MD/PhD Olli Raitakari - UTU Research Portal

Olli Raitakari
MD/PhD

- Professor,
Cardiovascular Medicine (CAPC) (Centre for Population Health Research (POP Centre))
- ,
InFLAMES Flagship (Faculty of Medicine)

olli.raitakari@utu.fi

+358 29 450 2304

Kiinamyllynkatu 10

Turku

ORCID identifier: https://orcid.org/0000-0001-9365-3702

10_representative_publications.pdf

Areas of expertise

cardiovascular and metabolic diseases; risk factors; vascular epidemiology; genetic epidemiology; epidemiology; dietary intervention; cohort studies; follow-up studies

Biography

EDUCATION AND DEGREES

2001   Docent in Clinical Physiology
1997-1999  Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997   Docent in Epidemiology
1996   Specialist in Clinical Physiology
1995   Doctorate, PhD
1989   Licentiate in Medicine, MD

CURRENT POSITIONS

2017- Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and
Preventive Cardiovascular Medicine, University of Turku, Finland

PAST POSITIONS

2012-2016 Academy Professor, University of Turku

2007-2016 Professor in Cardiovascular Medicine (part time), University of Turku

2007-2008 Senior Scientist Grant, Academy of Finland

2004-2016 Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
University Hospital (leave of absence 2012-2016)

2002-2004 Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital

2002 (1 mo) Head of Nuclear Medicine Department, Turku University Hospital

2000-2003 (3 mo) Head of Clinical Physiology Department, Turku University Hospital

2000-2005 Senior Fellow Post, Academy of Finland

1998-2000 Postdoctoral Research Post, Academy of Finland

1996-1997 Consultant in Clinical Physiology, Turku University Hospital

1991-1996 Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical
Physiology, Turku University Hospital

1988-1990 Positions as General Practioner and Resident in Internal Medicine or Surgery

Research

Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.

