Pieta Mattila
InFLAMES Group Leader, Adjunct Professor
MediCity Research Laboratories, Turku Bioscience Centre pieta.mattila@utu.fi +358 29 450 4431 Tykistökatu 6 Turku : https://orcid.org/0000-0003-2805-0686 |
Immunology
B cells
Antigen receptor signaling
Cell biology
Actin cytoskeleton
Plasma membrane
Advanced microscopy
Education:
MSc in Biochemistry 2002 (University of Oulu, Finland)
PhD in Genetics 2008 (University of Helsinki)
Postdoc: Cancer Research UK, London Research Institute 2008-2012
Adjunct Professor: 2014
Group leader in the InFLAMES research flagship 2022-> (University of Turku)
Academy of Finland Research Fellow 2016-2022 (University of Turku)
B lymphocytes are key cells in mounting the adaptive immune response by differentiating into antibody secreting plasma cells. Our group is interested in the molecular mechanisms of B lymphocyte activation, with emphasis on receptor activation and its immediate cell biological responses, culminating at the reorganization of the actin cytoskeleton, plasma membrane and intracellular vesicle traffic. In our research, we take advantage of both in vivo models and various advanced imaging techniques, including super-resolution microscopy, as well as modern proteomic approaches such as APEX2 proximity biotinylation.
More information about our projects, including our publications, can be found at: http://mattilalab.utu.fi.
I am lecturing on various Master’s and PhD level courses on topics including the adaptive immune system, cell signaling, cytoskeleton, and microscopy. I have been involved in designing new courses targeted for PhD students and postdocs. I have done University Pedagogics 1 course to develop my pedagogic skills. At every day level, I am supervising
doctoral students, postdocs, as well as guide Master’s thesis projects.
- Enhanced antibody responses in CD19-Cre mice (2025)
- Scientific Reports
- High-Resolution Imaging of Intracellular Trafficking of B Cell Receptor Using Specific Hybridization Internalization Probe (SHIP) (2025) B-Cell Receptor Signaling - Methods and Protocols Hernández-Pérez, Sara, Mattila, Pieta K.
- Endolysosomal vesicles at the center of B cell activation (2024)
- Journal of Cell Biology
- B cell receptor-induced protein dynamics and the emerging role of SUMOylation revealed by proximity proteomics (2023)
- Journal of Cell Science
- CD73 regulates zoledronate-induced lymphocyte infiltration in triple-negative breast cancer tumors and lung metastases (2023)
- Frontiers in Immunology
- Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration (2023)
- Small Methods
- Isolation of the B Cell Immune Synapse for Proteomic Analysis (2023)
- Methods in Molecular Biology
- The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery (2023)
- Cells
- A specific hybridisation internalisation probe (SHIP) enables precise live-cell and super-resolution imaging of internalized cargo (2022)
- Scientific Reports
- AutoCoEv-A High-Throughput In Silico Pipeline for Predicting Inter-Protein Coevolution (2022)
- International Journal of Molecular Sciences
- The SNARE protein Vti1b is recruited to the sites of BCR activation but is redundant for antigen internalisation, processing and presentation (2022)
- Frontiers in cell and developmental biology
- Analysis of intracellular vesicles in B lymphocytes: antigen traffic in the spotlight (2021) Confocal Microscopy: Methods and Protocols Hernández-Pérez Sara, Runsala Marika, Šuštar Vid, Mattila Pieta K.
- Democratising deep learning for microscopy with ZeroCostDL4Mic (2021)
- Nature Communications
- B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments (2020)
- Journal of Cell Science
- Missing-in-Metastasis/Metastasis Suppressor 1 Regulates B Cell Receptor Signaling, B Cell Metabolic Potential, and T Cell-Independent Immune Responses (2020)
- Frontiers in Immunology
- STING couples with PI3K to regulate actin reorganization during BCR activation (2020)
- Science Advances
- Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control (2019)
- Scientific Reports
- Visualization and quantitative analysis of the actin cytoskeleton upon B cell activation (2018) B Cell Receptor Signaling. Methods in Molecular Biology Vid Šuštar, Marika Vainio, Pieta K. Mattila
- The Small Rho GTPase TC10 Modulates B Cell Immune Responses (2017)
- Journal of Immunology
- Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling (2016)
- Journal of Cell Biology