Pekka Patrikainen
PhD
Synthetic Biology, Synechocystis, Metabolic Engineering, Molecular Biology, Enzymology, Natural Product Biosynthesis
My research focuses on the metabolic engineering of cyanobacteria to enable their use as biotechnological host for production of variety of chemicals. Another focus area is the development of genetic tools which are required for efficient and predictable modification of these photosynthetic organisms. My research involves the use of molecular biology, microbiology and different analytical methods.
More information can be found from the website of our research group at https://utu.fi/sbc
- CyanoConstruct: simple platform for cyanobacterial expression construct assembly and translational tuning (2026)
- BMC Biotechnology
- Redirecting photosynthetic electron flux in the cyanobacterium Synechocystis sp. PCC 6803 by the deletion of flavodiiron protein Flv3 (2019)
- Microbial Cell Factories
- Comparison of orthologous cyanobacterial aldehyde deformylating oxygenases in the production of volatile C3-C7 alkanes in engineered E. coli (2017)
- Metabolic Engineering Communications
- Engineering the cyanobacterium synechocystis Sp. PCC 6803 towards optimized solutions for future biotechnological applications (2017) Nagy C., Aro E., Kallio P., Patrikainen P., Thiel K., Dandapani H., Mulaku E., Kakko L.
- Structural and functional Studies of angucycline tailoring enzymes (2015) Patrikainen Pekka
- Structure-Based Engineering of Angucyclinone 6-Ketoreductases. (2014)
- Chemistry and Biology
- Structural and Functional Analysis of Angucycline C-6 Ketoreductase LanV Involved in Landomycin Biosynthesis (2013)
- Biochemistry
- Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE (2013)
- Biochemistry
- Identification of Late-Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin (2012)
- ChemBioChem
- Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities (2012)
- Chemistry and Biology
- Flavoprotein Hydroxylase PgaE Catalyzes Two Consecutive Oxygen-Dependent Tailoring Reactions in Angucycline Biosynthesis (2011)
- Biochemistry
- Structure of Collagen Receptor Integrin alpha I-1 Domain Carrying the Activating Mutation E317A (2011)
- Journal of Biological Chemistry
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