Tapio Lönnberg
PhD
Turku Bioscience Centre taplon@utu.fi Tykistökatu 6 Turku ORCID identifier: https://orcid.org/orcid.org/0000-0003-4484-5657 |
Areas of expertise
Single-cell genomics, immunology
Single-cell genomics, immunology
Research community or research topic
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Biography
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Research
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
Teaching
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
Publications 
1 of 3
- COMPARISON OF TWO HIGH-RESOLUTION SPATIAL TRANSCRIPTOMICS TECHNOLOGIES TO STUDY SYNOVIAL IMMUNE INFILTRATION IN OSTEOARTHRITIS AND RHEUMATOID ARTHRITISPIM kinases regulate early human Th17 cell differentiation (2025)
- Osteoarthritis and Cartilage
(Abstract) - Identifying immune mediators of osteoarthritis pain (2025) Metso, Sara; Lönnberg, Tapio; Mikkola, Lea
(Poster) - Integrin β1 activity controls colony morphology during human pluripotent stem cell state transitionsCell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2025)
- Stem Cell ReportsReproduction
(A1 Refereed original research article in a scientific journal) - MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution (2025)
- Genome Medicine
(A1 Refereed original research article in a scientific journal) - Dynamics of T cell and B cell receptor repertoires in response to obesity in a murine model of
atherosclerosisSingle-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals (2024)- European Journal of ImmunologyJournal of Allergy and Clinical Immunology
(Abstract) - Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells (2024)
- Reproductive Sciences
(A1 Refereed original research article in a scientific journal) - High-fidelity spatial transcriptomics reveals the distribution, interactions and relations of several inflammatory cell types in murine atherosclerotic plaques (2024)
- Atherosclerosis
(Abstract) - Obesity-induced changes in perivascular adipose tissue fibroblasts in a mouse model of atherosclerosis (2024)
- European Journal of Immunology
(Abstract) - Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis (2024)
- Molecular Medicine
(A1 Refereed original research article in a scientific journal) - Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice (2024)
- Microbes and Infection
(A1 Refereed original research article in a scientific journal) - Disease-associated cell states in atherosclerosis defined by spatial transcriptomics (2023)
- Atherosclerosis
(Abstract) - Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures (2023)
- American Journal of Human Genetics
(A1 Refereed original research article in a scientific journal) - (2023)
- Cell Reports
(A1 Refereed original research article in a scientific journal) - Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma (2023)
- Journal of Clinical Investigation
(A1 Refereed original research article in a scientific journal) - Transinteractome analysis reveals distinct niche requirements for isotype-based plasma cell subsets in the bone marrow (2023)
- European Journal of Immunology
(A1 Refereed original research article in a scientific journal) - 2022
(A1 Refereed original research article in a scientific journal) - Evolution and modulation of antigen-specific T cell responses in melanoma patients (2022)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - (2022)
(A1 Refereed original research article in a scientific journal) - Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia (2022)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Human adipose tissue-derived stem cell paracrine networks vary according metabolic risk and after TNFα-induced death: an analysis at the single-cell level (2021)
- Metabolism
(A1 Refereed original research article in a scientific journal)
UTU Research Portal