Sakari Hietanen

- Docent,
Faculty of Medicine (University of Turku)
- ,
Obstetrics and Gynaecology (Department of Clinical Medicine)

sakari.hietanen@utu.fi

Publications

1 of 4

Genetic predictors of unexpected recurrence in low-risk endometrial cancer: A comprehensive genomic analysis reveals FGFR2 as a risk factor and a rare fatal POLE-mutated recurrencePembrolizumab or Placebo Plus Adjuvant Chemotherapy With or Without Radiotherapy For Newly Diagnosed, High-Risk Endometrial Cancer: Results in Mismatch Repair-Deficient Tumors (2025)
- Gynecologic OncologyJournal of Clinical Oncology
Mettälä, Tuukka; Joutsiniemi, Titta; Huvila, Jutta; Hietanen, Sakari
(A1 Refereed original research article in a scientific journal)
HR-SC—an academic-developed machine learning framework to classify HRD-positive ovarian cancer patients and predict sensitivity to olaparib. (2025)
- ESMO OpenJAMA Network Open
Beltrame, L.; Mannarino, L.; Sergi, A.; Velle, A.; Treilleux, I.; Pignata, S.; Paracchini, L.; Harter, P.; Scambia, G.; Perrone, F.; González-Martin, A.; Berger, R.; Arenare, L.; Hietanen, S.; Califano, D.; Derio, S.; Van Gorp, T.; Dalessandro, M.L.; Fujiwara, K.; Provansal, M.; Lorusso, D.; Buderath, P.; Masseroli, M.; Ray-Coquard, I.; Pujade-Lauraine, E.; Romualdi, C.; D’Incalci, M.; Marchini S.
(A1 Refereed original research article in a scientific journal)
Beyond HRD status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer (2024)
- Cancer Research Communications
Kjeldsen, Maj K.; Jørgensen, Morten; Grønseth, Dina Sofie B.; Schønemann-Lund, Martin; Nyvang, Gitte-Bettina; Haslund, Charlotte Aaquist; Knudsen, Anja Oer; Motavaf, Anne Krejbjerg; Malander, Susanne; Anttila, Maarit; Lindahl, Gabriel; Mäenpää, Johanna; Dimoula, Maria; Werner, Theresa L; Iversen, Trine Zeeberg; Hietanen, Sakari; Fokdal, Lars; Dahlstrand, Hanna; Bjorge, Line; Birrer, Michael J.; Mirza, Mansoor R.; Rossing, Maria
(A1 Refereed original research article in a scientific journal)
Deciphering cancer genomes with GenomeSpy : a grammar-based visualization toolkitComorbidity of Urogynecological and Gastrointestinal Disorders in Female Patients With Lichen Sclerosus (2024)
- GigaScience
Lavikka, Kari; Oikkonen, Jaana; Li, Yilin; Muranen, Taru; Micoli, Giulia; Marchi, Giovanni; Lahtinen, Alexandra; Huhtinen, Kaisa; Lehtonen, Rainer; Hietanen, Sakari; Hynninen, Johanna; Virtanen, Anni; Hautaniemi, Sampsa
(A1 Refereed original research article in a scientific journal)
Efficacy and safety of niraparib in patients aged 65 years and older with advanced ovarian cancer : Results from the PRIMA/ENGOT-OV26/GOG-3012 trialReal-life treatment patterns and time to next treatment among patients with ovarian cancer in the pre-PARP inhibitor era: the OCRWE-Finland Study (2024)
- Gynecologic OncologyActa Oncologica
Valabrega, Giorgio; Pothuri, Bhavana; Oaknin, Ana; Graybill, Whitney S.; Sánchez, Ana Beatriz; McCormick, Colleen; Baurain, Jean-François; Tinker, Anna V.; Denys, Hannelore; O’Cearbhaill, Roisin E.; Hietanen, Sakari; Moore, Richard G.; Knudsen, Anja Ør; de La Motte Rouge, Thibault; Heitz, Florian; Levy, Tally; York, Whitney; Gupta, Divya; Monk, Bradley J.; González-Martín, Antonio
(A1 Refereed original research article in a scientific journal)
Extensive mutational ctDNA profiles reflect High-grade serous cancer tumors and reveal emerging mutations at recurrenceCirculating tumor DNA-based copy-number profiles enable monitoring treatment effects during therapy in high-grade serous carcinoma (2024)
