Pasi Virta
Professor
pamavi@utu.fi +358 29 450 3209 +358 50 328 5719 |
Synthesis of oligonucleotide, peptide nucleic acid, peptide (including antibodies) and carbohydrate conjugates, Drug delivery strategies of oligonucleotides, mechanistic studies of higher order secondary structures of nucleic acids, 19F NMR spectroscopy, DNA-templated synthesis, aqueous glycosylation
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- Synthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules (2022)
- ACS Omega
- The DNA polymerase of bacteriophage YerA41 replicates its T-modified DNA in a primer-independent manner (2022)
- Nucleic Acids Research
- The role of the maleimide ring system on the structure-activity relationship of showdomycin (2022)
- European Journal of Medicinal Chemistry
- Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core (2021)
- Bioconjugate Chemistry
- Covalently Mercurated Molecular Beacon for Discriminating the Canonical Nucleobases (2021)
- ChemBioChem
- Drug-to-Antibody Ratio Estimation via Proteoform Peak Integration in the Analysis of Antibody-Oligonucleotide Conjugates with Orbitrap Fourier Transform Mass Spectrometry (2021)
- Analytical Chemistry
- Expanding the Scope of the Cleavable N-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates (2021)
- Molecules
- More versatile synthesis of oligonucleotides (2021)
- Science
- Stability of the Phosphotriester PDE6D Inhibitors (2021)
- ChemistrySelect
- Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support (2021)
- RSC Advances
- The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases (2021)
- Nature Communications
- Conjugation of Oligonucleotides to Peptide Aldehydes via a pH-Responsive N-Methoxyoxazolidine Linker (2020)
- Organic Letters
- Immobilized Carbohydrates for Preparation of 3'-Glycoconjugated Oligonucleotides (2020)
- Current Protocols in Nucleic Acid Chemistry
- PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity (2020)
- ACS Omega
- Site-Specific Linking of an Oligonucleotide to Mono- and Bivalent Recombinant Antibodies with SpyCatcher-SpyTag System for Immuno-PCR (2020)
- ACS Omega
- 3-Fluoro-2-mercuri-6-methylaniline Nucleotide as a High-Affinity Nucleobase-Specific Hybridization Probe (2019)
- Bioconjugate Chemistry
- Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
- Scientific Reports
- gamma-(S)-Guanidinylmethyl-Modified Triplex-Forming Peptide Nucleic Acids Increase Hoogsteen-Face Affinity for a MicroRNA and Enhance Cellular Uptake (2019)
- ChemBioChem
- Noninvasive and Quantitative Monitoring of the Distributions and Kinetics of MicroRNA-Targeting Molecules in Vivo by Positron Emission Tomography (2019)
- Molecular Pharmaceutics
- Oxazinomycin arrests RNA polymerase at the polythymidine sequences (2019)
- Nucleic Acids Research
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