A1 Refereed original research article in a scientific journal
MODELING APPROACH TO ELIMINATE THE NEED TO SEPARATE ARTERIAL PLASMA IN O-15 INHALATION POSITRON EMISSION TOMOGRAPHY
Authors: IIDA H, JONES T, MIURA S
Publisher: SOC NUCLEAR MEDICINE INC
Publication year: 1993
Journal: Journal of Nuclear Medicine
Journal name in source: JOURNAL OF NUCLEAR MEDICINE
Journal acronym: J NUCL MED
Volume: 34
Issue: 8
First page : 1333
Last page: 1340
Number of pages: 8
ISSN: 0161-5505
Abstract
A mathematical model has been developed to predict the arterial metabolite concentration curve using the whole blood radioactivity curve in positron emission tomography (PET) during O-15(2) inhalation. Production of arterial (H2O)-O-15 due to aerobic metabolism in the body was modeled as a single rate constant, which was determined from 200 steady-state values of plasma and whole blood concentrations recorded during continuous inhalation of O-15(2) and (CO2)-O-15. Comparison of this method in eight O-15(2) inhalation studies (four at rest and four during motor stimulation) performed on four subjects resulted in: (1) arterial (H2O)-O-15 curves that were well matched in shape to those measured by the frequent plasma separation and (2) cerebral metabolic rate of oxygen (CMRO2) and cerebral blood f low (CBF) were consistent with those obtained by the frequent plasma separation procedure (maximum difference was 3%). An error sensitivity analysis was also performed and demonstrated that errors expected in this modeling approach caused only negligible errors in CMRO2 and CBF estimates. Thus, the arterial (H2O)-O-15 concentration curve can be accurately predicted using the whole blood time-activity curve; hence, plasma separation can be avoided in O-15(2) inhalation PET.
A mathematical model has been developed to predict the arterial metabolite concentration curve using the whole blood radioactivity curve in positron emission tomography (PET) during O-15(2) inhalation. Production of arterial (H2O)-O-15 due to aerobic metabolism in the body was modeled as a single rate constant, which was determined from 200 steady-state values of plasma and whole blood concentrations recorded during continuous inhalation of O-15(2) and (CO2)-O-15. Comparison of this method in eight O-15(2) inhalation studies (four at rest and four during motor stimulation) performed on four subjects resulted in: (1) arterial (H2O)-O-15 curves that were well matched in shape to those measured by the frequent plasma separation and (2) cerebral metabolic rate of oxygen (CMRO2) and cerebral blood f low (CBF) were consistent with those obtained by the frequent plasma separation procedure (maximum difference was 3%). An error sensitivity analysis was also performed and demonstrated that errors expected in this modeling approach caused only negligible errors in CMRO2 and CBF estimates. Thus, the arterial (H2O)-O-15 concentration curve can be accurately predicted using the whole blood time-activity curve; hence, plasma separation can be avoided in O-15(2) inhalation PET.
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