Publications

37 of 51

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation (2015)
- Nature Genetics
Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang WH, Kelly TN, Saleheen D, Lehne B, Leach IM, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li HX, Mok ZY, Nakatochi M, Sapari NS, Saxena R, Stewart AFR, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Alves ADC, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytikainen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Bryan MS, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang YH, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu DF, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husemoen LLN, Hwang JY, Ichihara S, Igase M, Isono M, Justesen JM, Katsuy T, Kibriya MG, Kim YJ, Kishimoto M, Koh WP, Kohara K, Kumari M, Kwek K, Lee NR, Lee J, Liao JM, Lieb W, Liewald DCM, Matsubara T, Matsushita Y, Meitinger T, Mihailov E, Milani L, Mills R, Mononen N, Muller-Nurasyid M, Nabika T, Nakashima E, Ng HK, Nikus K, Nutile T, Ohkubo T, Ohnaka K, Parish S, Paternoster L, Peng H, Peters A, Pham ST, Pinidiyapathirage MJ, Rahman M, Rakugi H, Rolandsson O, Rozario MA, Ruggiero D, Sala CF, Sarju R, Shimokawa K, Snieder H, Sparso T, Spiering W, Starr JM, Stott DJ, Stram DO, Sugiyama T, Szymczak S, Tang WHW, Tong L, Trompet S, Turjanmaa V, Ueshima H, Uitterlinden AG, Umemura S, Vaarasmaki M, van Dam RM, van Gilst WH, van Veldhuisen DJ, Viikari JS, Waldenberger M, Wang YQ, Wang AL, Wilson R, Wong TY, Xiang YB, Yamaguchi S, Ye XW, Young RD, Young TL, Yuan JM, Zhou XY, Asselbergs FW, Ciullo M, Clarke R, Deloukas P, Franke A, Franks PW, Franks S, Friedlander Y, Gross MD, Guo ZR, Hansen T, Jarvelin MR, Jorgensen T, Jukema JW, Kahonen M, Kajio H, Kivimaki M, Lee JY, Lehtimaki T, Linneberg A, Miki T, Pedersen O, Samani NJ, Sorensen TIA, Takayanagi R, Toniolo D, Ahsan H, Allayee H, Chen YT, Danesh J, Deary IJ, Franco OH, Franke L, Heijman BT, Holbrook JD, Isaacs A, Kim BJ, Lin X, Liu JJ, Marz W, Metspalu A, Mohlke KL, Sanghera DK, Shu XO, van Meurs JBJ, Vithana E, Wickremasinghe AR, Wijmenga C, Wolffenbuttel BHW, Yokota M, Zheng W, Zhu DL, Vineis P, Kyrtopoulos SA, Kleinjans JCS, McCarthy MI, Soong R, Gieger C, Scott J, Teo YY, He J, Elliott P, Tai ES, van der Harst P, Kooner JS, Chambers JC
(A1 Refereed original research article in a scientific journal)
TV Viewing and cognitive performance in early midlife. The cardiovascular risk in young Finns study. (2015)
- Medicine and Science in Sports and Exercise
Helajärvi Harri, Rovio Suvi, Pahkala Katja, Heinonen Olli J, Tammelin Tuija, Viikari Jorma, Raitakari Olli T
(Other publication)
Vigorous physical activity and carotid distensibility in young and mid-aged adults (2015)
- Hypertension Research
Huynh QL, Blizzard CL, Raitakari O, Sharman JE, Magnussen CG, Dwyer T, Juonala M, Kahonen M, Venn AJ
(A1 Refereed original research article in a scientific journal)
Active commuting from youth to adulthood and as a predictor of physical activity in early midlife: The Young Finns Study (2014)
- Preventive Medicine
Yang XL, Telama R, Hirvensalo M, Tammelin T, Viikari JSA, Raitakari OT
(A1 Refereed original research article in a scientific journal)
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos (2014)
- Nature Communications
Ko A, Cantor RM, Weissglas-Volkov D, Nikkola E, Reddy PMVL, Sinsheimer JS, Pasaniuc B, Brown R, Alvarez M, Rodriguez A, Rodriguez-Guillen R, Bautista IC, Arellano-Campos O, Munoz-Hernandez LL, Salomaa V, Kaprio J, Jula A, Jauhiainen M, Heliovaara M, Raitakari O, Lehtimaki T, Eriksson JG, Perola M, Lohmueller KE, Matikainen N, Taskinen MR, Rodriguez-Torres M, Riba L, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P
(A1 Refereed original research article in a scientific journal)
A metabolic view on menopause and ageing (2014)
