Sakari Hietanen

- Docent,
Faculty of Medicine (University of Turku)
- ,
Obstetrics and Gynaecology (Department of Clinical Medicine)

sakari.hietanen@utu.fi

1 of 4

Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer (2026)
- Cancer Research
Pradhan, Barun; Oikkonen, Jaana; Zhang, Kaiyang; Botto, Juan Manuel.; Eriksson, Minna R.; Sundaresan, Srividhya; Genç, Fatih; Pisanic, Thomas R.; Marin Falco, Matias; Li, Yilin; Pikkusaari, Sanna; Lavikka, Kari; Micoli, Giulia; Marchi, Giovanni; Muranen, Taru A.; Huhtinen, Kaisa; Vähärautio, Anna; Badge, Richard; Burns, Kathleen H.; Hietanen, Sakari; Hynninen, Johanna; Faulkner, Geoffrey J.; Hautaniemi, Sampsa; Kauppi, Liisa
Exploring survival-associated transcriptomic subtypes in ovarian cancer using RNAseq from FFPE tissues in a clinical trial cohort (2026)
- Translational Oncology
Kjeldsen, Maj K.; Bagger, Frederik Otzen; Roed, Henrik; Nyvang, Gitte-Bettina; Haslund, Charlotte Aaquist; Knudsen, Anja Oer; Motavaf, Anne Krejbjerg; Malander, Susanne; Anttila, Maarit; Lindahl, Gabriel; Maenpää, Johanna; Dimoula, Maria; Werner, Theresa; Iversen, Trine Zeeberg; Hietanen, Sakari; Fokdal, Lars; Dahlstrand, Hanna; Bjorge, Line; Birrer, Michael; Mirza, Mansoor Raza; Rossing, Maria
Pembrolizumab plus weekly paclitaxel in platinum-resistant recurrent ovarian cancer (ENGOT-ov65/KEYNOTE-B96): a multicentre, randomised, double-blind, phase 3 study (2026)
- Lancet
Colombo, Nicoletta; Zsiros, Emese; Parma, Gabriella; Rulli, Eliana; Sebastianelli, Alexandra; Bidzinski, Mariusz; Gallardo, Carlos; Matanes, Emad; Hasegawa, Kosei; Kose, Fatih; Magallanes-Maciel, Manuel; Herbertson, Rebecca A.; Ananda, Sumitra; Kroep, Judith R.; de Melo, Andreia Cristina; Debruyne, Philip R.; Kim, Jae-Weon; Sehouli, Jalid; Pierre, Marc-Edy; Hietanen, Sakari; Zamagni, Claudio; Lu, Xin; Monk, Bradley J.; Coleman, Robert L.; Peng, Xuan; Yamada, Karin; Bogusz, Agata M.; De La Motte Rouge, Thibault; Wu, Xiaohua; ENGOT-ov65/KEYNOTE-B96 investigators
Decoding the Genomic and Functional Landscape of Emerging Subtypes in Ovarian Cancer (2025)
- Cancer Discovery
Micoli, Giulia; Lavikka, Kari; Li, Yilin; Pirttikoski, Anna; Afenteva, Daria; Senkowski, Wojciech; Marchi, Giovanni; Vähärautio, Anna; Muranen, Taru A.; Joutsiniemi, Titta; Hietanen, Sakari; Virtanen, Anni; Wennerberg, Krister; Hynninen, Johanna; Oikkonen, Jaana; Hautaniemi, Sampsa
Genetic predictors of unexpected recurrence in low-risk endometrial cancer: A comprehensive genomic analysis reveals FGFR2 as a risk factor and a rare fatal POLE-mutated recurrence (2025)
- Gynecologic Oncology
Mettälä, Tuukka; Joutsiniemi, Titta; Huvila, Jutta; Hietanen, Sakari
Geneva Homologous Recombination Deficiency Test Is Predictive of Survival Benefit From Olaparib and Bevacizumab Maintenance in Ovarian Cancer (2025)
- JCO Precision Oncology
Christinat, Yann; Labidi-Galy, Intidhar; Ho, Liza; Clement, Sophie; Genestie, Catherine; Sehouli, Jalid; Cinieri, Saverio; Gonzalez-Martin, Antonio; Kolovetsiou-Kreiner, Vassiliki; Fujiwara, Keiichi; Von Gorp, Toon; Tognon, Germana; Hietanen, Sakari; Heinzelmann-Schwarz, Viola; Ray-Coquard, Isabelle; Pujade-Lauraine, Eric; Mckee, Thomas A.
