Johnson MS, Sakai R, Swanson GT
(A1 Refereed original research article in a scientific journal)
BODIL: a molecular modeling environment for structure-function analysis and drug design (2004)
- Journal of Computer-Aided Molecular Design
Lehtonen JV, Still DJ, Rantanen VV, Ekholm J, Bjorkland D, Iftikhar Z, Huhtala M, Repo S, Jussila A, Jaakkola J, Pentikainen O, Nyronen T, Salminen T, Gyllenberg M, Johnson MS
(A1 Refereed original research article in a scientific journal)
Chicken avidin-related protein 4/5 shows superior thermal stability when compared to avidin while retaining high affinity to biotin (2004)
- Biophysical Journal
Hytonen VP, Nyholm TKM, Pentikainen OT, Vaarno J, Porkka EJ, Nordlund HR, Johnson MS, Slotte JP, Laitinen OH, Kulomaa MS
(A1 Refereed original research article in a scientific journal)
Chicken avidin-related protein 4/5 shows superior thermal stability when compared with avidin while retaining high affinity to biotin (2004)
- Journal of Biological Chemistry
Hytonen VP, Nyholm TKM, Pentikainen OT, Vaarno J, Porkka EJ, Nordlund HR, Johnson MS, Slotte JP, Laitinen OH, Kulomaa MS
(A1 Refereed original research article in a scientific journal)
Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes (2004) Karisola P, Mikkola J, Kalkkinen N, Airenne KJ, Laitinen OH, Repo S, Pentikainen OT, Reunala T, Turjanmaa K, Johnson MS, Palosuo T, Kulomaa MS, Alenius H
(A1 Refereed original research article in a scientific journal)
Jararhagin-derived RKKH peptides induce structural changes in alpha I-1 domain of human integrin alpha(1)beta(1) (2004)
- Journal of Biological Chemistry
Nymalm Y, Puranen JS, Nyholm TKM, Kapyla J, Kidron H, Pentikainen OT, Airenne TT, Heino J, Slotte JP, Johnson MS, Salminen TA
(A1 Refereed original research article in a scientific journal)
Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands (2004)
- Journal of Structural Biology
Moretti L, Pentikainen OT, Settimo L, Johnson MS
(A1 Refereed original research article in a scientific journal)
alpha(11)beta(1) integrin recognizes the GFOGER sequence in interstitial collagens (2003)
- Journal of Biological Chemistry
Zhang WM, Kapyla J, Puranen JS, Knight CG, Tiger CF, Pentikainen OT, Johnson MS, Farndale RW, Heino J, Gullberg D
(A1 Refereed original research article in a scientific journal)
Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2 alpha,3 beta,4 beta)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid (kainate) receptors: a molecular modeling study (2003)
- Biochemical Pharmacology
Pentikainen OT, Settimo L, Keinanen K, Johnson MS
(A1 Refereed original research article in a scientific journal)
Antiferritin VL homodimer binds human spleen ferritin with high specificity (2002)
- Journal of Structural Biology
Nymalm Y, Kravchuk Z, Salminen T, Chumanevich AA, Dubnovitsky AP, Kankare J, Pentikainen O, Lehtonen J, Arosio P, Martsev S, Johnson MS
(A1 Refereed original research article in a scientific journal)
Chicken avidin-related proteins show altered biotin-binding and physico-chemical properties as compared with avidin (2002)
- Biochemical Journal
Laitinen OH, Hytonen VP, Ahlroth MK, Pentikainen OT, Gallagher C, Nordlund HR, Ovod V, Marttila AT, Porkka E, Heino S, Johnson MS, Airenne KJ, Kulomaa MS
(A1 Refereed original research article in a scientific journal)