Tapio Lönnberg
PhD
Single-cell genomics, immunology
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
- Dynamics of T cell and B cell receptor repertoires in response to obesity in a murine model of
atherosclerosis (2024) - European Journal of Immunology
Mikocziova, Ivana; Mikkola, Lea; Palani, Senthil; Roivainen, Anne; Hernández de Sande, Ana; Heinäniemi, Merja; Örd, Tiit; Kaikkonen, Minna U; Lönnberg, Tapio
- Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells (2024) Rytkönen, Kalle T.; Adossa, Nigatu; Zúñiga Norman, Sebastián; Lönnberg, Tapio; Poutanen, Matti; Elo, Laura L.
- Obesity-induced changes in perivascular adipose tissue fibroblasts in a mouse model of atherosclerosis (2024)
- European Journal of Immunology
Mikkola, Lea; Mikocziova, Ivana; Piipponen, Minna; Valkonen, Mira; Fagersund, Jimmy; Palani, Senthil; Roivainen, Anne; Hernández de Sande, Ana; Heinäniemi, Merja; Ruusuvuori, Pekka; Örd, Tiit; Kaikkonen, Minna U; Lönnberg, Tapio
- Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis (2024) Bhattacharya Dipabarna, Theodoropoulos Jason, Nurmi Katariina, Juutilainen Timo, Eklund Kari K., Koivuniemi Riitta, Kelkka Tiina, Mustjoki Satu, Lönnberg Tapio
- Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice (2024) Rinne, Varpu; Gröndahl-Yli-Hannuksela, Kirsi; Fair-Mäkelä, Ruth; Salmi, Marko; Rantakari, Pia; Lönnberg, Tapio; Alinikula, Jukka; Pietikäinen, Annukka; Hytönen, Jukka
- Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures (2023)
- American Journal of Human Genetics
Örd Tiit, Lönnberg Tapio, Nurminen Valtteri, Ravindran Aarthi, Niskanen Henri, Kiema Miika, Õunap Kadri, Maria Maleeha, Moreau Pierre R, Mishra Pashupati P, Palani Senthil, Virta Jenni, Liljenbäck Heidi, Aavik Einari, Roivainen Anne, Ylä-Herttuala Seppo, Laakkonen Johanna P, Lehtimäki Terho, Kaikkonen Minna U
- PIM kinases regulate early human Th17 cell differentiation (2023) Buchacher Tanja, Shetty Ankitha, Koskela Saara A., Smolander Johannes, Kaukonen Riina, Sousa Antonio G. G., Junttila Sini, Laiho Asta, Rundquist Olof, Lonnberg Tapio, Marson Alexander, Rasool Omid, L. Laura, Lahesmaa Riitta
- Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma (2023)
- Journal of Clinical Investigation
Huuhtanen Jani, Kasanen Henna, Peltola Katriina, Lönnberg Tapio, Glumoff Virpi, Brück Oscar, Dufva Olli, Peltonen Karita, Vikkula Johanna, Jokinen Emmi, Ilander Mette, Lee Moon Hee, Mäkelä Siru, Nyakas Marta, Li Bin, Hernberg Micaela, Bono Petri, Lähdesmäki Harri, Kreutzman Anna, Mustjoki Satu
- Transinteractome analysis reveals distinct niche requirements for isotype-based plasma cell subsets in the bone marrow (2023)
- European Journal of Immunology
Bonaud Amélie, Larraufie Pierre, Khamyath Mélanie, Szachnowski Ugo, Flint Shaun M., Brunel-Meunier Nadège, Delhommeau François, Munier Annie, Lönnberg Tapio, Toffano-Nioche Claire, Gautheret Daniel, Balabanian Karl, Espéli Marion
- Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2022) Rytkönen Kalle T, Adossa Nigatu, Mahmoudian Mehrad, Lönnberg Tapio, Poutanen Matti, Elo Laura L
- Evolution and modulation of antigen-specific T cell responses in melanoma patients (2022) Huuhtanen Jani, Chen Liang, Jokinen Emmi, Kasanen Henna, Lönnberg Tapio, Kreutzman Anna, Peltola Katriina, Hernberg Micaela, Wang Chunlin, Yee Cassian, Lähdesmäki Harri, Davis Mark M, Mustjoki Satu
- Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals (2022)
- Journal of Allergy and Clinical Immunology
Vandamme Celine, Rytkönen-Nissinen Marja, Lönnberg Tapio, Randell Jukka, Harvima Rauno J., Kinnunen Tuure, Virtanen Tuomas
- Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia (2022) Huuhtanen Jani, Bhattacharya Dipabarna, Lönnberg Tapio, Kankainen Matti, Kerr Cassandra, Theodoropoulos Jason, Rajala Hanna, Gurnari Carmelo, Kasanen Tiina, Braun Till, Teramo Antonella, Zambello Renato, Herling Marco, Ishida Fumihiro, Kawakami Toru, Salmi Marko, Loughran Thomas, Maciejewski Jaroslaw P., Lähdesmäki Harri, Kelkka Tiina, Mustjoki Satu
- Human adipose tissue-derived stem cell paracrine networks vary according metabolic risk and after TNFα-induced death: an analysis at the single-cell level (2021) Oliva-Olivera Wilfredo, Castellano-Castillo Daniel, von Meyenn Ferdinand, Cardona Fernando, Lönnberg Tapio, Tinahones Francisco J
- Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci (2021) Ord Tiit, Ounap Kadri, Stolze Lindsey K., Aherrahrou Redouane, Nurminen Valtteri, Toropainen Anu, Selvarajan Ilakya, Lönnberg Tapio, Aavik Einari, Ylä-Herttuala Seppo, Civelek Mete, Romanoski Casey E., Kaikkonen Minna U.
- Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021) Virtakoivu Reetta, Rannikko Jenna H, Viitala Miro, Vaura Felix, Takeda Akira, Lönnberg Tapio, Koivunen Jussi, Jaakkola Panu, Pasanen Annika, Shetty Shishir, de Jonge Maja JA, Robbrecht Debbie, Ma Yuk Ting, Skyttä Tanja, Minchom Anna, Jalkanen Sirpa, Karvonen Matti K, Mandelin Jami, Bono Petri, Hollmén Maija
- Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+T Lymphocyte Signature (2020) Tiina Kelkka, Paula Savola, Dipabarna Bhattacharya, Jani Huuhtanen, Tapio Lönnberg, Matti Kankainen, Kirsi Paalanen, Mikko Tyster, Maija Lepistö, Pekka Ellonen, Johannes Smolander, Samuli Eldfors, Bhagwan Yadav, Sofia Khan, Riitta Koivuniemi, Christopher Sjöwall, Laura L. Elo, Harri Lähdesmäki, Yuka Maeda, Hiroyoshi Nishikawa, Marjatta Leirisalo-Repo, Tuulikki Sokka-Isler, Satu Mustjoki
- Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics (2020) Marie A.C. Depuydt, Koen H.M. Prange, Lotte Slenders, Tiit Örd, Danny Elbersen, Arjan Boltjes, Saskia C.A. de Jager, Folkert W. Asselbergs, Gert J. de Borst, Einari Aavik, Tapio Lönnberg, Esther Lutgens, Christopher K. Glass, Hester M. den Ruijter, Minna U. Kaikkonen, Ilze Bot, Bram Slütter, Sander W. van der Laan, Seppo Yla-Herttuala, Michal Mokry, Johan Kuiper, Menno P.J. de Winther, Gerard Pasterkamp
- Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities (2020) Juha Mehtonen, Susanna Teppo, Mari Lahnalampi, Aleksi Kokko, Riina Kaukonen, Laura Oksa, Maria Bouvy-Liivrand, Alena Malyukova, Artturi Mäkinen, Saara Laukkanen, Petri I. Mäkinen, Samuli Rounioja, Pekka Ruusuvuori, Olle Sangfelt, Riikka Lund, Tapio Lönnberg, Olli Lohi, Merja Heinäniemi
- Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease (2020) Daehong Kim, Giljun Park, Jani Huuhtanen, Sofie Lundgren, Rajiv K. Khajuria, Ana M. Hurtado, Cecilia Muñoz-Calleja, Laura Cardeñoso, Valle Gómez-García de Soria, Tzu Hua Chen-Liang, Samuli Eldfors, Pekka Ellonen, Sari Hannula, Matti Kankainen, Oscar Bruck, Anna Kreutzman, Urpu Salmenniemi, Tapio Lönnberg, Andrés Jerez, Maija Itälä-Remes, Mikko Myllymäki, Mikko A. I. Keränen, Satu Mustjoki