HR-SC—an academic-developed machine learning framework to classify HRD-positive ovarian cancer patients and predict sensitivity to olaparib. (2025)
- ESMO Open
Beltrame, L.; Mannarino, L.; Sergi, A.; Velle, A.; Treilleux, I.; Pignata, S.; Paracchini, L.; Harter, P.; Scambia, G.; Perrone, F.; González-Martin, A.; Berger, R.; Arenare, L.; Hietanen, S.; Califano, D.; Derio, S.; Van Gorp, T.; Dalessandro, M.L.; Fujiwara, K.; Provansal, M.; Lorusso, D.; Buderath, P.; Masseroli, M.; Ray-Coquard, I.; Pujade-Lauraine, E.; Romualdi, C.; D’Incalci, M.; Marchini S.
Multi-omics analysis reveals the attenuation of the interferon pathway as a driver of chemo-refractory ovarian cancer (2025)
- Cell Reports Medicine
Afenteva, Daria; Yu, Rong; Rajavuori, Anna; Salvadores, Marina; Launonen, Inga-Maria; Lavikka, Kari; Zhang, Kaiyang; Pirttikoski, Anna; Marchi, Giovanni; Jamalzadeh, Sanaz; Isoviita, Veli-Matti; Li, Yilin; Micoli, Giulia; Erkan, Erdogan Pekcan; Falco, Matias M.; Ungureanu, Daniela; Lahtinen, Alexandra; Oikkonen, Jaana; Hietanen, Sakari; Vähärautio, Anna; Sur, Inderpreet; Virtanen, Anni; Färkkilä, Anniina; Hynninen, Johanna; Muranen, Taru A.; Taipale, Jussi; Hautaniemi, Sampsa
Predictive value of BRCA1/RAD51C methylation in HGSOC – An ancillary study of the PAOLA-1/ENGOT-ov25 phase 3 trial (2025)
- European Journal of Cancer
Blons, H.; Abdelli, J.; Landman, S.; Taly, V.; Mulot, C.; Laurent-Puig, P.; You, B.; Harter, P.; Lorusso, D.; García-García, Y.; Polterauer, S.; Hietanen, S.; Colombo, N.; Vergote, I.; Kobayashi, H.; De La Motte Rouge, T.; Buderath, P.; Cecere, S.C.; Bataillon, G.; Pujade-Lauraine, E.; Ray-Coquard, I.
Beyond HRD status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer (2024)
- Cancer Research Communications
Kjeldsen, Maj K.; Jørgensen, Morten; Grønseth, Dina Sofie B.; Schønemann-Lund, Martin; Nyvang, Gitte-Bettina; Haslund, Charlotte Aaquist; Knudsen, Anja Oer; Motavaf, Anne Krejbjerg; Malander, Susanne; Anttila, Maarit; Lindahl, Gabriel; Mäenpää, Johanna; Dimoula, Maria; Werner, Theresa L; Iversen, Trine Zeeberg; Hietanen, Sakari; Fokdal, Lars; Dahlstrand, Hanna; Bjorge, Line; Birrer, Michael J.; Mirza, Mansoor R.; Rossing, Maria
Deciphering cancer genomes with GenomeSpy : a grammar-based visualization toolkit (2024)
- GigaScience
Lavikka, Kari; Oikkonen, Jaana; Li, Yilin; Muranen, Taru; Micoli, Giulia; Marchi, Giovanni; Lahtinen, Alexandra; Huhtinen, Kaisa; Lehtonen, Rainer; Hietanen, Sakari; Hynninen, Johanna; Virtanen, Anni; Hautaniemi, Sampsa
Efficacy and safety of niraparib in patients aged 65 years and older with advanced ovarian cancer : Results from the PRIMA/ENGOT-OV26/GOG-3012 trial (2024)
- Gynecologic Oncology
Valabrega, Giorgio; Pothuri, Bhavana; Oaknin, Ana; Graybill, Whitney S.; Sánchez, Ana Beatriz; McCormick, Colleen; Baurain, Jean-François; Tinker, Anna V.; Denys, Hannelore; O’Cearbhaill, Roisin E.; Hietanen, Sakari; Moore, Richard G.; Knudsen, Anja Ør; de La Motte Rouge, Thibault; Heitz, Florian; Levy, Tally; York, Whitney; Gupta, Divya; Monk, Bradley J.; González-Martín, Antonio
Extensive mutational ctDNA profiles reflect High-grade serous cancer tumors and reveal emerging mutations at recurrence (2024)
- Translational Oncology
Marchi, Giovanni; Rajavuori, Anna; Nguyen, Mai T. N.; Huhtinen, Kaisa; Oksa, Sinikka; Hietanen, Sakari; Hautaniemi, Sampsa; Hynninen, Johanna; Oikkonen, Jaana
Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma (2024)
