A1 Refereed original research article in a scientific journal
Metabolite Profiling and Cardiovascular Event Risk A Prospective Study of 3 Population-Based Cohorts
Authors: Wurtz P, Havulinna AS, Soininen P, Tynkkynen T, Prieto-Merino D, Tillin T, Ghorbani A, Artati A, Wang Q, Tiainen M, Kangas AJ, Kettunen J, Kaikkonen J, Mikkila V, Jula A, Kahonen M, Lehtimaki T, Lawlor DA, Gaunt TR, Hughes AD, Sattar N, Illig T, Adamski J, Wang TJ, Perola M, Ripatti S, Vasan RS, Raitakari OT, Gerszten RE, Casas JP, Chaturvedi N, Ala-Korpela M, Salomaa V
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2015
Journal: Circulation
Journal name in source: CIRCULATION
Journal acronym: CIRCULATION
Volume: 131
Issue: 9
First page : 774
Last page: 785
Number of pages: 37
ISSN: 0009-7322
DOI: https://doi.org/10.1161/CIRCULATIONAHA.114.013116
Conclusions-Metabolite profiling in large prospective cohorts identified phenylalanine, monounsaturated fatty acids, and polyunsaturated fatty acids as biomarkers for cardiovascular risk. This study substantiates the value of high-throughput metabolomics for biomarker discovery and improved risk assessment.