A1 Refereed original research article in a scientific journal

OPTIMIZATION OF H-2 O-15-CBF METHOD FOR HIGHER SIGNAL-TO-NOISE RATIO




AuthorsKANNO I, IIDA H, MIURA S

PublisherKLUWER ACADEMIC PUBL

Publication year1991

JournalMedical progress through technology

Journal name in sourceMEDICAL PROGRESS THROUGH TECHNOLOGY

Journal acronymMED PROG TECHNOL

Volume17

Issue3-4

First page 189

Last page192

Number of pages4

ISSN0047-6552


Abstract
We described theoretical principle and data analysis for PET study using intravenous (H2O)-O-15 for measurement of cerebral blood flow (CBF) with emphasis on stimulation study for psychophysiological test. In order to improve signal-to-noise (S/N) ratio in CBF images, we optimized the scan procedures and data analysis. We determined optimal scantime of autoradiographic image to provide minimum S/N ratio as to 90 through 120 sec. Increase of full-width at half-maximum (FWHM) of smoothing filter did reduce the image noise (standard deviation, SD) more rapidly than the partial volume effect. Phantom experiment showed a tendency that a larger FWHM provided a higher statistical t-value.



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