Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP) (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe (2018)
- Methods
(A1 Refereed original research article in a scientific journal) - Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men (2018)
- Metabolism
(A1 Refereed original research article in a scientific journal) - MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines (2018)
- Journal of Lipid Research
(A1 Refereed original research article in a scientific journal) - Perspectives on systems modeling of human peripheral blood mononuclear cells (2018)
- Frontiers in Molecular Biosciences
(A2 Refereed review article in a scientific journal ) - Platform for systems medicine research and diagnostic applications in psychotic disorders-The METSY project (2018)
- European Psychiatry
(A2 Refereed review article in a scientific journal ) - Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars (2018)
- Diabetes Care
(A1 Refereed original research article in a scientific journal) - Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain Injury (2018)
- Journal of Neurotrauma
(A1 Refereed original research article in a scientific journal) - Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes (2018)
- Pediatric Research
(A1 Refereed original research article in a scientific journal) - Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor (2018)
- Frontiers in Neuroscience
Hilkka Soininen, Tuulia Hyötyläinen, Cherlynn Basignani
(A1 Refereed original research article in a scientific journal) - Use of Blood Biomarkers in the Assessment of Sports-Related Concussion-A Systematic Review in the Context of Their Biological Significance (2018)
- Clinical Journal of Sport Medicine
(A2 Refereed review article in a scientific journal ) - Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma (2017)
- Journal of Lipid Research
(A1 Refereed original research article in a scientific journal) - Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance (2017)
- Cell Metabolism
(A1 Refereed original research article in a scientific journal) - Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (2017)
- Translational Psychiatry
(A1 Refereed original research article in a scientific journal) - Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD (2017)
- Journal of Hepatology
(A1 Refereed original research article in a scientific journal) - Lipidomics in biomedical research-practical considerations (2017)
- Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
(A1 Refereed original research article in a scientific journal) - Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study (2017)
- Pediatric Diabetes
(A1 Refereed original research article in a scientific journal) - Metabolomics profiling as a diagnostic tool in severe traumatic brain injury (2017)
- Frontiers in Neurology
(A2 Refereed review article in a scientific journal ) - PPAR gamma Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium (2017)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases (2017)
- Progress in Lipid Research
(B1 Non-refereed article in a scientific journal)