- Translational Oncology
Marchi Giovanni, Rajavuori Anna, Nguyen Mai T. N., Huhtinen Kaisa, Oksa Sinikka, Hietanen Sakari, Hautaniemi Sampsa, Hynninen Johanna, Oikkonen Jaana
(A1 Refereed original research article in a scientific journal)
Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma (2024)
- BMC CancerCancer Cell
Jamalzadeh Sanaz, Dai Jun, Lavikka Kari, Li Yilin, Jiang Jing, Huhtinen Kaisa, Virtanen Anni, Oikkonen Jaana, Hietanen Sakari, Hynninen Johanna, Vähärautio Anna, Häkkinen Antti, Hautaniemi Sampsa
(A1 Refereed original research article in a scientific journal)
HRD related signature 3 predicts clinical outcome in advanced tubo-ovarian high-grade serous carcinoma (2024)
- Gynecologic OncologyJournal of Lower Genital Tract DiseaseInternational Journal of Gynecological Cancer
Koskela Heidi, Li Yilin, Joutsiniemi Titta, Muranen Taru, Isoviita Veli-Matti, Huhtinen Kaisa, Micoli Giulia, Lavikka Kari, Marchi Giovanni, Hietanen Sakari, Virtanen Anni, Hautaniemi Sampsa, Oikkonen Jaana, Hynninen Johanna
(A1 Refereed original research article in a scientific journal)
Is it safe to operate selected low-risk endometrial cancer patients in secondary hospitals?Efficacy and safety of maintenance olaparib and bevacizumab in ovarian cancer patients aged ≥65 years from the PAOLA-1/ENGOT-ov25 trial (2024)
- EJSO - European Journal of Surgical OncologyEuropean Journal of Cancer
Narva Sara, Polo-Kantola Päivi, Oksa Sinikka, Kallio Johanna, Huvila Jutta, Rissanen Tiia, Hynninen Johanna, Hietanen Sakari, Joutsiniemi Titta
(A1 Refereed original research article in a scientific journal)
Olaparib Addition to Maintenance Bevacizumab Therapy in Ovarian Carcinoma With BRCA-Like Genomic Aberrations (2024)
Schouten Philip C., Schmidt Sandra, Becker Kerstin, Thiele Holger, Nürnberg Peter, Richters Lisa, Ernst Corinna, Treilleux Isabelle, Medioni Jacques, Heitz Florian, Pisano Carmela, Garcia Yolanda, Petru Edgar, Hietanen Sakari, Colombo Nicoletta, Vergote Ignace, Nagao Shoji, Linn Sabine C., Pujade-Lauraine Eric, Ray-Coquard Isabelle, Harter Philipp, Hahnen Eric, Schmutzler Rita K.
(A1 Refereed original research article in a scientific journal)
Patient-reported outcomes in the subpopulation of patients with mismatch repair-deficient/microsatellite instability-high primary advanced or recurrent endometrial cancer treated with dostarlimab plus chemotherapy compared with chemotherapy alone in the ENGOT-EN6-NSGO/GOG3031/RUBY trial (2024)
- International Journal of Gynecological Cancer
Valabrega, Giorgio; Powell, Matthew A.; Hietanen, Sakari; Miller, Eirwen M.; Novak, Zoltan; Holloway, Robert; Denschlag, Dominik; Myers, Tashanna; Thijs, Anna M.; Pennington, Kathryn P.; Gilbert, Lucy; Fleming, Evelyn; Zub, Oleksandr; Landrum, Lisa M.; Ataseven, Beyhan; Gogoi, Radhika; Podzielinski, Iwona; Cloven, Noelle; Monk, Bradley J.; Sharma, Sudarshan; Herzog, Thomas J.; Stuckey, Ashley; Pothuri, Bhavana; Secord, Angeles Alvarez; Chase, Dana; Vincent, Veena; Meyers, Oren; Garside, Jamie; Mirza, Mansoor Raza; Black, Destin
(A1 Refereed original research article in a scientific journal)
(2024)
