Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention (2016)
- Journal of Nutrition
- Assessment of blood biomarkers of mild traumatic brain injury in professional rugby; a case control study (2016)
- Brain Injury
- Bioanalytical techniques in nontargeted clinical lipidomics (2016)
- Bioanalysis
- Data standards can boost metabolomics research, and if there is a will, there is a way (2016)
- Metabolomics
- Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease (2016)
- Nature Communications
- Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease (2016)
- Journal of Hepatology
- Human gut microbes impact host serum metabolome and insulin sensitivity (2016)
- Nature
- Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI) (2016)
- Metabolism
- Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism (2016)
- Journal of Lipid Research
- Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites (2016)
- Journal of Nutritional Biochemistry
- Modeling strategies to study metabolic pathways in progression to type 1 diabetes - Challenges and opportunities (2016)
- Archives of Biochemistry and Biophysics
- Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites (2016)
- Clinical Gastroenterology and Hepatology
- Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016)
- Scientific Reports
- Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis (2016)
- Translational Psychiatry
- The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes (vol 17, pg 260, 2015) (2016)
- Cell Host and Microbe
- The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans (2016)
- Journal of Hepatology
- Altered lipid metabolism preceding onset of islet autoimmunity and type 1 diabetes (2015)
- Diabetologia
- Analytical Lipidomics in Metabolic and Clinical Research (2015)
- Trends in Endocrinology and Metabolism
- Bioactive lipids dissociate steatosis and insulin resistance in the human liver in non-alcoholic fatty liver disease (2015)
- Diabetologia
- Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2 (2015)
- Journal of Hepatology