Metabolite Profiling and Cardiovascular Event Risk A Prospective Study of 3 Population-Based Cohorts - UTU Research Portal

A1 Refereed original research article in a scientific journal

Metabolite Profiling and Cardiovascular Event Risk A Prospective Study of 3 Population-Based Cohorts

Authors: Wurtz P, Havulinna AS, Soininen P, Tynkkynen T, Prieto-Merino D, Tillin T, Ghorbani A, Artati A, Wang Q, Tiainen M, Kangas AJ, Kettunen J, Kaikkonen J, Mikkila V, Jula A, Kahonen M, Lehtimaki T, Lawlor DA, Gaunt TR, Hughes AD, Sattar N, Illig T, Adamski J, Wang TJ, Perola M, Ripatti S, Vasan RS, Raitakari OT, Gerszten RE, Casas JP, Chaturvedi N, Ala-Korpela M, Salomaa V

Publisher: LIPPINCOTT WILLIAMS & WILKINS

Publication year: 2015

Journal: Circulation

Journal name in source: CIRCULATION

Journal acronym: CIRCULATION

Volume: 131

Issue: 9

First page : 774

Last page: 785

Number of pages: 37

ISSN: 0009-7322

DOI: https://doi.org/10.1161/CIRCULATIONAHA.114.013116

Abstract

Conclusions-Metabolite profiling in large prospective cohorts identified phenylalanine, monounsaturated fatty acids, and polyunsaturated fatty acids as biomarkers for cardiovascular risk. This study substantiates the value of high-throughput metabolomics for biomarker discovery and improved risk assessment.