- BMC Cancer
Jamalzadeh, Sanaz; Dai, Jun; Lavikka, Kari; Li, Yilin; Jiang, Jing; Huhtinen, Kaisa; Virtanen, Anni; Oikkonen, Jaana; Hietanen, Sakari; Hynninen, Johanna; Vähärautio, Anna; Häkkinen, Antti; Hautaniemi, Sampsa
HRD related signature 3 predicts clinical outcome in advanced tubo-ovarian high-grade serous carcinoma (2024)
- Gynecologic Oncology
Koskela, Heidi; Li, Yilin; Joutsiniemi, Titta; Muranen, Taru; Isoviita, Veli-Matti; Huhtinen, Kaisa; Micoli, Giulia; Lavikka, Kari; Marchi, Giovanni; Hietanen, Sakari; Virtanen, Anni; Hautaniemi, Sampsa; Oikkonen, Jaana; Hynninen, Johanna
Is it safe to operate selected low-risk endometrial cancer patients in secondary hospitals? (2024)
- EJSO - European Journal of Surgical Oncology
Narva, Sara; Polo-Kantola, Päivi; Oksa, Sinikka; Kallio, Johanna; Huvila, Jutta; Rissanen, Tiia; Hynninen, Johanna; Hietanen, Sakari; Joutsiniemi, Titta
Olaparib Addition to Maintenance Bevacizumab Therapy in Ovarian Carcinoma With BRCA-Like Genomic Aberrations (2024)
- JAMA Network Open
Schouten, Philip C.; Schmidt, Sandra; Becker, Kerstin; Thiele, Holger; Nürnberg, Peter; Richters, Lisa; Ernst, Corinna; Treilleux, Isabelle; Medioni, Jacques; Heitz, Florian; Pisano, Carmela; Garcia, Yolanda; Petru, Edgar; Hietanen, Sakari; Colombo, Nicoletta; Vergote, Ignace; Nagao, Shoji; Linn, Sabine C.; Pujade-Lauraine, Eric; Ray-Coquard, Isabelle; Harter, Philipp; Hahnen, Eric; Schmutzler, Rita K.
Patient-reported outcomes in the subpopulation of patients with mismatch repair-deficient/microsatellite instability-high primary advanced or recurrent endometrial cancer treated with dostarlimab plus chemotherapy compared with chemotherapy alone in the ENGOT-EN6-NSGO/GOG3031/RUBY trial (2024)
- International Journal of Gynecological Cancer
Valabrega, Giorgio; Powell, Matthew A.; Hietanen, Sakari; Miller, Eirwen M.; Novak, Zoltan; Holloway, Robert; Denschlag, Dominik; Myers, Tashanna; Thijs, Anna M.; Pennington, Kathryn P.; Gilbert, Lucy; Fleming, Evelyn; Zub, Oleksandr; Landrum, Lisa M.; Ataseven, Beyhan; Gogoi, Radhika; Podzielinski, Iwona; Cloven, Noelle; Monk, Bradley J.; Sharma, Sudarshan; Herzog, Thomas J.; Stuckey, Ashley; Pothuri, Bhavana; Secord, Angeles Alvarez; Chase, Dana; Vincent, Veena; Meyers, Oren; Garside, Jamie; Mirza, Mansoor Raza; Black, Destin
Pembrolizumab or Placebo Plus Adjuvant Chemotherapy With or Without Radiotherapy For Newly Diagnosed, High-Risk Endometrial Cancer: Results in Mismatch Repair-Deficient Tumors (2024)
- Journal of Clinical Oncology
Slomovitz, Brian M.; Cibula, David; Lv, Weiguo; Ortaç, Fırat; Hietanen, Sakari; Backes, Floor; Kikuchi, Akira; Lorusso, Domenica; Dańska-Bidzińska, Anna; Samouëlian, Vanessa; Barretina-Ginesta, Maria-Pilar; Vulsteke, Christof; Lai, Chyong-Huey; Pothuri, Bhavana; Zhang, Yu; Magallanes-Maciel, Manuel; Amit, Amnon; Guarneri, Valentina; Zagouri, Flora; Bell, Maria; Welz, Julia; Eminowicz, Gemma; Hruda, Martin; Willmott, Lyndsay J.; Lichfield, Jasmine; Wang, Wei; Orlowski, Robert; Aktan, Gursel; Gladieff, Laurence; Van Gorp, Toon
Prognostic factors and overall survival among patients with ovarian cancer in the pre-PARP inhibitor era: the OCRWE-Finland study (2024)
- Acta Oncologica
Lahelma, Mari; Rauhamaa, Heini; Leskelä, Riikka-Leena; Isomeri, Outi; Idänpään-Heikkilä, Juhana; Käkelä, Sari; Roebuck, Nichola; Mascialino, Barbara; Hietanen, Sakari; Loukovaara, Mikko; Auranen, Annika