Tapio Lönnberg
PhD
Turku Bioscience Centre taplon@utu.fi +358 29 450 3738 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/orcid.org/0000-0003-4484-5657 |
Areas of expertise
Single-cell genomics, immunology
Single-cell genomics, immunology
Research community or research topic
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Biography
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Research
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
Teaching
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
Publications 
1 of 2
- Dynamics of T cell and B cell receptor repertoires in response to obesity in a murine model of
atherosclerosis (2024)- European Journal of Immunology
(Abstract) - Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells (2024)
- Reproductive Sciences
(A1 Refereed original research article in a scientific journal) - Obesity-induced changes in perivascular adipose tissue fibroblasts in a mouse model of atherosclerosis (2024)
- European Journal of Immunology
(Abstract) - Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis (2024)
- Molecular Medicine
(A1 Refereed original research article in a scientific journal) - Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice (2024)
- Microbes and Infection
(A1 Refereed original research article in a scientific journal) - Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures (2023)
- American Journal of Human Genetics
(A1 Refereed original research article in a scientific journal) - PIM kinases regulate early human Th17 cell differentiation (2023)
- Cell Reports
(A1 Refereed original research article in a scientific journal) - Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma (2023)
- Journal of Clinical Investigation
(A1 Refereed original research article in a scientific journal) - Transinteractome analysis reveals distinct niche requirements for isotype-based plasma cell subsets in the bone marrow (2023)
- European Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2022)
- Reproduction
(A1 Refereed original research article in a scientific journal) - Evolution and modulation of antigen-specific T cell responses in melanoma patients (2022)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals (2022)
- Journal of Allergy and Clinical Immunology
(A1 Refereed original research article in a scientific journal) - Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia (2022)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Human adipose tissue-derived stem cell paracrine networks vary according metabolic risk and after TNFα-induced death: an analysis at the single-cell level (2021)
- Metabolism
(A1 Refereed original research article in a scientific journal) - Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci (2021)
- Circulation Research
(A1 Refereed original research article in a scientific journal) - Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021)
- Clinical Cancer Research
(A1 Refereed original research article in a scientific journal) - Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+T Lymphocyte Signature (2020)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics (2020)
- Circulation Research
(A1 Refereed original research article in a scientific journal) - Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities (2020)
- Genome Medicine
(A1 Refereed original research article in a scientific journal) - Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease (2020)
- Nature Communications
(A1 Refereed original research article in a scientific journal)
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