Olli Pentikäinen
PhD
olli.pentikainen@utu.fi +358 40 521 6913 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0001-7188-4016 |
Areas of expertise
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Computer-Dependent Drug Discovery; Molecular Modeling; Protein structure-function relationship; Protein-protein interaction
Biography
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Education:
MSc in (organic) chemistry 1995 (University of Joensuu, Finland)
PhD in Biochemistry 2003 (Åbo Akademi University)
Adjunct Professor in Biochemistry 2005- (University of Turku)
Positions:
2017- Professor of Medicinal Chemistry (University of Turku) 8/2017
2011- Senior Lecturer in Cell and Molecular Biology (University of Jyväskylä)
2015 Visiting Senior Scientist (University of Innsbruck, Austria)
2005-2006 Visiting Senior Scientist (University of Bristol, UK)
1999-2005 Manager in Molecular Discovery (FBD Ltd)
Research
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Our research focuses on discovery of efficient drug candidates and development of novel methods for that purpose. Especially our research on cancer drug targets that have been considered highly difficult, together with risk analysis of drug candidates, pave the road for safer drugs.
Publications 
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- Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1 (2024)
- Briefings in Bioinformatics
(A1 Refereed original research article in a scientific journal) - Building shape-focused pharmacophore models for effective docking screening (2024)
- Journal of cheminformatics
(A1 Refereed original research article in a scientific journal) - Oxazolidinones: Are they only good for the discovery of antibiotics? A worm's eye view (2023)
- Journal of Molecular Structure
(A2 Refereed review article in a scientific journal ) - Virtual Screening Strategy to Identify Retinoic Acid-Related Orphan Receptor γt Modulators (2023)
- Molecules
(A1 Refereed original research article in a scientific journal) - Computational Study on the Inhibitory Effect of Natural Compounds against the SARS-CoV-2 Proteins (2022)
- Bioinorganic Chemistry and Applications
(A1 Refereed original research article in a scientific journal) - Ligand-Enhanced Negative Images Optimized for Docking Rescoring (2022)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Optimization of Cavity-Based Negative Images to Boost Docking Enrichment in Virtual Screening (2022)
- Journal of Chemical Information and Modeling
(A1 Refereed original research article in a scientific journal) - Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase (2022)
- Journal of Enzyme Inhibition and Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Sdfconf: A Novel, Flexible, and Robust Molecular Data Management Tool (2022)
- Journal of Chemical Information and Modeling
(A1 Refereed original research article in a scientific journal) - A holistic view on c-Kit in cancer: Structure, signaling, pathophysiology and its inhibitors (2021)
- BBA - Reviews on Cancer
(A2 Refereed review article in a scientific journal ) - Coumarins as Tool Compounds to Aid the Discovery of Selective Function Modulators of Steroid Hormone Binding Proteins (2021)
- Molecules
(A2 Refereed review article in a scientific journal ) - Detection of binding sites on SARS-CoV-2 Spike protein receptor-binding domain by molecular dynamics simulations in mixed solvents (2021)
- IEEE/ACM Transactions on Computational Biology and Bioinformatics
(A1 Refereed original research article in a scientific journal) - Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13 (2021)
- Xenobiotica
(A1 Refereed original research article in a scientific journal) - Negative Image-Based Rescoring: Using Cavity Information to Improve Docking Screening (2021) Protein-Ligand Interactions and Drug Design Pentikäinen Olli T., Postila Pekka A.
(A3 Refereed book chapter or chapter in a compilation book) - Negative Image-Based Screening: Rigid Docking Using Cavity Information (2021) Protein-Ligand Interactions and Drug Design Postila Pekka A., Kurkinen Sami T., Pentikäinen Olli T.
(A3 Refereed book chapter or chapter in a compilation book) - Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling (2021)
- ACS Omega
(A1 Refereed original research article in a scientific journal) - Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro (2020)
- International Journal of Molecular Sciences
(A2 Refereed review article in a scientific journal ) - Cyanidin-3-glucoside binds to talin and modulates colon cancer cell adhesions and 3D growth (2020)
- FASEB Journal
(A1 Refereed original research article in a scientific journal) - Inhibition of human CYP1 enzymes by a classical inhibitor α-naphthoflavone and a novel inhibitor N-(3, 5-dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study (2020)
- Chemical Biology and Drug Design
(A1 Refereed original research article in a scientific journal) - Inhibition of Pneumolysin Cytotoxicity by Hydrolysable Tannins (2020)
- Antibiotics
(A1 Refereed original research article in a scientific journal)
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