Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates - UTU Research Portal

A1 Refereed original research article in a scientific journal

Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates

Authors: Wang Q, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Puukka K, Ruokonen A, Viikari J, Kahonen M, Lehtimaki T, Salomaa V, Perola M, Smith GD, Raitakari OT, Jarvelin MR, Wurtz P, Kettunen J, Ala-Korpela M

Publisher: OXFORD UNIV PRESS

Publication year: 2015

Journal: International Journal of Epidemiology

Journal name in source: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Journal acronym: INT J EPIDEMIOL

Volume: 44

Issue: 2

First page : 623

Last page: 637

Number of pages: 15

ISSN: 0300-5771

eISSN: 1464-3685

DOI: https://doi.org/10.1093/ije/dyv093

Abstract

Conclusion: Circulating SHBG is strongly associated with systemic metabolism and predictive for insulin resistance and diabetes. The weaker causal estimates suggest that the observational associations are partly confounded rather than conferred directly via circulating SHBG.