A1 Refereed original research article in a scientific journal
Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases
Authors: Hyötyläinen Tuulia, Ghaffarzadegan Tannaz, Karthikeyan Bagavathy Shanmugam, Triplett Eric, Orešič Matej, Ludvigsson Johnny
Publisher: American Chemical Society
Publication year: 2024
Journal: Environmental Science and Technology
Journal name in source: ENVIRONMENTAL SCIENCE & TECHNOLOGY
Journal acronym: ENVIRON SCI TECHNOL
Volume: 58
Issue: 5
First page : 2214
Last page: 2223
Number of pages: 10
ISSN: 0013-936X
eISSN: 1520-5851
DOI: https://doi.org/10.1021/acs.est.3c06269
Web address : https://pubs.acs.org/doi/full/10.1021/acs.est.3c06269
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/387077238
The composition of human breast milk (HBM) exhibits significant variability both between individuals and within the same individual. While environmental factors are believed to play a role in this variation, their influence on breast milk composition remains inadequately understood. Herein, we investigate the impact of environmental factors on HBM lipid composition in a general population cohort. The study included mothers (All Babies In Southeast Sweden study) whose children later progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 9), celiac disease (n = 24), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), hypothyroidism (n = 6), and matched controls (n = 173). Lipidome of HBM was characterized by liquid chromatography combined with high-resolution mass spectrometry. We observed that maternal age, body mass index, diet, and exposure to perfluorinated alkyl substances (PFASs) had a marked impact on breast milk lipidome, with larger changes observed in the milk of those mothers whose children later developed autoimmune diseases. We also observed differences in breast milk lipid composition in those mothers whose offspring later developed autoimmune diseases. Our study suggests that breast milk lipid composition is modified by a complex interaction between genetic and environmental factors, and, importantly, this impact was significantly more pronounced in those mothers whose offspring later developed autoimmune/inflammatory diseases. Our findings also suggest that merely assessing PFAS concentration may not capture the full extent of the impact of chemical exposures; thus, the more comprehensive exposome approach is essential for accurately assessing the impact of PFAS exposure on HBM and, consequently, on the health outcomes of the offspring.
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