- Nature Communications
Auro K, Joensuu A, Fischer K, Kettunen J, Salo P, Mattsson H, Niironen M, Kaprio J, Eriksson JG, Lehtimaki T, Raitakari O, Jula A, Tiitinen A, Jauhiainen M, Soininen P, Kangas AJ, Kahonen M, Havulinna AS, Ala-Korpela M, Salomaa V, Metspalu A, Perola M
(A1 Refereed original research article in a scientific journal)
Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression (2014)
- Bioinformatics
Marttinen P, Pirinen M, Sarin AP, Gillberg J, Kettunen J, Surakka I, Kangas AJ, Soininen P, O'Reilly P, Kaakinen M, Kahonen M, Lehtimaki T, Ala-Korpela M, Raitakari OT, Salomaa V, Jarvelin MR, Ripatti S, Kaski S
(A1 Refereed original research article in a scientific journal)
Association of physical activity in childhood and early adulthood with carotid artery elasticity 21 years later: the cardiovascular risk in Young Finns Study. (2014)
- Journal of the American Heart Association
Pälve KS, Pahkala K, Magnussen CG, Koivistoinen T, Juonala M, Kähönen M, Lehtimäki T, Rönnemaa T, Viikari JS, Raitakari OT
(A1 Refereed original research article in a scientific journal)
Association of thyrotropin with arterial pulse wave velocity in young adults: The Cardiovascular Risk in Young Finns Study (2014)
- Scandinavian Journal of Clinical and Laboratory Investigation
Hjelt S., Heikki Aatola M., Kähönen M., Juonala M., Koivistoinen T., Lehtimäki T., Viikari J., Raitakari O., Laitinen T., Hutri-Kähönen N.
(A1 Refereed original research article in a scientific journal)
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study (2014)
- Lancet Diabetes and Endocrinology
Vimaleswaran KS, Cavadino A, Berry DJ, Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJL, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D, Zgaga L, Thiering E, Vitart V, Fraser RM, Huffman JE, de Boer RA, Schottker B, Saum KU, McCarthy MI, Dupuis J, Herzig KH, Sebert S, Pouta A, Laitinen J, Kleber ME, Navis G, Lorentzon M, Jameson K, Arden N, Cooper JA, Acharya J, Hardy R, Raitakari O, Ripatti S, Billings LK, Lahti J, Osmond C, Penninx BW, Rejnmark L, Lohman KK, Paternoster L, Stolk RP, Hernandez DG, Byberg L, Hagstrom E, Melhus H, Ingelsson E, Mellstrom D, Ljunggren O, Tzoulaki I, McLachlan S, Theodoratou E, Tiesler CMT, Jula A, Navarro P, Wright AF, Polasek O, Hayward C, Wilson JF, Rudan I, Salomaa V, Heinrich J, Campbell H, Price JF, Karlsson M, Lind L, Michaesson K, Bandinelli S, Frayling TM, Hartman CA, Sorensen TIA, Kritchevsky SB, Flo BLLJGEJC, Eriksson JG, Florez JC, Spector TD, Lehtimaki T, Kuh D, Humphries SE, Cooper C, Ohlsson C, Marz W, de Borst MH, Kumari M, Kivimaki M, Wang TJ, Power C, Brenner H, Grimnes G, van der Harst P, Snieder H, Hingorani AD, Pilz S, Whittaker JC, Jarvelin MR, Hypponen E
(A1 Refereed original research article in a scientific journal)
Biomarkers and long-term labour market outcomes: the case of creatine (2014) Böckerman Petri, Bryson Alex, Viinikainen Jutta, Hakulinen Christian, Pulkki-Raback Laura, Raitakari Olli, Pehkonen Jaakko
(D4 Published development or research report or study )
Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome The cardiovascular risk in Young Finns Study (2014)
- Molecular and Cellular Endocrinology
Raitoharju E, Seppala I, Oksala N, Lyytikainen LP, Raitakari O, Viikari J, Ala-Korpela M, Soininen P, Kangas AJ, Waldenberger M, Klopp N, Illig T, Leiviska J, Loo BM, Hutri-Kahonen N, Kahonen M, Laaksonen R, Lehtimaki T
(A1 Refereed original research article in a scientific journal)
Cardiovascular risk factors in 2011 and secular trends since 2007: The Cardiovascular Risk in Young Finns Study. (2014)
- Scandinavian Journal of Public Health
Nuotio J, Oikonen M, Magnussen CG, Jokinen E, Laitinen T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Taittonen L, Tossavainen P, Jula A, Loo BM, Viikari JS, Raitakari OT, Juonala M
