Tapio Lönnberg
PhD
Turku Bioscience Centre taplon@utu.fi Tykistökatu 6 Turku |
Single-cell genomics, immunology
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
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- Microanatomy of the Human Atherosclerotic Plaque by Single-Cell TranscriptomicsSomatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease (2020)
- Circulation Research
- Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activitiesThe Conjugation of Antibodies for the Simultaneous Detection of Surface Proteins and Transcriptome Analysis at a Single-Cell Level (2020)
- Genome Medicine
- (2020)
- Nature CommunicationsNature Immunology
- 2020Immunometabolism: Methods and protocols Iivari Kleino, Eliisa Kekäläinen, Tapio Lönnberg
- Transcriptome dynamics of CD4(+) T cells during malaria maps gradual transit from effector to memory (2020)
- Early Detection of Peripheral Blood Cell Signature in Children Developing Beta-Cell Autoimmunity at a Young Age (2019)
- DiabetesImmunology and Cell Biology
- Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease2019
- Clinical Epigenetics
- Single-cell immune profiling reveals new insights into colorectal cancerGlobal and targeted approaches to single-cell transcriptome characterization (2019)
- Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils (2019)
- Immunity
- (2018)
- Briefings in Functional Genomics
UTU Research Portal