Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- Liquid and gas-chromatography-mass spectrometry methods for exposome analysis (2025)
- Journal of Chromatography A
(A2 Refereed review article in a scientific journal ) - Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization (2024)
- Analytical Chemistry
(A1 Refereed original research article in a scientific journal) - Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards (2024)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity (2024)
- Environment International
(A1 Refereed original research article in a scientific journal) - Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis (2024)
- Cell Reports Medicine
(A1 Refereed original research article in a scientific journal) - Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease (2024)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases (2024)
- Environmental Science and Technology
(A1 Refereed original research article in a scientific journal) - Infant microbes and metabolites point to childhood neurodevelopmental disorders (2024)
- Cell
(A1 Refereed original research article in a scientific journal) - In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland : a cross-sectional study (2024)
- The Lancet Planetary Health
(A1 Refereed original research article in a scientific journal) - Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA (2024)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Refereed original research article in a scientific journal) - Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models (2024)
- Environment International
(A1 Refereed original research article in a scientific journal) - Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors (2024)
- Metabolomics
(A1 Refereed original research article in a scientific journal) - Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD) (2024)
- Pharmaceutics
(A1 Refereed original research article in a scientific journal) - Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases (2024)
- Journal of Exposure Science and Environmental Epidemiology
(A1 Refereed original research article in a scientific journal) - Reproducible mass spectrometry data processing and compound annotation in MZmine 3 (2024)
- Nature Protocols
(A1 Refereed original research article in a scientific journal) - Serum lipidome associates with neuroimaging features in patients with traumatic brain injury (2024)
- iScience
(A1 Refereed original research article in a scientific journal) - Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function (2023)
- Cardiovascular Research
(A1 Refereed original research article in a scientific journal) - CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells (2023)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children (2023)
- Frontiers in Endocrinology
(A1 Refereed original research article in a scientific journal) - Classification of Common Food Lipid Sources Regarding Healthiness Using Advanced Lipidomics: A Four-Arm Crossover Study (2023)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal)