A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity



Tekijät: Lamichhane, Santosh; Dickens, Alex M.; Buchacher, Tanja; Lou, Tianai; Charron-Lamoureux, Vincent; Kattelus, Roosa; Karmacharya, Pragya; Pinto da Silva, Lucas; Kråkström, Matilda; Rasool, Omid; Sen, Partho; Walker, Corinn; Patan, Abubaker; Gentry, Emily C.; Zuffa, Simone; Arzoomand, Aron; Lakshmikanth, Tadepally; Mikeš, Jaromir; Mebrahtu, Aman; Vatanen, Tommi; Raffatellu, Manuela; Zengler, Karsten; Hyötyläinen, Tuulia; Xavier, Ramnik J.; Brodin, Petter; Lahesmaa, Riitta; Dorrestein, Pieter C.; Knip, Mikael; Orešič, Matej

Kustantaja: Springer Nature

Julkaisuvuosi: 2026

Lehti: Nature Communications

Artikkelin numero: 38

Vuosikerta: 17

eISSN: 2041-1723

DOI: https://doi.org/10.1038/s41467-025-66619-6

Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla

Julkaisukanavan avoimuus : Kokonaan avoin julkaisukanava

Verkko-osoite: https://doi.org/10.1038/s41467-025-66619-6

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/505811785


Tiivistelmä

Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health effects remain unclear. Here, we analyzed early-life microbially conjugated bile acid patterns and their link to islet autoimmunity. We quantified 110 microbial bile acids in 303 stool samples collected longitudinally (3–36 months) from children who developed one or more islet autoantibodies and controls who remained autoantibody-negative. We identified distinct age-dependent trajectories of these bile acid amidates and correlated them with gut microbiome composition. We found that altered levels of ursodeoxycholic and deoxycholic acid conjugates were linked to islet autoimmunity as well as modulated monocyte activation in response to immunostimulatory lipopolysaccharide and Th17/Treg cell balance. These findings suggest that microbially conjugated bile acids influence immune development and type 1 diabetes risk


Ladattava julkaisu

This is an electronic reprint of the original article.
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Julkaisussa olevat rahoitustiedot: 
Open access funding provided by Örebro University.


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