Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID identifier: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- QUANTITATIVE MAPPING OF REGIONAL CEREBRAL BLOOD-FLOW USING IODINE-123-IMP AND SPECT (1994)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - A NEW GRAPHIC PLOT ANALYSIS FOR CEREBRAL BLOOD-FLOW AND PARTITION-COEFFICIENT WITH IODINE-123-IODOAMPHETAMINE AND DYNAMIC SPECT VALIDATION STUDIES USING OXYGEN-15-WATER AND PET (1993)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - MODELING APPROACH TO ELIMINATE THE NEED TO SEPARATE ARTERIAL PLASMA IN O-15 INHALATION POSITRON EMISSION TOMOGRAPHY (1993)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - A CONVENIENT METHOD FOR REGIONAL MONOAMINE OXIDASE-A DETERMINATION BY [C-14] CLORGYLINE AUTORADIOGRAPHY (1992)
- International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
(A1 Refereed original research article in a scientific journal) - A NEW STRATEGY FOR THE ASSESSMENT OF VIABLE MYOCARDIUM AND REGIONAL MYOCARDIAL BLOOD-FLOW USING O-15-WATER AND DYNAMIC POSITRON EMISSION TOMOGRAPHY (1992)
- Circulation
(A1 Refereed original research article in a scientific journal) - PREOPERATIVE PREDICTION OF THE OUTCOME OF CORONARY REVASCULARIZATION USING POSITRON EMISSION TOMOGRAPHY (1992)
- Circulation
(A1 Refereed original research article in a scientific journal) - STIMULATION-ACTIVATION STUDY USING (H2O)-O-15 AND PET - PRINCIPLE AND METHOD (1992)
- Biomedical Research
(A1 Refereed original research article in a scientific journal) - USE OF THE LEFT-VENTRICULAR TIME-ACTIVITY CURVE AS A NONINVASIVE INPUT FUNCTION IN DYNAMIC OXYGEN-15-WATER POSITRON EMISSION TOMOGRAPHY (1992)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - A NEW APPROACH OF WEIGHTED INTEGRATION TECHNIQUE BASED ON ACCUMULATED IMAGES USING DYNAMIC PET AND H-2O-15 (1991)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - MYOCARDIAL TISSUE FRACTION - CORRECTION FOR PARTIAL VOLUME EFFECTS AND MEASURE OF TISSUE VIABILITY (1991)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - NONINVASIVE QUANTIFICATION OF REGIONAL MYOCARDIAL BLOOD-FLOW IN CORONARY-ARTERY DISEASE WITH OXYGEN-15-LABELED CARBON-DIOXIDE INHALATION AND POSITRON EMISSION TOMOGRAPHY (1991)
- Circulation
(A1 Refereed original research article in a scientific journal) - OPTIMAL SCAN TIME OF OXYGEN-15-LABELED WATER INJECTION METHOD FOR MEASUREMENT OF CEREBRAL BLOOD-FLOW (1991)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - OPTIMIZATION OF H-2 O-15-CBF METHOD FOR HIGHER SIGNAL-TO-NOISE RATIO (1991)
- Medical progress through technology
(A1 Refereed original research article in a scientific journal) - A DETERMINATION OF THE REGIONAL BRAIN BLOOD PARTITION-COEFFICIENT OF WATER USING DYNAMIC POSITRON EMISSION TOMOGRAPHY (1989)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - DESIGN AND EVALUATION OF HEADTOME-IV, A WHOLE-BODY POSITRON EMISSION TOMOGRAPH (1989)
- IEEE Transactions on Nuclear Science
(A1 Refereed original research article in a scientific journal) - RADIOSYNTHESIS OF O-15-LABELED HYDROGEN-PEROXIDE (1989)
- Journal of Labelled Compounds and Radiopharmaceuticals
(A1 Refereed original research article in a scientific journal) - 2-F-18 PHENYLALANINE AND 3-F-18 TYROSINE - SYNTHESIS AND PRELIMINARY DATA OF TRACER KINETICS (1988)
- Journal of Labelled Compounds and Radiopharmaceuticals
(A1 Refereed original research article in a scientific journal) - ANATOMICAL ADJUSTMENTS IN BRAIN POSITRON EMISSION TOMOGRAPHY USING CT IMAGES (1988)
- Journal of Computer Assisted Tomography
(A1 Refereed original research article in a scientific journal) - EVALUATION OF REGIONAL DIFFERENCES OF TRACER APPEARANCE TIME IN CEREBRAL TISSUES USING [O-15]WATER AND DYNAMIC POSITRON EMISSION TOMOGRAPHY (1988)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - MEASUREMENT OF ABSOLUTE MYOCARDIAL BLOOD-FLOW WITH (H2O)-O-15 AND DYNAMIC POSITRON-EMISSION TOMOGRAPHY - STRATEGY FOR QUANTIFICATION IN RELATION TO THE PARTIAL-VOLUME EFFECT (1988)
- Circulation
(A1 Refereed original research article in a scientific journal)