Tapio Lönnberg
PhD
Turku Bioscience Centre taplon@utu.fi Tykistökatu 6 Turku |
Single-cell genomics, immunology
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
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- Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals (2022)
- Journal of Allergy and Clinical Immunology
- Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia (2022)
- Nature Communications
- Human adipose tissue-derived stem cell paracrine networks vary according metabolic risk and after TNFα-induced death: an analysis at the single-cell level (2021)
- Metabolism
- Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci (2021)
- Circulation Research
- Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021)
- Clinical Cancer Research
- Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+T Lymphocyte Signature (2020)
- Frontiers in immunology
- Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics (2020)
- Circulation Research
- Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities (2020)
- Genome Medicine
- Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease (2020)
- Nature Communications
- The Conjugation of Antibodies for the Simultaneous Detection of Surface Proteins and Transcriptome Analysis at a Single-Cell Level (2020) Immunometabolism: Methods and protocols Iivari Kleino, Eliisa Kekäläinen, Tapio Lönnberg
- Transcriptome dynamics of CD4(+) T cells during malaria maps gradual transit from effector to memory (2020)
- Nature Immunology
- Early Detection of Peripheral Blood Cell Signature in Children Developing Beta-Cell Autoimmunity at a Young Age (2019)
- Diabetes
- Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease (2019)
- Clinical Epigenetics
- Single-cell immune profiling reveals new insights into colorectal cancer (2019)
- Immunology and Cell Biology
- Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils (2019)
- Immunity
- Global and targeted approaches to single-cell transcriptome characterization (2018)
- Briefings in Functional Genomics
- Single-cell RNA-sequencing resolves self-antigen expression during mTEC development (2018)
- Scientific Reports
- A practical guide to single-cell RNA- sequencing for biomedical research and clinical applications (2017)
- Genome Medicine
- Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFH fate bifurcation in malaria (2017)
- Science Immunology
- Cutting-edge single-cell genomics and modelling in immunology (2016)
- Immunology and Cell Biology
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