Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins



: Saarikangas J, Zhao HX, Pykalainen A, Laurinmaki P, Mattila PK, Kinnunen PKJ, Butcher SJ, Lappalainen P

Publisher: CELL PRESS

: 2009

: Current Biology

: CURRENT BIOLOGY

: CURR BIOL

: 19

: 2

: 95

: 107

: 13

: 0960-9822

DOI: https://doi.org/10.1016/j.cub.2008.12.029


Conclusions: These data define I-BAR domain as a functional member of the BAR domain superfamily and unravel the mechanisms by which I-BAR domains deform membranes to induce filopodia in cells. Furthermore, our work reveals unexpected divergence in the mechanisms by which evolutionarily distinct groups of I-BAR domains interact with PI(4,5)P(2)-rich membranes.

Last updated on 2024-26-11 at 20:35