Tapio Lönnberg
PhD
Turku Bioscience Centre taplon@utu.fi Tykistökatu 6 Turku ORCID identifier: https://orcid.org/orcid.org/0000-0003-4484-5657 |
Areas of expertise
Single-cell genomics, immunology
Single-cell genomics, immunology
Research community or research topic
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship
Biography
- Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
- Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
- Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
- 2021- Group Leader at InFLAMES Flagship
- Secretary of the Finnish Society for Immunology
Research
Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.
Teaching
- Modern biotechnologies and bioinformatics
- Medical biotechnology
- Advanced Immunology
Publications 
3 of 6
- Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma (2023)
- Journal of Clinical Investigation
(A1 Refereed original research article in a scientific journal) - Transinteractome analysis reveals distinct niche requirements for isotype-based plasma cell subsets in the bone marrow (2023)
- European Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2022)
- Reproduction
(A1 Refereed original research article in a scientific journal) - Evolution and modulation of antigen-specific T cell responses in melanoma patients (2022)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals (2022)
- Journal of Allergy and Clinical Immunology
(A1 Refereed original research article in a scientific journal) - Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia (2022)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Human adipose tissue-derived stem cell paracrine networks vary according metabolic risk and after TNFα-induced death: an analysis at the single-cell level (2021)
- Metabolism
(A1 Refereed original research article in a scientific journal) - Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci (2021)
- Circulation Research
(A1 Refereed original research article in a scientific journal) - Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021)
- Clinical Cancer Research
(A1 Refereed original research article in a scientific journal) - Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+T Lymphocyte Signature (2020)
- Frontiers in immunology
(A1 Refereed original research article in a scientific journal)
UTU Research Portal