Heli Harvala
MD, PhD, EUPHEM Alumni, FRCPath
Virology heli.harvala@utu.fi ORCID-tunniste: https://orcid.org/0000-0001-9154-4190 |
Virology; Clinical Virology; Public Health Virology; Transfusion Virology
Heli Harvala was appointed as a Professor of Virology at the Institute of Biomedicine, University of Turku, Finland in September, 2024.
She graduated in Medicine, obtained a MSc in Organic Chemistry and a PhD in Virology at the University of Turku, Finland, in 2003. Subsequently she completed her Medical Virology training in Edinburgh and became a Fellow of the Royal College of Pathologists in 2015. During that time, she joined the European Public Health Microbiology fellowship programme at the Public Health Agency of Sweden for two years before returning back to the UK. Over the last ten years, she has combined her work as a Consultant Medical Virologist with clinical, transfusion and public health related virology research.
She is a co-founder of the European Non-Polio Enterovirus Network (ENPEN) which evaluates the importance of enterovirus infections and monitors for their emergence together with collaborators from over 30 European countries. During COVID-19 pandemic, she was involved with setting up SARS-CoV-2 testing of convalescent plasma donors in England, and the related international REMAP-CAP trial. She also has wide interests in molecular epidemiology and next generation sequencing, and is involved with investigations into how next generation sequencing could be used to enhance the effectiveness of microbiological donation screening.
She leads the Blood Safety research team within the NIHR funded Blood and Transplant Research Unit at the University of Oxford. This research focuses on transfusion transmitted viral infections aiming to improve our understanding of current risks and preparedness for emerging pathogens. She also recently led the work in identifying occult hepatitis B infections as a blood transfusion risk in England and has done pioneering work to investigate pre-exposure prophylaxis use among syphilis infected blood donors. While these activieis continue, she is currently establishing her research group at the University of Turku.
Prof Harvala is widely published in the field of medical, transfusion and public health virology (over 130 peer reviewed publications, h-index 48). She is an executive committee member of European Society for Clinical Virology and the programme committee member for the European Society for Clinical Microbiology and infectious Diseases. She was recently appointed to the WHO European Region Commission for the Certification of Poliomyelitis Eradication, and previously chaired the WHO R&D Blueprint group on Picornaviruses, the Microbiology Specialist Interest Group for the British Blood Transfusion Society, the Panel of Senior Virology Examiners for the RCPath and the Standing Advisory Committee for Transfusion Transmitted Infections.
She is currently involved in the undergraduate teaching of medical and biomedical students, being responsible for the virology part of that. She has previously been involved in the Undergraduate teaching at the University College of London, University of Edinburgh, the University of Oulu and at the University of Turku. She is also actively engaging with Postgraduate teaching by supervising both PhD and MSc students, and has undertaken PhD Supervisors training at the University of Oxford. Furthermore, she has extensive experience in Clinical Virology specialty training; she has been trained educational supervisor in Clinical Virology since 2016 and trained Royal College of Pathologist Examiner in Clinical Virology since 2017.
Her interest includes developing training further and as an example, she developed a new three-day module in Phylogenetics and Bioinformatics for European Centre for Disease Control (ECDC) Stockholm with the microbiological cases studies in 2016. Subsequently, she led the developing and delivering this for the ECDC summer schools in Stockholm, 2016 and 2017, and for the ECDC EPIET/EUPHEM fellows in Berlin, 2017 and 2018.
- Enterovirus circulation in the WHO European region, 2015–2022: a comparison of data from WHO's three core poliovirus surveillance systems and the European Non-Polio Enterovirus Network (ENPEN) (2025)
- Lancet regional health - Europe
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - HTLV Screening of Blood Donations in England Between 2002 and 2021-Comparison of Screening Strategies (2025)
- Clinical Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial (2025)
- Journal of Infection
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Sustained circulation of enterovirus D68 in Europe in 2023 and the continued evolution of enterovirus D68 B3-lineages associated with distinct amino acid substitutions in VP1 protein (2025)
- Journal of Clinical Virology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Use of polyethylene glycol precipitation and ultracentrifugation to enhance the sensitivity of hepatitis B virus DNA detection (2025)
- Journal of Clinical Virology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A need for confirmatory testing of isolated HBcAb-positive results in screening programs (2024) Fu MX, Simmonds P, Harvala H
- An international review of the characteristics of viral nucleic acid-amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT (2024)
- Vox Sanguinis
- Assessment of twelve echovirus virus-neutralisation assays in Europe: recommendations for harmonisation of non-polio enterovirus sero-surveillance studies (2024)
- Journal of General Virology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Biochemical rationale for transfusion of high titre COVID-19 convalescent plasma (2024)
- Scientific Reports
- Biomarkers of transfusion transmitted occult hepatitis B virus infection: Where are we and what next? (2024)
- Reviews in Medical Virology
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Blood donation screening for hepatitis B virus core antibodies: The importance of confirmatory testing and initial implication for rare blood donor groups (2024)
- Vox Sanguinis
- Castanet: a pipeline for rapid analysis of targeted multi-pathogen genomic data (2024)
- Bioinformatics
- Changes in Phenotypic and Molecular Features of Naïve and Central Memory T Helper Cell Subsets following SARS-CoV-2 Vaccination (2024)
- Vaccines
- Characterising the molecular epidemiology of human parechovirus in young infants in the UK and Canada (2024)
- Journal of Clinical Virology
- Enterovirus A71 and coxsackievirus A6 circulation in England, UK, 2006-2017: A mathematical modelling study using cross-sectional seroprevalence data (2024)
- PLoS Pathogens
- Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study (2024)
- Journal of Infectious Diseases
- Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses (2024)
- Genome Medicine
- International review of blood donation nucleic acid amplification testing (2024)
- Vox Sanguinis
- International review of blood donation screening for anti-HBc and occult hepatitis B virus infection (2024)
- Transfusion
- Parechovirus A Circulation and Testing Capacities in Europe, 2015-2021. (2024)
- Emerging Infectious Diseases