Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- Technological readiness and implementation of genomic-driven precision medicine for complex diseases (2021)
- Journal of Internal Medicine
(A2 Refereed review article in a scientific journal ) - 4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters (2020)
- Frontiers in Pharmacology
(A1 Refereed original research article in a scientific journal) - Building an international consortium for tracking coronavirus health status (2020)
- Nature Medicine
(B1 Non-refereed article in a scientific journal) - Correction: Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state (2020)
- Journal of Biological Chemistry
(Other publication) - Double Derivatization Strategy for High-Sensitivity and High- Coverage Localization of Double Bonds in Free Fatty Acids by Mass Spectrometry (2020)
- Analytical Chemistry
(A1 Refereed original research article in a scientific journal) - Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease (2020)
- Environmental Research
(A1 Refereed original research article in a scientific journal) - Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease (2020)
- JCI Insight
(A1 Refereed original research article in a scientific journal) - Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury (2020)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis (2020)
- NPJ Schizophrenia
(A1 Refereed original research article in a scientific journal) - MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans (2020)
- Journal of Hepatology
(B1 Non-refereed article in a scientific journal) - Metabolic alterations in immune cells associate with progression to type 1 diabetes (2020)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Metabolic Signatures of the Exposome-Quantifying the Impact of Exposure to Environmental Chemicals on Human Health (2020)
- Metabolites
(A2 Refereed review article in a scientific journal ) - Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes (2020)
- Environment International
(A1 Refereed original research article in a scientific journal) - Publisher Correction: Building an international consortium for tracking coronavirus health status (2020)
- Nature Medicine
(Other publication) - The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue (2020)
- Liver International
(A1 Refereed original research article in a scientific journal) - Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis (2020)
- Science Translational Medicine
(A1 Refereed original research article in a scientific journal) - Circulating metabolites in progression to islet autoimmunity and type 1 diabetes (2019)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes (2019)
- Biomolecules
(A1 Refereed original research article in a scientific journal) - Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease (2019)
- Cell
(A1 Refereed original research article in a scientific journal) - Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo (2019)
- Ecotoxicology and Environmental Safety
(A1 Refereed original research article in a scientific journal)



