Pasi Virta
Professor
pamavi@utu.fi +358 29 450 3209 +358 50 328 5719 |
Synthesis of oligonucleotide, peptide nucleic acid, peptide (including antibodies) and carbohydrate conjugates, Drug delivery strategies of oligonucleotides, mechanistic studies of higher order secondary structures of nucleic acids, 19F NMR spectroscopy, DNA-templated synthesis, aqueous glycosylation
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- DNA-Templated Formation and N,O-Transacetalization of N-MethoxyoxazolidinesCovalently Mercurated Molecular Beacon for Discriminating the Canonical Nucleobases (2022)
- European Journal of Organic ChemistryChemBioChem
- N-Methoxy-1,3-oxazinane nucleic acids (MOANAs) - a configurationally flexible backbone modification allows post-synthetic incorporation of base moietiesDrug-to-Antibody Ratio Estimation via Proteoform Peak Integration in the Analysis of Antibody-Oligonucleotide Conjugates with Orbitrap Fourier Transform Mass Spectrometry (2022)
- Organic and Biomolecular ChemistryAnalytical Chemistry
- O-59 - Radiolabeling and biological evaluation of functionalized spherical nucleic acids (2022)
- Nuclear Medicine and Biology
- Synthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules (2022)
- ACS Omega
- The DNA polymerase of bacteriophage YerA41 replicates its T-modified DNA in a primer-independent manner (2022)
- Nucleic Acids Research
- The role of the maleimide ring system on the structure-activity relationship of showdomycinSynthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support (2022)
- European Journal of Medicinal ChemistryRSC Advances
- Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core (2021)
- Bioconjugate Chemistry
- (2021)
- (2021)
- Expanding the Scope of the Cleavable N-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates (2021)
- MoleculesCurrent Protocols in Nucleic Acid Chemistry
- More versatile synthesis of oligonucleotidesPDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity (2021)
- Science
- Stability of the Phosphotriester PDE6D Inhibitors (2021)
- ChemistrySelect
- Site-Specific Linking of an Oligonucleotide to Mono- and Bivalent Recombinant Antibodies with SpyCatcher-SpyTag System for Immuno-PCR (2021)
- The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases (2021)
- Nature Communications
- Conjugation of Oligonucleotides to Peptide Aldehydes via a pH-Responsive N-Methoxyoxazolidine Linker (2020)
- Organic Letters
- Immobilized Carbohydrates for Preparation of 3'-Glycoconjugated Oligonucleotides (2020)
- (2020)
- ACS Omega
- (2020)
- ACS Omega
- 3-Fluoro-2-mercuri-6-methylaniline Nucleotide as a High-Affinity Nucleobase-Specific Hybridization Probe (2019)
- Bioconjugate Chemistry
- Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
- Scientific Reports
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