Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- (2020)
- Nature Medicine
(Other publication) - The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue (2020)
- Liver International
(A1 Refereed original research article in a scientific journal) - Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis (2020)
- Science Translational Medicine
(A1 Refereed original research article in a scientific journal) - Circulating metabolites in progression to islet autoimmunity and type 1 diabetes (2019)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes (2019)
- Biomolecules
(A1 Refereed original research article in a scientific journal) - Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease (2019)
- Cell
(A1 Refereed original research article in a scientific journal) - Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo (2019)
- Ecotoxicology and Environmental Safety
(A1 Refereed original research article in a scientific journal) - Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids (2019)
- JCI Insight
(A1 Refereed original research article in a scientific journal) - Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children (2019)
- Biological Psychiatry
(A1 Refereed original research article in a scientific journal) - Lipidomes in health and disease: Analytical strategies and considerations (2019)
- Trends in Analytical Chemistry
(A1 Refereed original research article in a scientific journal) - Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An Overview (2019)
- Metabolites
(A2 Refereed review article in a scientific journal ) - Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS) (2019)
- Metabolites
(A1 Refereed original research article in a scientific journal) - Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease (2019)
- Clinical and Translational Gastroenterology
(A1 Refereed original research article in a scientific journal) - Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry (2019)
- Analytical and Bioanalytical Chemistry
(A1 Refereed original research article in a scientific journal) - Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients (2019)
- Metabolites
(A1 Refereed original research article in a scientific journal) - The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies (2019)
- American Journal of Epidemiology
(A1 Refereed original research article in a scientific journal) - The Role of Omic Technologies in the Study of the Human Gut Microbiome (2019) Reference Module in Food Science Partho Sen, Santosh Lamichhane, Alex M Dickens, Matej Orešič
(A3 Refereed book chapter or chapter in a compilation book) - A computational framework to integrate high-throughput ‘-omics’ datasets for the identification of potential mechanistic links (2018)
- Nature Protocols
(A1 Refereed original research article in a scientific journal) - A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes (2018)
- Scientific Data
(A1 Refereed original research article in a scientific journal) - Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response (2018)
- Schizophrenia Research
(A1 Refereed original research article in a scientific journal)