MS Olena Parilova - UTU Research Portal

Olena Parilova
MS

- ,
Biochemistry (Department of Life Technologies)
- Doctoral Researcher,
Department of Life Technologies (Faculty of Technology)

olena.parilova@utu.fi

: B311 (3 floor)

RNA polymerase I; in vitro transcription; protein purification; structural biology

I focus on the mechanism of transcription initiation by RNA polymerase I (Pol1). I study in vitro reconstituted Pol1 system from Saccharomyces cerevisiae as a model and elucidate its function using single molecule biophysical methods capable of real-time monitoring of proteins.

Real-Time Single-Molecule Studies of RNA Polymerase–Promoter Open Complex Formation Reveal Substantial Heterogeneity Along the Promoter-Opening Pathway (2022)
- Journal of Molecular Biology
Malinen Anssi M., Bakermans Jacob, Aalto-Setälä Emil, Blessing Martin, Bauer David L.V., Parilova Olena, Belogurov Georgiy A., Dulin David, Kapanidis Achillefs N.
Archaic and alternative chaperones preserve pilin folding energy by providing incomplete structural information (2018)
- Journal of Biological Chemistry
Pakharukova N, McKenna S, Tuittila M, Paavilainen S, Malmi H, Xu Y, Parilova O, Matthews S, Zavialov AV
Structural basis for Acinetobacter baumannii biofilm formation (2018)
- Proceedings of the National Academy of Sciences of the United States of America
Natalia Pakharukova, Minna Tuittila, Sari Paavilainen, Henri Malmi, Olena Parilova, Susann Teneberg, Stefan D. Knight, Anton V. Zavialov