(A1 Refereed original research article in a scientific journal)
Cardiovascular risk prediction in children and adolescents (2014)
- Clinical Biochemistry
Raitakari OT
(B1 Non-refereed article in a scientific journal)
Carotid artery elasticity decreases during pregnancy - the Cardiovascular Risk in Young Finns study (2014)
- BMC Pregnancy and Childbirth
Karkkainen H, Saarelainen H, Valtonen P, Laitinen T, Raitakari OT, Juonala M, Kahonen M, Hutri-Kahonen N, Heinonen S, Laitinen T
(A1 Refereed original research article in a scientific journal)
Childhood and adult socio-economic position and social mobility as determinants of low back pain outcomes (2014)
- European Journal of Pain
Lallukka T, Viikari-Juntura E, Raitakari OT, Kahonen M, Lehtimaki T, Viikari J, Solovieva S
(A1 Refereed original research article in a scientific journal)
Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation (2014)
- PLoS Genetics
Tukiainen T, Pirinen M, Sarin AP, Ladenvall C, Kettunen J, Lehtimaki T, Lokki ML, Perola M, Sinisalo J, Vlachopoulou E, Eriksson JG, Groop L, Jula A, Jarvelin MR, Raitakari OT, Salomaa V, Ripatti S
(A1 Refereed original research article in a scientific journal)
Defining the role of common variation in the genomic and biological architecture of adult human height (2014)
- Nature Genetics
Wood A., Esko T., Yang J., Vedantam S., Pers T., Gustafsson S., Chu A., Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich M., Croteau-Chonka D., Day F., Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson A., Karjalainen J., Lo K., Locke A., Mägi R., Mihailov E., Porcu E., Randall J., Scherag A., Vinkhuyzen A., Westra H., Winkler T., Workalemahu T., Zhao J., Absher D., Albrecht E., Anderson D., Baron J., Beekman M., Demirkan A., Ehret G., Feenstra B., Feitosa M., Fischer K., Fraser R., Goel A., Gong J., Justice A., Kanoni S., Kleber M., Kristiansson K., Lim U., Lotay V., Lui J., Mangino M., Leach I., Medina-Gomez C., Nalls M., Nyholt D., Palmer C., Pasko D., Pechlivanis S., Prokopenko I., Ried J., Ripke S., Shungin D., Stancáková A., Strawbridge R., Sung Y., Tanaka T., Teumer A., Trompet S., Van Der Laan S., Van Setten J., Van Vliet-Ostaptchouk J., Wang Z., Yengo L., Zhang W., Afzal U., Ärnlöv J., Arscott G., Bandinelli S., Barrett A., Bellis C., Bennett A., Berne C., Blüher M., Bolton J., Böttcher Y., Boyd H., Bruinenberg M., Buckley B., Buyske S., Caspersen I., Chines P., Clarke R., Claudi-Boehm S., Cooper M., Daw E., De Jong P., Deelen J., Delgado G., Denny J., Dhonukshe-Rutten R., Dimitriou M., Doney A., Dörr M., Eklund N., Eury E., Folkersen L., Garcia M., Geller F., Giedraitis V., Go A., Grallert H., Grammer T., Gräßler J., Grönberg H., De Groot L., Groves C., Haessler J., Hall P., Haller T., Hallmans G., Hannemann A., Hartman C., Hassinen M., Hayward C., Heard-Costa N., Helmer Q., Hemani G., Henders A., Hillege H., Hlatky M., Hoffmann W., Hoffmann P., Holmen O., Houwing-Duistermaat J., Illig T., Isaacs A., James A., Jeff J., Johansen B., Johansson Å., Jolley J., Juliusdottir T., Junttila J., Kho A., Kinnunen L., Klopp N., Kocher T., Kratzer W., Lichtner P., Lind L., Lindström J., Lobbens S., Lorentzon M., Lu Y., Lyssenko V., Magnusson P., Mahajan A., Maillard M., McArdle W., McKenzie C., McLachlan S., McLaren P., Menni C., Merger S., Milani L., Moayyeri A., Monda K., Morken M., Müller G., Müller-Nurasyid M., Musk A., Narisu N., Nauck M., Nolte I., Nöthen M., Oozageer L., Pilz S., Rayner N., Renstrom F., Robertson N., Rose L., Roussel R., Sanna S., Scharnagl H., Scholtens S., Schumacher F., Schunkert H., Scott R., Sehmi J., Seufferlein T., Shi J., Silventoinen K., Smit J., Smith A., Smolonska J., Stanton A., Stirrups K., Stott D., Stringham H., Sundström J., Swertz M., Syvänen A., Tayo B., Thorleifsson G., Tyrer