Pieta Mattila
InFLAMES Group Leader, Adjunct Professor
MediCity Research Laboratories, Turku Bioscience Centre pieta.mattila@utu.fi +358 29 450 4431 Tykistökatu 6 Turku : https://orcid.org/0000-0003-2805-0686 |
Immunology
B cells
Antigen receptor signaling
Cell biology
Actin cytoskeleton
Plasma membrane
Advanced microscopy
Education:
MSc in Biochemistry 2002 (University of Oulu, Finland)
PhD in Genetics 2008 (University of Helsinki)
Postdoc: Cancer Research UK, London Research Institute 2008-2012
Adjunct Professor: 2014
Group leader in the InFLAMES research flagship 2022-> (University of Turku)
Academy of Finland Research Fellow 2016-2022 (University of Turku)
B lymphocytes are key cells in mounting the adaptive immune response by differentiating into antibody secreting plasma cells. Our group is interested in the molecular mechanisms of B lymphocyte activation, with emphasis on receptor activation and its immediate cell biological responses, culminating at the reorganization of the actin cytoskeleton, plasma membrane and intracellular vesicle traffic. In our research, we take advantage of both in vivo models and various advanced imaging techniques, including super-resolution microscopy, as well as modern proteomic approaches such as APEX2 proximity biotinylation.
More information about our projects, including our publications, can be found at: http://mattilalab.utu.fi.
I am lecturing on various Master’s and PhD level courses on topics including the adaptive immune system, cell signaling, cytoskeleton, and microscopy. I have been involved in designing new courses targeted for PhD students and postdocs. I have done University Pedagogics 1 course to develop my pedagogic skills. At every day level, I am supervising
doctoral students, postdocs, as well as guide Master’s thesis projects.
- Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling (2016)
- EMBO Journal
- IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal Responses (2015)
- Scandinavian Journal of Immunology
- MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation. (2015) Saarikangas J, Kourdougli N, Senju Y, Chazal G, Segerstråle M, Minkeviciene R, Kuurne J, Mattila PK, Garrett L, Hölter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, von Ossowski L, Taira T, Lappalainen P, Rivera C, Hotulainen P.
- Molecular Control of B Cell Activation and Immunological Synapse Formation (2015)
- Traffic
- The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling (2013)
- Immunity
- Contractility-dependent actin dynamics in cardiomyocyte sarcomeres (2009)
- Journal of Cell Science
- Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins (2009)
- Current Biology
- ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension (2008)
- Journal of Cell Science
- Filopodia: molecular architecture and cellular functions (2008)
- Nature Reviews Molecular Cell Biology
- Mechanism and biological role of profilin-Srv2/CAP interaction (2007)
- Journal of Cell Science
- Missing-in-metastasis and IRSp53 deform PI(4,5)P-2-rich membranes by an inverse BAR domain-like mechanism (2007)
- Journal of Cell Biology
- A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein (2004)
- Molecular Biology of the Cell
- Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells (2004)
- Molecular Biology of the Cell
- Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain (2003)
- Journal of Biological Chemistry
- The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics (2002)
- Molecular Biology of the Cell
- WH2 domain: a small, versatile adapter for actin monomers (2002)
- FEBS Letters
- Twinfilin is required for actin-dependent developmental processes in Drosophila (2001)
- Journal of Cell Biology