Slomovitz, Brian M.; Cibula, David; Lv, Weiguo; Ortaç, Fırat; Hietanen, Sakari; Backes, Floor; Kikuchi, Akira; Lorusso, Domenica; Dańska-Bidzińska, Anna; Samouëlian, Vanessa; Barretina-Ginesta, Maria-Pilar; Vulsteke, Christof; Lai, Chyong-Huey; Pothuri, Bhavana; Zhang, Yu; Magallanes-Maciel, Manuel; Amit, Amnon; Guarneri, Valentina; Zagouri, Flora; Bell, Maria; Welz, Julia; Eminowicz, Gemma; Hruda, Martin; Willmott, Lyndsay J.; Lichfield, Jasmine; Wang, Wei; Orlowski, Robert; Aktan, Gursel; Gladieff, Laurence; Van Gorp, Toon
(A1 Refereed original research article in a scientific journal)
Prognostic factors and overall survival among patients with ovarian cancer in the pre-PARP inhibitor era: the OCRWE-Finland study (2024)
- Acta Oncologica
Lahelma, Mari; Rauhamaa, Heini; Leskelä, Riikka-Leena; Isomeri, Outi; Idänpään-Heikkilä, Juhana; Käkelä, Sari; Roebuck, Nichola; Mascialino, Barbara; Hietanen, Sakari; Loukovaara, Mikko; Auranen, Annika
(A1 Refereed original research article in a scientific journal)
(2024)
Lahelma, Mari; Rauhamaa, Heini; Isomeri, Outi; Idänpään-Heikkilä, Juhana; Käkelä, Sari; Roebuck, Nichola; Mascialino, Barbara; Hietanen, Sakari; Loukovaara, Mikko; Auranen, Annika
(A1 Refereed original research article in a scientific journal)
(2023)
- Biomedicine and Pharmacotherapy
Nguyen Mai TN, Rajavuori Anna, Huhtinen Kaisa, Hietanen Sakari, Hynninen Johanna, Oikkonen Jaana, Hautaniemi Sampsa
(A1 Refereed original research article in a scientific journal)
(2023)
Söderlund Jenni M, Hieta Niina K, Kurki Samu H, Orte Katri J, Polo-Kantola Päivi, Hietanen Sakari H, Haataja Marjut AM
(A1 Refereed original research article in a scientific journal)
2023
Sabatier Renaud, Rousseau Frédérique, Joly Florence, Cropet Claire, Montégut Coline, Frindte Johanna, Cinieri Saverio, Guerra Alía Eva M, Polterauer Stephan, Yoshida Hiroyuki, Vergote Ignace, Colombo Nicoletta, Hietanen Sakari, Largillier Rémi, Canzler Ulrich, Gratet Alain, Marmé Frederick, Favier Laure, Pujade-Lauraine Eric, Ray-Coquard Isabelle
(A1 Refereed original research article in a scientific journal)
Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma (2023)
Lahtinen Alexandra, Lavikka Kari, Virtanen Anni, Li Yilin, Jamalzadeh Sanaz, Skorda Aikaterini, Lauridsen Anna Rössberg, Zhang Kaiynag, Marchi Giovanni, Isoviita Veli-Matti, Ariotta Valeria, Lehtonen Oskari, Muranen Taru A., Huhtinen Kaisa, Carpén Olli, Hietanen Sakari, Senkowski Wojciech, Kallunki Tuula, Häkkinen Aantti, Hynninen Johanna, Oikkonen Jaana, Hautaniemi Sampsa
(A1 Refereed original research article in a scientific journal)
Evolutionary study identifies poor prognosis HGSC patients and reveals clinically relevant targets at diagnosis and relapse (2023)
Oikkonen, Jaana; Lahtinen, Alexandra; Lavikka, Kari; Virtanen, Anni; Li, Yilin; Jamalzadeh, Sanaz; Skorda, Aikaterini; Lauridsen, Anna Rossberg; Zhang, Kaiyang; Marchi, Giovanni; Nguyen, Mai T. N.; Rajavuori, Anna; Muranen, Taru A.; Huhtinen, Kaisa; Hietanen, Sakari; Senkowski, Wojciech; Kallunki, Tuula; Hakkinen, Antti; Hynninen, Johanna; Hautaniemi, Sampsa
(Other publication)
Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes (2023)
- Clinical Cancer Research
Pikkusaari Sanna, Tumiati Manuela, Virtanen Anni, Oikkonen Jaana, Li Yilin, Perez-Villatoro Fernando, Muranen Taru, Salko Matilda, Huhtinen Kaisa, Kanerva Anna, Koskela Heidi, Tapper Johanna, Koivisto-Korander Riitta, Joutsiniemi Titta, Haltia Ulla-Maija, Lassus Heini, Hautaniemi Sampsa, Färkkilä Anniina, Hynninen Johanna, Hietanen Sakari, Carpen Olli, Kauppi Liisa
(A1 Refereed original research article in a scientific journal)