J., Van Dijk S., Van Schoor N., Van Der Velde N., Van Heemst D., Van Oort F., Vermeulen S., Verweij N., Vonk J., Waite L., Waldenberger M., Wennauer R., Wilkens L., Willenborg C., Wilsgaard T., Wojczynski M., Wong A., Wright A., Zhang Q., Arveiler D., Bakker S., Beilby J., Bergman R., Bergmann S., Biffar R., Blangero J., Boomsma D., Bornstein S., Bovet P., Brambilla P., Brown M., Campbell H., Caulfield M., Chakravarti A., Collins R., Collins F., Crawford D., Cupples L., Danesh J., De Faire U., Den Ruijter H., Erbel R., Erdmann J., Eriksson J., Farrall M., Ferrannini E., Ferrières J., Ford I., Forouhi N., Forrester T., Gansevoort R., Gejman P., Gieger C., Golay A., Gottesman O., Gudnason V., Gyllensten U., Haas D., Hall A., Harris T., Hattersley A., Heath A., Hengstenberg C., Hicks A., Hindorff L., Hingorani A., Hofman A., Hovingh G., Humphries S., Hunt S., Hypponen E., Jacobs K., Jarvelin M., Jousilahti P., Jula A., Kaprio J., Kastelein J., Kayser M., Kee F., Keinanen-Kiukaanniemi S., Kiemeney L., Kooner J., Kooperberg C., Koskinen S., Kovacs P., Kraja A., Kumari M., Kuusisto J., Lakka T., Langenberg C., Le Marchand L., Lehtimäki T., Lupoli S., Madden P., Männistö S., Manunta P., Marette A., Matise T., McKnight B., Meitinger T., Moll F., Montgomery G., Morris A., Morris A., Murray J., Nelis M., Ohlsson C., Oldehinkel A., Ong K., Ouwehand W., Pasterkamp G., Peters A., Pramstaller P., Price J., Qi L., Raitakari O., Rankinen T., Rao D., Rice T., Ritchie M., Rudan I., Salomaa V., Samani N., Saramies J., Sarzynski M., Schwarz P., Sebert S., Sever P., Shuldiner A., Sinisalo J., Steinthorsdottir V., Stolk R., Tardif J., Tönjes A., Tremblay A., Tremoli E., Virtamo J., Vohl M., Amouyel P., Asselbergs F., Assimes T., Bochud M., Boehm B., Boerwinkle E., Bottinger E., Bouchard C., Cauchi S., Chambers J., Chanock S., Cooper R., De Bakker P., Dedoussis G., Ferrucci L., Franks P., Froguel P., Groop L., Haiman C., Hamsten A., Hayes M., Hui J., Hunter D., Hveem K., Jukema J., Kaplan R., Kivimaki M., Kuh D., Laakso M., Liu Y., Martin N., März W., Melbye M., Moebus S., Munroe P., Njølstad I., Oostra B., Palmer C., Pedersen N., Perola M., Pérusse L., Peters U., Powell J., Power C., Quertermous T., Rauramaa R., Reinmaa E., Ridker P., Rivadeneira F., Rotter J., Saaristo T., Saleheen D., Schlessinger D., Slagboom P., Snieder H., Spector T., Strauch K., Stumvoll M., Tuomilehto J., Uusitupa M., Van Der Harst P., Völzke H., Walker M., Wareham N., Watkins H., Wichmann H., Wilson J., Zanen P., Deloukas P., Heid I., Lindgren C., Mohlke K., Speliotes E., Thorsteinsdottir U., Barroso I., Fox C., North K., Strachan D., Beckmann J., Berndt S., Boehnke M., Borecki I., McCarthy M., Metspalu A., Stefansson K., Uitterlinden A., Van Duijn C., Franke L., Willer C., Price A., Lettre G., Loos R., Weedon M., Ingelsson E., O'Connell J., Abecasis G., Chasman D., Goddard M., Visscher P., Hirschhorn J., Frayling T.
(A1 Refereed original research article in a scientific journal)
Depressive Symptoms are Associated with Lower Bone Mineral Density in Young Adults with High Job Strain. The Cardiovascular Risk in Young Finns Study. (2014)
- International Journal of Behavioral Medicine
Oikonen M, Hintsanen M, Laaksonen M, Mikkilä V, Kähönen M, Lehtimäki T, Pulkki-Råback L, Viikari JS, Keltikangas-Järvinen L, Raitakari OT
(A1 Refereed original research article in a scientific journal)
Determinants of exercise peak arterial blood pressure, circulatory power, and exercise cardiac power in a population based sample of Finnish male and female aged 30 to 47 years: the Cardiovascular Risk in Young Finns Study (2014)
- BMC Cardiovascular Disorders
Hulkkonen J, Aatola H, Palve K, Lehtimaki T, Hutri-Kahonen N, Viikari JSA, Raitakari OT, Kahonen M
(A1 Refereed original research article in a scientific journal)